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• W3204307086 abstract "GNAS encodes the Gαs (stimulatory G-protein alpha subunit) protein, which mediates G protein–coupled receptor (GPCR) signaling. GNAS mutations cause developmental delay, short stature, and skeletal abnormalities in a syndrome called Albright’s hereditary osteodystrophy. Because of imprinting, mutations on the maternal allele also cause obesity and hormone resistance (pseudohypoparathyroidism)." @default.
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• W3204307086 date "2021-10-21" @default.
• W3204307086 modified "2023-09-29" @default.
• W3204307086 title "Obesity-Associated <i>GNAS</i> Mutations and the Melanocortin Pathway" @default.
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• W3204307086 doi "https://doi.org/10.1056/nejmoa2103329" @default.
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