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• W3204287242 abstract "Abstract Background The rising consensus that the cell can dynamically allocate its resources provides an interesting angle for discovering the governing principles of cell growth and metabolism. Extensive efforts have been made in the past decade to elucidate the relationship between resource allocation and phenotypic patterns of microorganisms. Despite these exciting developments, there is still a lack of explicit comparison between potentially competing propositions and a lack of synthesis of inter-related proposals and findings. Results In this work, we have reviewed resource allocation-derived principles, hypotheses and mathematical models to recapitulate important achievements in this area. In particular, the emergence of resource allocation phenomena is deciphered by the putative tug of war between the cellular objectives, demands and the supply capability. Competing hypotheses for explaining the most-studied phenomenon arising from resource allocation, i.e. the overflow metabolism, have been re-examined towards uncovering the potential physiological root cause. The possible link between proteome fractions and the partition of the ribosomal machinery has been analysed through mathematical derivations. Finally, open questions are highlighted and an outlook on the practical applications is provided. It is the authors’ intention that this review contributes to a clearer understanding of the role of resource allocation in resolving bacterial growth strategies, one of the central questions in microbiology. Conclusions We have shown the importance of resource allocation in understanding various aspects of cellular systems. Several important questions such as the physiological root cause of overflow metabolism and the correct interpretation of ‘protein costs’ are shown to remain open. As the understanding of the mechanisms and utility of resource application in cellular systems further develops, we anticipate that mathematical modelling tools incorporating resource allocation will facilitate the circuit-host design in synthetic biology." @default.
• W3204287242 created "2021-10-11" @default.
• W3204287242 creator A5000871229 @default.
• W3204287242 creator A5034467905 @default.
• W3204287242 creator A5067371740 @default.
• W3204287242 creator A5080704095 @default.
• W3204287242 date "2021-09-28" @default.
• W3204287242 modified "2023-10-09" @default.
• W3204287242 title "Understanding and mathematical modelling of cellular resource allocation in microorganisms: a comparative synthesis" @default.
• W3204287242 cites W1579467601 @default.
• W3204287242 cites W1758395617 @default.
• W3204287242 cites W1799738555 @default.
• W3204287242 cites W1905129103 @default.
• W3204287242 cites W1950998267 @default.
• W3204287242 cites W1965305472 @default.
• W3204287242 cites W1966645118 @default.
• W3204287242 cites W1971866274 @default.
• W3204287242 cites W1972863608 @default.
• W3204287242 cites W1977688694 @default.
• W3204287242 cites W1985161570 @default.
• W3204287242 cites W2008681679 @default.
• W3204287242 cites W2016381905 @default.
• W3204287242 cites W2018620177 @default.
• W3204287242 cites W2022264229 @default.
• W3204287242 cites W2030098073 @default.
• W3204287242 cites W2034494369 @default.
• W3204287242 cites W2036449301 @default.
• W3204287242 cites W2036864888 @default.
• W3204287242 cites W2037248648 @default.
• W3204287242 cites W2037462150 @default.
• W3204287242 cites W2037913229 @default.
• W3204287242 cites W2041715023 @default.
• W3204287242 cites W2042632725 @default.
• W3204287242 cites W2042638652 @default.
• W3204287242 cites W2044463066 @default.
• W3204287242 cites W2048596643 @default.
• W3204287242 cites W2054087105 @default.
• W3204287242 cites W2072447727 @default.
• W3204287242 cites W2076477598 @default.
• W3204287242 cites W2078355959 @default.
• W3204287242 cites W2080365353 @default.
• W3204287242 cites W2081781433 @default.
• W3204287242 cites W2082982706 @default.
• W3204287242 cites W2088349621 @default.
• W3204287242 cites W2088550607 @default.
• W3204287242 cites W2091312350 @default.
• W3204287242 cites W2097259163 @default.
• W3204287242 cites W2104187897 @default.
• W3204287242 cites W2104413400 @default.
• W3204287242 cites W2107275175 @default.
• W3204287242 cites W2116980992 @default.
• W3204287242 cites W2118464978 @default.
• W3204287242 cites W2122860350 @default.
• W3204287242 cites W2123782813 @default.
• W3204287242 cites W2138235490 @default.
• W3204287242 cites W2148899088 @default.
• W3204287242 cites W2149033595 @default.
• W3204287242 cites W2153501719 @default.
• W3204287242 cites W2157457604 @default.
• W3204287242 cites W2165981599 @default.
• W3204287242 cites W2168360074 @default.
• W3204287242 cites W2170298003 @default.
• W3204287242 cites W2191824721 @default.
• W3204287242 cites W2416065856 @default.
• W3204287242 cites W2465128457 @default.
• W3204287242 cites W2468889898 @default.
• W3204287242 cites W2501736566 @default.
• W3204287242 cites W2506127557 @default.
• W3204287242 cites W2523512393 @default.
• W3204287242 cites W2531281183 @default.
• W3204287242 cites W2571702114 @default.
• W3204287242 cites W2730330710 @default.
• W3204287242 cites W2736780095 @default.
• W3204287242 cites W2737557435 @default.
• W3204287242 cites W2743063996 @default.
• W3204287242 cites W2759254532 @default.
• W3204287242 cites W2765678962 @default.
• W3204287242 cites W2765912798 @default.
• W3204287242 cites W2767089562 @default.
• W3204287242 cites W2783185708 @default.
• W3204287242 cites W2786627077 @default.
• W3204287242 cites W2787133039 @default.
• W3204287242 cites W2790057102 @default.
• W3204287242 cites W2793598149 @default.
• W3204287242 cites W2794889462 @default.
• W3204287242 cites W2883474940 @default.
• W3204287242 cites W2904427689 @default.
• W3204287242 cites W2914198426 @default.
• W3204287242 cites W2914450080 @default.
• W3204287242 cites W2921508993 @default.
• W3204287242 cites W2922405027 @default.
• W3204287242 cites W2939762195 @default.
• W3204287242 cites W2950803758 @default.
• W3204287242 cites W2950814208 @default.
• W3204287242 cites W2951198452 @default.
• W3204287242 cites W2951697204 @default.
• W3204287242 cites W2952266006 @default.
• W3204287242 cites W2962724228 @default.
• W3204287242 cites W2962760960 @default.
• W3204287242 cites W2967764163 @default.

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