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- W3204278090 abstract "3272 The CDKN2a locus on human chromosome 9 at 9p21 encodes two tumor suppressor proteins: CDKN2a protein (p16, Ink4a), a cell cycle inhibitor in the RB pathway, and p14ARF (ARF), which is linked to both the p53 and RB pathways. This locus is of considerable evolutionary interest for several reasons. Adjacent to CDKN2a is CDKN2b; these proteins are likely the result of a duplication event from an ancestral gene, although only CDKN2a appears to be important in carcinogenesis. The CDKN2a (p16) and ARF proteins share exon 2 in different reading frames, but have distinct first exons. It appears that ARF exon 1β was inserted into this locus, but it is uncertain when in evolutionary history this occurred. It also has been suggested that a gene conversion event has occurred in exon 2 of the human gene. We have updated the CDKN2a phylogenetic tree based on published sequences and data from ongoing genome projects, and we performed computational studies of intragenic evolution. Our data suggest that no gene conversion event has occurred in CDKN2a evolutionary history. We cannot determine whether exon 1β inserted into the region before or after the CDKN2a/b duplication. Additionally, the amount of evolutionary variation among the existing set of p16 sequences is lower than a similar set of p53 sequences. The observed evolutionary variation is not sufficient to state with statistical significance whether a given amino acid within p16 is “absolutely conserved”. Further phylogenetic comparisons of CDKN2a cDNA and genomic DNA are ongoing to reconstruct the evolutionary history of this important growth control locus." @default.
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- W3204278090 date "2004-04-01" @default.
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- W3204278090 title "Phylogeny of the CDKN2a/p14ARF locus." @default.
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