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• W3204276244 abstract "Abstract Cancer is a leading cause of death worldwide. The chemotherapy is one of a major treatment for cancer. However, resistance to chemotherapeutic agents is still a crucial problem in cancer therapies. Majority drug resistance results from the accumulation of mutation of genes in the minority-resistant cells. The mechanism underlying the emergence and the development of cancer resistance from minority-resistant cells has not been fully elucidated. Here, we revealed that minority taxol-resistant cancer cells (MRCs) with enhanced mechanical force can transmit the high force to surrounding sensitive cells through force transducer merlin, and thus enhancing the contraction and adhesion strength of tumor cells (termed as mechanoassimilation), which eventually accelerates the development of drug resistance and tumor progression in vivo. In addition, disturbance and reduction of mechanoassimilation in tumor leads them sensitive to taxol again in vitro and in vivo, which also provide a preliminary indication of MRC contribution in drug-resistance and malignancy development through mechanoassimilation, and offer a new opportunity for cancer therapy by targeting the tumor mechanics." @default.
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• W3204276244 date "2021-09-30" @default.
• W3204276244 modified "2023-10-18" @default.
• W3204276244 title "The mechanical force of minority cells modulates the tumor taxol-resistance and progression" @default.
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• W3204276244 doi "https://doi.org/10.21203/rs.3.rs-948406/v1" @default.
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