FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204285110> ?p ?o ?g. }

• W3204285110 endingPage "1433" @default.
• W3204285110 startingPage "1419" @default.
• W3204285110 abstract "Peroxisomes metabolize a specific subset of fatty acids, which include dicarboxylic fatty acids (DCAs) generated by ω-oxidation. Data obtained in vitro suggest that the peroxisomal transporter ABCD3 (also known as PMP70) mediates the transport of DCAs into the peroxisome, but in vivo evidence to support this role is lacking. In this work, we studied an Abcd3 KO mouse model generated by CRISPR-Cas9 technology using targeted and untargeted metabolomics, histology, immunoblotting, and stable isotope tracing technology. We show that ABCD3 functions in hepatic DCA metabolism and uncover a novel role for this peroxisomal transporter in lipid homeostasis. The Abcd3 KO mouse presents with increased hepatic long-chain DCAs, increased urine medium-chain DCAs, lipodystrophy, enhanced hepatic cholesterol synthesis and decreased hepatic de novo lipogenesis. Moreover, our study suggests that DCAs are metabolized by mitochondrial fatty acid β-oxidation when ABCD3 is not functional, reflecting the importance of the metabolic compartmentalization and communication between peroxisomes and mitochondria. In summary, this study provides data on the role of the peroxisomal transporter ABCD3 in hepatic lipid homeostasis and DCA metabolism, and the consequences of peroxisomal dysfunction for the liver." @default.
• W3204285110 created "2021-10-11" @default.
• W3204285110 creator A5003096235 @default.
• W3204285110 creator A5027726446 @default.
• W3204285110 creator A5036096239 @default.
• W3204285110 creator A5040695004 @default.
• W3204285110 creator A5057489970 @default.
• W3204285110 creator A5059954218 @default.
• W3204285110 creator A5076560982 @default.
• W3204285110 creator A5082344494 @default.
• W3204285110 date "2021-10-02" @default.
• W3204285110 modified "2023-10-17" @default.
• W3204285110 title "The peroxisomal transporter <scp>ABCD3</scp> plays a major role in hepatic dicarboxylic fatty acid metabolism and lipid homeostasis" @default.
• W3204285110 cites W1495117278 @default.
• W3204285110 cites W1509781249 @default.
• W3204285110 cites W1547646031 @default.
• W3204285110 cites W1563438791 @default.
• W3204285110 cites W1606277396 @default.
• W3204285110 cites W1846402700 @default.
• W3204285110 cites W1918619761 @default.
• W3204285110 cites W1922810628 @default.
• W3204285110 cites W1934014088 @default.
• W3204285110 cites W1972027498 @default.
• W3204285110 cites W1975534757 @default.
• W3204285110 cites W1985051677 @default.
• W3204285110 cites W1988202402 @default.
• W3204285110 cites W1989988844 @default.
• W3204285110 cites W1991911813 @default.
• W3204285110 cites W1995392322 @default.
• W3204285110 cites W2007248090 @default.
• W3204285110 cites W2020017815 @default.
• W3204285110 cites W2023227985 @default.
• W3204285110 cites W2025701648 @default.
• W3204285110 cites W2027243554 @default.
• W3204285110 cites W2040365013 @default.
• W3204285110 cites W2046335999 @default.
• W3204285110 cites W2047710690 @default.
• W3204285110 cites W2065732746 @default.
• W3204285110 cites W2072066566 @default.
• W3204285110 cites W2083502866 @default.
• W3204285110 cites W2088794057 @default.
• W3204285110 cites W2089553960 @default.
• W3204285110 cites W2090124334 @default.
• W3204285110 cites W2094584320 @default.
• W3204285110 cites W2095032878 @default.
• W3204285110 cites W2096369714 @default.
• W3204285110 cites W2114535339 @default.
• W3204285110 cites W2118768829 @default.
• W3204285110 cites W2123116985 @default.
• W3204285110 cites W2133128364 @default.
• W3204285110 cites W2134362277 @default.
• W3204285110 cites W2141470945 @default.
• W3204285110 cites W2143930443 @default.
• W3204285110 cites W2149600437 @default.
• W3204285110 cites W2152977496 @default.
• W3204285110 cites W2155414337 @default.
• W3204285110 cites W2159461168 @default.
• W3204285110 cites W2165118279 @default.
• W3204285110 cites W2166868058 @default.
• W3204285110 cites W2167279371 @default.
• W3204285110 cites W2189202583 @default.
• W3204285110 cites W2411587935 @default.
• W3204285110 cites W2518901523 @default.
• W3204285110 cites W2791808110 @default.
• W3204285110 cites W2803664483 @default.
• W3204285110 cites W2904375134 @default.
• W3204285110 cites W2994800664 @default.
• W3204285110 cites W3118674668 @default.
• W3204285110 cites W3167216302 @default.
• W3204285110 cites W3177004565 @default.
• W3204285110 doi "https://doi.org/10.1002/jimd.12440" @default.
• W3204285110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8578467" @default.
• W3204285110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34564857" @default.
• W3204285110 hasPublicationYear "2021" @default.
• W3204285110 type Work @default.
• W3204285110 sameAs 3204285110 @default.
• W3204285110 citedByCount "8" @default.
• W3204285110 countsByYear W32042851102022 @default.
• W3204285110 countsByYear W32042851102023 @default.
• W3204285110 crossrefType "journal-article" @default.
• W3204285110 hasAuthorship W3204285110A5003096235 @default.
• W3204285110 hasAuthorship W3204285110A5027726446 @default.
• W3204285110 hasAuthorship W3204285110A5036096239 @default.
• W3204285110 hasAuthorship W3204285110A5040695004 @default.
• W3204285110 hasAuthorship W3204285110A5057489970 @default.
• W3204285110 hasAuthorship W3204285110A5059954218 @default.
• W3204285110 hasAuthorship W3204285110A5076560982 @default.
• W3204285110 hasAuthorship W3204285110A5082344494 @default.
• W3204285110 hasBestOaLocation W32042851102 @default.
• W3204285110 hasConcept C104317684 @default.
• W3204285110 hasConcept C127078168 @default.
• W3204285110 hasConcept C141359234 @default.
• W3204285110 hasConcept C19038510 @default.
• W3204285110 hasConcept C2777171753 @default.
• W3204285110 hasConcept C4733338 @default.
• W3204285110 hasConcept C543025807 @default.
• W3204285110 hasConcept C55493867 @default.
• W3204285110 hasConcept C82714985 @default.

• next