FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204294250> ?p ?o ?g. }

• W3204294250 endingPage "450" @default.
• W3204294250 startingPage "433" @default.
• W3204294250 abstract "Both external beam radiation therapy (EBRT) and selective-internal radiation therapy (SIRT) are implemented to treat unresectable intrahepatic cholangiocarcinoma (iCCA). The present study aimed to evaluate the efficacy of EBRT and SIRT in managing iCCA through a systematic review and meta-analysis.PubMed and Cochrane database were queried to search for studies published from January 2000 toJune 2020 without language restrictions. Median survival time, overall survival, and radiological response were extracted. Secondary outcomes such as complication rates, predictors of survival, and downstage to surgery were pooled. Patient-level survival data were obtained to generate Kaplan-Meier survival graph. Pooled outcomes were analyzed with a random-effect model.Twenty-nine and 20 studies including 732 and 443 patients from the SIRT and EBRT groups were included in the present study. From initial radiation treatment, the median survival time for patients who underwent SIRT and EBRT were 12.0 (95% confidence interval [CI]: 10.8-14.6) and 13.6 (95% CI: 11.1-16.0) months, respectively. As first-line therapy, the median survival time was 36.1 (95% CI: 20.6-39.5) months for SIRT and 11.0 (95% CI: 9.3-13.6) months for EBRT. Both radiation modalities were effective in downstaging initially unresectable iCCA to surgery (SIRT: 30.5%; EBRT: 18.3%). Patients in the SIRT group encountered more post-embolization abdominal pain (6.9 vs. 2.2%), ulcer (1.0 vs. 0.5%), nausea (1.6 vs. 0.7%), anorexia (5.9 vs. 0%), thrombocytopenia (7.3 vs. 6.0%), hyperbilirubinemia (5.2 vs. 2.1%), and hypoalbuminemia (13.2 vs. 3.3%), whereas EBRT was associated with higher rates of anemia (0.6 vs. 7.5%) and neutropenia (6.5 vs. 11.0%).Both EBRT and SIRT were safe and effective in treating unresectable iCCA. However, available evidence was highly heterogeneous regarding patient population, limiting fair comparison between 2 radiation modalities. Future high-quality comparative studies are warranted." @default.
• W3204294250 created "2021-10-11" @default.
• W3204294250 creator A5034982613 @default.
• W3204294250 creator A5054555044 @default.
• W3204294250 creator A5064430862 @default.
• W3204294250 creator A5073565162 @default.
• W3204294250 date "2021-01-01" @default.
• W3204294250 modified "2023-10-05" @default.
• W3204294250 title "Twenty Years of Radiation Therapy of Unresectable Intrahepatic Cholangiocarinoma: Internal or External? A Systematic Review and Meta-Analysis" @default.
• W3204294250 cites W124144930 @default.
• W3204294250 cites W1504363060 @default.
• W3204294250 cites W1510049477 @default.
• W3204294250 cites W1651736482 @default.
• W3204294250 cites W1843348728 @default.
• W3204294250 cites W1963570372 @default.
• W3204294250 cites W1974272351 @default.
• W3204294250 cites W1975836447 @default.
• W3204294250 cites W1978614884 @default.
• W3204294250 cites W1991701933 @default.
• W3204294250 cites W1992563364 @default.
• W3204294250 cites W2000110733 @default.
• W3204294250 cites W2011387799 @default.
• W3204294250 cites W2020567724 @default.
• W3204294250 cites W2025958291 @default.
• W3204294250 cites W2027582694 @default.
• W3204294250 cites W2032099469 @default.
• W3204294250 cites W2032850947 @default.
• W3204294250 cites W2036558320 @default.
• W3204294250 cites W2047314052 @default.
• W3204294250 cites W2052612572 @default.
• W3204294250 cites W2064434671 @default.
• W3204294250 cites W2066597933 @default.
• W3204294250 cites W2069252841 @default.
• W3204294250 cites W2073467830 @default.
• W3204294250 cites W2073724631 @default.
• W3204294250 cites W2075157566 @default.
• W3204294250 cites W2078797029 @default.
• W3204294250 cites W2084440537 @default.
• W3204294250 cites W2089242758 @default.
• W3204294250 cites W2090483604 @default.
• W3204294250 cites W2095101789 @default.
• W3204294250 cites W2104414799 @default.
• W3204294250 cites W2119442895 @default.
• W3204294250 cites W2122047548 @default.
• W3204294250 cites W2125047757 @default.
• W3204294250 cites W2129322549 @default.
• W3204294250 cites W2136984843 @default.
• W3204294250 cites W2144715281 @default.
• W3204294250 cites W2149686378 @default.
• W3204294250 cites W2152955393 @default.
• W3204294250 cites W2198248975 @default.
• W3204294250 cites W2210550576 @default.
• W3204294250 cites W2384304121 @default.
• W3204294250 cites W2416923768 @default.
• W3204294250 cites W2467932635 @default.
• W3204294250 cites W2501017081 @default.
• W3204294250 cites W2513294598 @default.
• W3204294250 cites W2557092829 @default.
• W3204294250 cites W2571104554 @default.
• W3204294250 cites W2573506914 @default.
• W3204294250 cites W2590640172 @default.
• W3204294250 cites W2606106498 @default.
• W3204294250 cites W2612400171 @default.
• W3204294250 cites W2742841145 @default.
• W3204294250 cites W2767010589 @default.
• W3204294250 cites W2771619777 @default.
• W3204294250 cites W2774420993 @default.
• W3204294250 cites W2781716206 @default.
• W3204294250 cites W2789189349 @default.
• W3204294250 cites W2790076076 @default.
• W3204294250 cites W2793317809 @default.
• W3204294250 cites W2793907317 @default.
• W3204294250 cites W2809830289 @default.
• W3204294250 cites W2914697371 @default.
• W3204294250 cites W2938034283 @default.
• W3204294250 cites W2953729061 @default.
• W3204294250 cites W2964116848 @default.
• W3204294250 cites W2965142538 @default.
• W3204294250 cites W2969836739 @default.
• W3204294250 cites W2977666110 @default.
• W3204294250 cites W2982321050 @default.
• W3204294250 cites W2993292298 @default.
• W3204294250 cites W2995254412 @default.
• W3204294250 cites W2997457530 @default.
• W3204294250 cites W2998072373 @default.
• W3204294250 cites W3013605866 @default.
• W3204294250 cites W3028924526 @default.
• W3204294250 cites W3029967286 @default.
• W3204294250 cites W952389843 @default.
• W3204294250 doi "https://doi.org/10.1159/000516880" @default.
• W3204294250 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8527917" @default.
• W3204294250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34721506" @default.
• W3204294250 hasPublicationYear "2021" @default.
• W3204294250 type Work @default.
• W3204294250 sameAs 3204294250 @default.
• W3204294250 citedByCount "6" @default.
• W3204294250 countsByYear W32042942502021 @default.
• W3204294250 countsByYear W32042942502022 @default.

• next