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• W3204303792 abstract "<h3>Background</h3> The available evidence on the use of Direct Antiglobulin test (DAT) in management of neonatal hyperbilirubinemia are conflicting. <h3>Objectives</h3> To assess if the strength of positive Direct Antiglobulin test (DAT) predicts the need for phototherapy, duration of phototherapy and need for major interventions. <h3>Methods</h3> This was a retrospective single center study conducted over a period of six years (2014–2019). We collected data on all DAT positive neonates ≥32 weeks. Data regarding blood group, DAT and clinical details were obtained from hospital database. We also collected data on serial haemoglobin and other relevant laboratory parameters. Irrespective of DAT status we also collected data on infants receiving major interventions like exchange transfusion, in-utero transfusion, immunoglobulins and postnatal transfusion for the duration of the study period. All of these infants were electronically followed up for a period of 6 weeks. This study was approved by institutional audit authority. All the statistics were performed using SPSS software. <h3>Results</h3> A total of 1285 DAT tests were performed during this time frame. Out this, 91 infants were DAT positive (7%), and 78 DAT positive infants were available for analysis. 72% of the study population were >37 weeks of gestation. There were 54 infants with DAT (1+), 15 infants with DAT (2+), 7 infants with DAT (3+) and 2 infants with DAT (4+). There was no significant difference in terms of need for phototherapy, duration of phototherapy, need for major interventions and haemoglobin levels at different time points between the groups (DAT 1+ Vs DAT ≥2+; DAT 2+ Vs DAT≥3+). Total of 10 infants received major interventions, with one infant receiving all three interventions (DAT 3+ with significant maternal antibodies), 2 infants (both DAT1+) received exchange transfusion, 6 infants received immunoglobulin (2 infants: DAT 2+; 4 infants: DAT 1+) and one infant (DAT 1+) with significant maternal antibodies received postnatal transfusion. <h3>Conclusions</h3> The strength of DAT did not predict the need for phototherapy, duration of phototherapy, and need for major haemolysis related intervention in the first six weeks of life." @default.
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• W3204303792 date "2021-09-30" @default.
• W3204303792 modified "2023-09-25" @default.
• W3204303792 title "731 Does the strengths of positive direct antiglobulin test predict the need for phototherapy and duration of phototherapy?" @default.
• W3204303792 doi "https://doi.org/10.1136/archdischild-2021-rcpch.168" @default.
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