Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204276044> ?p ?o ?g. }
- W3204276044 endingPage "15650" @default.
- W3204276044 startingPage "15639" @default.
- W3204276044 abstract "Hepatocellular carcinoma (HCC) is rising steadily in incidence, and more effective methods are needed for early detection and image-guided surgery. Glypican-3 (GPC3) is a cell surface biomarker that is overexpressed in early-stage cancer but not in cirrhosis. An IRDye800-labeled 12-mer amino acid sequence was identified, and specific binding to GPC3 was validated in vitro and in orthotopically implanted HCC tumors in vivo. Over 4-fold greater binding affinity and 2-fold faster kinetics were measured by comparison with previous GPC3 peptides. Photoacoustic images showed peak tumor uptake at 1.5 h post-injection and clearance within ∼24 h. Laparoscopic and whole-body fluorescence images showed strong intensity from tumor versus adjacent liver with about a 2-fold increase. Immunofluorescence staining of human liver specimens demonstrated specific binding to HCC versus cirrhosis with 79% sensitivity and 79% specificity, and normal liver with 81% sensitivity and 84% specificity. The near-infrared peptide is promising for early HCC detection in clinical trials." @default.
- W3204276044 created "2021-10-11" @default.
- W3204276044 creator A5003962263 @default.
- W3204276044 creator A5007402362 @default.
- W3204276044 creator A5013603541 @default.
- W3204276044 creator A5018580304 @default.
- W3204276044 creator A5034676466 @default.
- W3204276044 creator A5067288072 @default.
- W3204276044 creator A5075981406 @default.
- W3204276044 creator A5078504833 @default.
- W3204276044 creator A5079759086 @default.
- W3204276044 creator A5084793403 @default.
- W3204276044 creator A5086113297 @default.
- W3204276044 date "2021-09-30" @default.
- W3204276044 modified "2023-09-23" @default.
- W3204276044 title "Multi-Modal Imaging Probe for Glypican-3 Overexpressed in Orthotopic Hepatocellular Carcinoma" @default.
- W3204276044 cites W1529818809 @default.
- W3204276044 cites W1534575982 @default.
- W3204276044 cites W1856275929 @default.
- W3204276044 cites W1948423467 @default.
- W3204276044 cites W1960912034 @default.
- W3204276044 cites W1971837077 @default.
- W3204276044 cites W1973027060 @default.
- W3204276044 cites W1973276320 @default.
- W3204276044 cites W1976801200 @default.
- W3204276044 cites W1992462510 @default.
- W3204276044 cites W1995040137 @default.
- W3204276044 cites W1999877835 @default.
- W3204276044 cites W2000260992 @default.
- W3204276044 cites W2002516695 @default.
- W3204276044 cites W2004818616 @default.
- W3204276044 cites W2011983613 @default.
- W3204276044 cites W2017078824 @default.
- W3204276044 cites W2017861663 @default.
- W3204276044 cites W2020213757 @default.
- W3204276044 cites W2028156849 @default.
- W3204276044 cites W2030678976 @default.
- W3204276044 cites W2037248548 @default.
- W3204276044 cites W2037455416 @default.
- W3204276044 cites W2042076423 @default.
- W3204276044 cites W2048313558 @default.
- W3204276044 cites W2061374201 @default.
- W3204276044 cites W2065589690 @default.
- W3204276044 cites W2072183900 @default.
- W3204276044 cites W2073378251 @default.
- W3204276044 cites W2096866380 @default.
- W3204276044 cites W2106285087 @default.
- W3204276044 cites W2108900994 @default.
- W3204276044 cites W2110369939 @default.
- W3204276044 cites W2123915668 @default.
- W3204276044 cites W2125236475 @default.
- W3204276044 cites W2125900063 @default.
- W3204276044 cites W2134589440 @default.
- W3204276044 cites W2152166430 @default.
- W3204276044 cites W2167798860 @default.
- W3204276044 cites W2270871986 @default.
- W3204276044 cites W2280132335 @default.
- W3204276044 cites W2506318659 @default.
- W3204276044 cites W2525980773 @default.
- W3204276044 cites W2554165867 @default.
- W3204276044 cites W2594790327 @default.
- W3204276044 cites W2624710378 @default.
- W3204276044 cites W2766649429 @default.
- W3204276044 cites W2787358630 @default.
- W3204276044 cites W2792923735 @default.
- W3204276044 cites W2886229412 @default.
- W3204276044 cites W2889270422 @default.
- W3204276044 cites W2889646458 @default.
- W3204276044 cites W2897031692 @default.
- W3204276044 cites W2904231344 @default.
- W3204276044 cites W2912930263 @default.
- W3204276044 cites W2949289995 @default.
- W3204276044 cites W2991085943 @default.
- W3204276044 cites W2999385244 @default.
- W3204276044 cites W2999417355 @default.
- W3204276044 cites W3002132094 @default.
- W3204276044 cites W3080818483 @default.
- W3204276044 cites W4206384507 @default.
- W3204276044 cites W4210271223 @default.
- W3204276044 cites W4297745080 @default.
- W3204276044 doi "https://doi.org/10.1021/acs.jmedchem.1c00697" @default.
- W3204276044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34590489" @default.
- W3204276044 hasPublicationYear "2021" @default.
- W3204276044 type Work @default.
- W3204276044 sameAs 3204276044 @default.
- W3204276044 citedByCount "2" @default.
- W3204276044 countsByYear W32042760442022 @default.
- W3204276044 crossrefType "journal-article" @default.
- W3204276044 hasAuthorship W3204276044A5003962263 @default.
- W3204276044 hasAuthorship W3204276044A5007402362 @default.
- W3204276044 hasAuthorship W3204276044A5013603541 @default.
- W3204276044 hasAuthorship W3204276044A5018580304 @default.
- W3204276044 hasAuthorship W3204276044A5034676466 @default.
- W3204276044 hasAuthorship W3204276044A5067288072 @default.
- W3204276044 hasAuthorship W3204276044A5075981406 @default.
- W3204276044 hasAuthorship W3204276044A5078504833 @default.
- W3204276044 hasAuthorship W3204276044A5079759086 @default.
- W3204276044 hasAuthorship W3204276044A5084793403 @default.