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- W3204304440 endingPage "4986" @default.
- W3204304440 startingPage "4986" @default.
- W3204304440 abstract "Glioblastoma (GBM) is the most prevalent, aggressive primary brain tumour with a dismal prognosis. Treatment at diagnosis has limited efficacy and there is no standardised treatment at recurrence. New, personalised treatment options are under investigation, although challenges persist for heterogenous tumours such as GBM. Gene editing technologies are a game changer, enabling design of novel molecular-immunological treatments to be used in combination with chemoradiation, to achieve long lasting survival benefits for patients. Here, we review the literature on how cutting-edge molecular gene editing technologies can be applied to known and emerging tumour-associated antigens to enhance chimeric antigen receptor T and NK cell therapies for GBM. A tight balance of limiting neurotoxicity, avoiding tumour antigen loss and therapy resistance, while simultaneously promoting long-term persistence of the adoptively transferred cells must be maintained to significantly improve patient survival. We discuss the opportunities and challenges posed by the brain contexture to the administration of the treatments and achieving sustained clinical responses." @default.
- W3204304440 created "2021-10-11" @default.
- W3204304440 creator A5012134047 @default.
- W3204304440 creator A5016537093 @default.
- W3204304440 creator A5087890221 @default.
- W3204304440 date "2021-10-05" @default.
- W3204304440 modified "2023-09-29" @default.
- W3204304440 title "Challenges and Prospects for Designer T and NK Cells in Glioblastoma Immunotherapy" @default.
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