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- W3204285940 endingPage "1232" @default.
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- W3204285940 abstract "Careful selection of photocaging approaches is critical to achieve fast and well synchronized reaction initiation and perform successful time-resolved structural biology experiments. This review summarizes the best characterized and most relevant photocaging groups previously described in the literature. It also provides a walkthrough of the essential factors to consider in designing a suitable photocaged molecule to address specific biological questions, focusing on photocaging groups with well characterized spectroscopic properties. The relationships between decay rates (k in s-1), quantum yields (ϕ) and molar extinction coefficients (ϵmax in M-1 cm-1) are highlighted for different groups. The effects of the nature of the photocaged group on these properties is also discussed. Four main photocaging scaffolds are presented in detail, o-nitrobenzyls, p-hydroxyphenyls, coumarinyls and nitrodibenzofuranyls, along with three examples of the use of this technology. Furthermore, a subset of specialty photocages are highlighted: photoacids, molecular photoswitches and metal-containing photocages. These extend the range of photocaging approaches by, for example, controlling pH or generating conformationally locked molecules." @default.
- W3204285940 created "2021-10-11" @default.
- W3204285940 creator A5028459620 @default.
- W3204285940 creator A5029127264 @default.
- W3204285940 creator A5032687666 @default.
- W3204285940 creator A5037128193 @default.
- W3204285940 date "2021-09-22" @default.
- W3204285940 modified "2023-10-14" @default.
- W3204285940 title "Using photocaging for fast time-resolved structural biology studies" @default.
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