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- W3204303250 endingPage "107990" @default.
- W3204303250 startingPage "107990" @default.
- W3204303250 abstract "Antimicrobial peptides (AMPs) are potent, mostly cationic, and amphiphilic broad-spectrum host defense antimicrobials that are produced by all organisms ranging from prokaryotes to humans. In addition to their antimicrobial actions, they modulate inflammatory and immune responses and promote wound healing. Although they have clear benefits over traditional antibiotic drugs, their wide therapeutic utilization is compromised by concerns of toxicity, stability, and production costs. Recent advances in nanotechnology have attracted increasing interest to unleash the AMPs' immense potential as broad-spectrum antibiotics and anti-biofilm agents, against which the bacteria have less chances to develop resistance. Topical application of AMPs promotes migration of keratinocytes and fibroblasts, and contributes significantly to an accelerated wound healing process. Delivery of AMPs by employing nanotechnological approaches avoids the major disadvantages of AMPs, such as instability and toxicity, and provides a controlled delivery profile together with prolonged activity. In this review, we provide an overview of the key properties of AMPs and discuss the latest developments in topical AMP therapy using nanocarriers. We use chronic hard-to-heal wounds-complicated by infections, inflammation, and stagnated healing-as an example of an unmet medical need for which the AMPs' wide range of therapeutic actions could provide the most potential benefit. The use of innovative materials and sophisticated nanotechnological approaches offering various possibilities are discussed in more depth." @default.
- W3204303250 created "2021-10-11" @default.
- W3204303250 creator A5042890653 @default.
- W3204303250 creator A5082077763 @default.
- W3204303250 creator A5082344406 @default.
- W3204303250 date "2022-04-01" @default.
- W3204303250 modified "2023-09-30" @default.
- W3204303250 title "Antimicrobial peptides – Unleashing their therapeutic potential using nanotechnology" @default.
- W3204303250 cites W1487871178 @default.
- W3204303250 cites W1501578503 @default.
- W3204303250 cites W1506297407 @default.
- W3204303250 cites W1520340830 @default.
- W3204303250 cites W1532795681 @default.
- W3204303250 cites W1568146516 @default.
- W3204303250 cites W1571292455 @default.
- W3204303250 cites W1576016841 @default.
- W3204303250 cites W1576571210 @default.
- W3204303250 cites W1586147500 @default.
- W3204303250 cites W1590183001 @default.
- W3204303250 cites W1728413725 @default.
- W3204303250 cites W1732204574 @default.
- W3204303250 cites W1853529910 @default.
- W3204303250 cites W1860703355 @default.
- W3204303250 cites W1880461483 @default.
- W3204303250 cites W1883676910 @default.
- W3204303250 cites W1907221839 @default.
- W3204303250 cites W1942354720 @default.
- W3204303250 cites W1954606945 @default.
- W3204303250 cites W1957987376 @default.
- W3204303250 cites W1964758221 @default.
- W3204303250 cites W1966337984 @default.
- W3204303250 cites W1966819617 @default.
- W3204303250 cites W1967069761 @default.
- W3204303250 cites W1968820299 @default.
- W3204303250 cites W1969351704 @default.
- W3204303250 cites W1970356261 @default.
- W3204303250 cites W1970399857 @default.
- W3204303250 cites W1971981119 @default.
- W3204303250 cites W1973437332 @default.
- W3204303250 cites W1973750177 @default.
- W3204303250 cites W1974194706 @default.
- W3204303250 cites W1974279969 @default.
- W3204303250 cites W1977350191 @default.
- W3204303250 cites W1978359304 @default.
- W3204303250 cites W1978713113 @default.
- W3204303250 cites W1979156924 @default.
- W3204303250 cites W1979962636 @default.
- W3204303250 cites W1983836077 @default.
- W3204303250 cites W1984417662 @default.
- W3204303250 cites W1985533655 @default.
- W3204303250 cites W1986308133 @default.
- W3204303250 cites W1986645374 @default.
- W3204303250 cites W1987312039 @default.
- W3204303250 cites W1987699989 @default.
- W3204303250 cites W1988052373 @default.
- W3204303250 cites W1988877336 @default.
- W3204303250 cites W1989675926 @default.
- W3204303250 cites W1989998611 @default.
- W3204303250 cites W1990761952 @default.
- W3204303250 cites W1992034405 @default.
- W3204303250 cites W1992861059 @default.
- W3204303250 cites W1994141994 @default.
- W3204303250 cites W1995346352 @default.
- W3204303250 cites W1996023151 @default.
- W3204303250 cites W1996260034 @default.
- W3204303250 cites W1997228131 @default.
- W3204303250 cites W2000624507 @default.
- W3204303250 cites W2002288900 @default.
- W3204303250 cites W2003112779 @default.
- W3204303250 cites W2009106357 @default.
- W3204303250 cites W2009445151 @default.
- W3204303250 cites W2011461366 @default.
- W3204303250 cites W2011615074 @default.
- W3204303250 cites W2013133956 @default.
- W3204303250 cites W2013621172 @default.
- W3204303250 cites W2014865051 @default.
- W3204303250 cites W2015823644 @default.
- W3204303250 cites W2017328736 @default.
- W3204303250 cites W2020414349 @default.
- W3204303250 cites W2020799333 @default.
- W3204303250 cites W2021776656 @default.
- W3204303250 cites W2022328403 @default.
- W3204303250 cites W2023617736 @default.
- W3204303250 cites W2025208643 @default.
- W3204303250 cites W2027074022 @default.
- W3204303250 cites W2027146754 @default.
- W3204303250 cites W2027991714 @default.
- W3204303250 cites W2028869026 @default.
- W3204303250 cites W2031962541 @default.
- W3204303250 cites W2033278174 @default.
- W3204303250 cites W2033667314 @default.
- W3204303250 cites W2038058861 @default.
- W3204303250 cites W2040555856 @default.
- W3204303250 cites W2040597252 @default.
- W3204303250 cites W2041837819 @default.
- W3204303250 cites W2041942794 @default.
- W3204303250 cites W2041958543 @default.
- W3204303250 cites W2043346968 @default.