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• W3204287311 abstract "Pacinian corpuscle is a low threshold mechanoreceptor involved in the sensation of pressure, touch, and vibration. Its structure comprises a capsule, flat cells (Schwann-like glial cells, or lamellar cells) arranged in a concentric pattern of about 30 lamellae and a central core with an axon terminal.1Bentivoglio M. Pacini P. Filippo Pacini—a determined observer.Brain Res Bull. 1995; 38: 161-165Crossref PubMed Scopus (42) Google Scholar,2Cobo R. García-Piqueras J. Cobo J. Vega J.A. The human cutaneous sensory corpuscles: an update.J Clin Med. 2021; 10: 227Crossref Scopus (8) Google Scholar Pacinian corpuscles are commonly seen in dermis and subcutaneous tissues of the hands and feet and the digits, arm, neck, mesenteries, near joints, nipples, external genitalia, and periosteal and interosseous membranes.3Kettenmann H. Nervous system.in: Standring S. Gray’s Anatomy: The Anatomical Basis of Clinical Practice. 41st ed. Elsevier, Amsterdam2016: 61Google Scholar They are exceptionally rare in other locations and have been documented in urinary bladder, pancreas, lymph nodes and thymus.4Landon D.N. Wiseman O.J. A Pacinian corpuscle in the human bladder lamina propria.J Neurocytol. 2001; 30: 457-464Crossref PubMed Scopus (10) Google Scholar, 5Standop J. Ulrich A. Schneider M.B. Andrén-Sandberg A. Pour P.M. Pacinian corpuscle in the human pancreas.Pancreas. 2001; 23: 36-39Crossref PubMed Scopus (9) Google Scholar, 6Aydin O. Pacinian corpuscle in a lymph node.Neuropathology. 2006; 26: 379-381Crossref PubMed Scopus (7) Google Scholar, 7Varga I. Nosál M. Babál P. Ectopic lamellar Pacinian corpuscle within the thymus. Atypical or abnormal location?.Rom J Morphol Embryol. 2020; 61: 273-276Crossref PubMed Scopus (1) Google Scholar They have also been observed in developmental disorders such as meningoradiculoceles and cervical chondrocutaneous rests.8Gessi M. Messing-Jünger M. Röhrig A. Gielen G.H. Pietsch T. van Landeghem F.K. Incidental neuropathological findings in a child with cervical meningoradiculocele.Brain Pathol. 2012; 22: 737-740Crossref PubMed Scopus (2) Google Scholar,9Feito J. Ramos-García J.L. Gago Á. et al.Pacinian corpuscles in a cervical chondrocutaneous remnant: a case report and update of Pacinian corpuscles.Am J Dermatopathol. 2016; 38: 231-235Crossref PubMed Scopus (13) Google Scholar We are aware of two previous reports of Pacinian corpuscles in the prostate,10Pai S.A. Ectopic Pacinian corpuscle in the prostate.Int J Surg Pathol. 2017; 25: 609-610Crossref PubMed Scopus (8) Google Scholar,11Medlicott S.A.C. Larsen E.T. Gao Y. Trpkov K. Pacinian corpuscle in the prostate: fact - not fiction!.Hum Pathol Case Rep. 2019; 15: 71-72Crossref Scopus (2) Google Scholar both of which were not in clear intraprostatic location. We report herein the finding of a radical prostatectomy specimen from a 64-year-old patient. It showed a prostatic adenocarcinoma, Gleason score 9 (4+5) (Grade group 5), with extraprostatic extension (pT3a). On microscopy, the periphery of the right apex showed—in addition to extensive prostatic malignancy—one bulbous onion-like formation measuring 1 mm (maximum diameter) in obvious intraprostatic location (Fig. 1). The corpuscle was located 0.5 mm deep from the external boundary of the prostate. Clinical history was unremarkable. In the case reported by Medlicott and colleagues, two corpuscles were described as located in the periphery of mid-gland and, based on the photomicrograph, at least one of them was in the extraprostatic tissue.10Pai S.A. Ectopic Pacinian corpuscle in the prostate.Int J Surg Pathol. 2017; 25: 609-610Crossref PubMed Scopus (8) Google Scholar In the first report of prostatic Pacinian corpuscle, location and level of occurrence was not provided although the photomicrograph suggests the presence of adipose (extraprostatic) tissue surrounding the structure.11Medlicott S.A.C. Larsen E.T. Gao Y. Trpkov K. Pacinian corpuscle in the prostate: fact - not fiction!.Hum Pathol Case Rep. 2019; 15: 71-72Crossref Scopus (2) Google Scholar Extraprostatic tissue is known to harbour numerous and large paraganglia. In the bladder, Pacinian corpuscle can be seen within large paraganglia during the first months of life. In specimens of children older than 5 months, these structures are only seen separate12Dixon J.S. Gosling J.A. Canning D.A. Gearhart J.P. An immunohistochemical study of human postnatal paraganglia associated with the urinary bladder.J Anat. 1992; 181: 431-436PubMed Google Scholar. This observation suggests that paraganglia may be involved in the differentiation of Pacinian corpuscle during development. However, Pacinian corpuscles are exceptionally rare in the urinary bladder of adults.4Landon D.N. Wiseman O.J. A Pacinian corpuscle in the human bladder lamina propria.J Neurocytol. 2001; 30: 457-464Crossref PubMed Scopus (10) Google Scholar We confirm the occurrence of Pacinian corpuscles within intraprostatic tissues (Fig. 1). In all three documented cases to date, Pacinian corpuscles were surrounded by high-grade invasive acinar adenocarcinoma. Awareness of variations of normal histology is important to avoid misinterpretation of unusual findings. The authors state that there are no conflicts of interest to disclose." @default.
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• W3204287311 date "2022-06-01" @default.
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• W3204287311 title "Intraprostatic Pacinian corpuscle does exist!" @default.
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