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- W3204275 abstract "To evaluate the effectiveness of n -telopeptides and E 2 in monitoring bone turnover during GnRH agonist- (GnRH-a) or danazol-induced hypoestrogenism. Comparative, nonrandomized prospective study. Institute for the Study and Treatment of Endometriosis Premenopausal women undergoing ovarian suppression with GnRH-a (n = 16) or danazol (n = 9). Serum and urine samples were collected and bone mineral density was measured before, during, and after treatment n -telopeptide excretion, serum E 2 , and bone mineral density at L1 to L4 and femoral neck. During treatment in the GnRH-a group, mean E 2 levels were 53% below and n -telopeptides were 38% above the mean baseline. At 1 month post-treatment, L1 to L4 bone mineral density decreased by 3.85%. In the danazol group, E 2 , n -telopeptides and L1 to L4 bone mineral density changed nonsignificantly in the opposite direction with the mean 1.25% increase in L1 to L4 at 1 month post-treatment. In combined groups, L1 to L4 bone mineral density better correlated with other measures than femoral neck bone mineral density. n -telopeptide excretion was more predictive of L1 to L4 change, with correlation the highest between n -telopeptides at month 4 and bone mineral density at month 1 afterward, while E 2 appeared more predictive of the less reliable femoral neck bone mineral density. Individual exceptions to the model of an E 2 threshold for bone loss were observed. Also noted were high correlation between on-therapy levels of E 2 and n -telopeptides, as well as the presence of a 1-month time lag between E 2 and n -telopeptide changes. Bone density decreases during GnRH-a and may slightly increase during danazol treatment. However, E 2 threshold for bone loss varies individually. n -telopeptides predict changes in bone mineral density at L1 to L4 better than E 2 ." @default.
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- W3204275 date "1996-12-01" @default.
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- W3204275 title "Excretion of urinary n-telopeptides reflects changes in bone turnover during ovarian suppression and indicates individually variable estradiol threshold for bone loss" @default.
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- W3204275 doi "https://doi.org/10.1016/s0015-0282(16)58685-3" @default.
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