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- W3204285229 endingPage "2083" @default.
- W3204285229 startingPage "2083" @default.
- W3204285229 abstract "The hepatitis B core-related antigen (HBcrAg) is an unprecedented novel HBV biomarker that plays an essential role in reflecting covalently closed circular DNA (cccDNA) in chronic hepatitis B (CHB) because its levels correlate with intrahepatic cccDNA and serum HBV DNA. In this review, we describe the clinical application of serum HBcrAg in CHB patients, with a particular focus on new therapies targeting intrahepatic HBV replication. (1) HBcrAg can be detected in clinical cases where serum HBV DNA is undetectable during anti-HBV therapy. (2) A highly sensitive HBcrAg assay (iTACT-HBcrAg) may be useful for monitoring HBV reactivation, as an alternative to HBV DNA. (3) Decreased HBcrAg levels have been significantly associated with promising outcomes in CHB patients, reducing the risk of progression or recurrence of hepatocellular carcinoma. Additionally, we focus on and discuss several drugs in development that target HBV replication, and monitoring HBcrAg may be useful for determining the therapeutic efficacies of such novel drugs. In conclusion, HBcrAg, especially when measured by the recently developed iTACT-HBcrAg assay, may be the most appropriate surrogate marker, over other HBV biomarkers, to predict disease progression and treatment response in CHB patients." @default.
- W3204285229 created "2021-10-11" @default.
- W3204285229 creator A5009887722 @default.
- W3204285229 creator A5027469624 @default.
- W3204285229 creator A5080762743 @default.
- W3204285229 date "2021-10-02" @default.
- W3204285229 modified "2023-10-16" @default.
- W3204285229 title "Hepatitis B Core-Related Antigen and New Therapies for Hepatitis B" @default.
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