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- W3204308666 endingPage "108204" @default.
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- W3204308666 abstract "Acute lung injury (ALI) is a life-threatening syndrome that possibly leads to high morbidity and mortality as no therapy exists. Several natural ingredients with negligible adverse effects have recently been investigated to possibly inhibit the inflammatory pathways associated with ALI at the molecular level. Isoflavones, as phytoestrogenic compounds, are naturally occurring bioactive compounds that represent the most abundant category of plant polyphenols (Leguminosae family). A broad range of therapeutic activities of isoflavones, including antioxidants, chemopreventive, anti-inflammatory, antiallergic and antibacterial potentials, have been extensively documented in the literature. Our review exclusively focuses on the possible anti-inflammatory, antioxidant role of botanicals'-derived isoflavones against ALI and their immunomodulatory effect in experimentally induced ALI. Despite the limited scope covering their molecular mechanisms, isoflavones substantially contributed to protecting from ALI via inhibiting toll-like receptor 4 (TLR4)/Myd88/NF-κB pathway and subsequent cytokines, chemokines, and adherent proteins. Nonetheless, future research is suggested to fill the gap in elucidating the protective roles of isoflavones to alleviate ALI concerning antioxidant potentials, inhibition of the inflammatory pathways, and associated molecular mechanisms." @default.
- W3204308666 created "2021-10-11" @default.
- W3204308666 creator A5010147041 @default.
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- W3204308666 creator A5025513114 @default.
- W3204308666 creator A5053758585 @default.
- W3204308666 creator A5081938861 @default.
- W3204308666 date "2021-12-01" @default.
- W3204308666 modified "2023-09-27" @default.
- W3204308666 title "Potential therapeutic interventions of plant–derived isoflavones against acute lung injury" @default.
- W3204308666 cites W1482266658 @default.
- W3204308666 cites W1531257775 @default.
- W3204308666 cites W1849840946 @default.
- W3204308666 cites W1883178470 @default.
- W3204308666 cites W1940800221 @default.
- W3204308666 cites W1955787339 @default.
- W3204308666 cites W1967648355 @default.
- W3204308666 cites W1968294667 @default.
- W3204308666 cites W1974375115 @default.
- W3204308666 cites W1976881822 @default.
- W3204308666 cites W1978083802 @default.
- W3204308666 cites W1980087831 @default.
- W3204308666 cites W1981949220 @default.
- W3204308666 cites W1981999470 @default.
- W3204308666 cites W1982155022 @default.
- W3204308666 cites W1986969704 @default.
- W3204308666 cites W1988268961 @default.
- W3204308666 cites W1992598095 @default.
- W3204308666 cites W1994008133 @default.
- W3204308666 cites W1996397579 @default.
- W3204308666 cites W1997791747 @default.
- W3204308666 cites W1998457189 @default.
- W3204308666 cites W2000103162 @default.
- W3204308666 cites W2001174264 @default.
- W3204308666 cites W2005357317 @default.
- W3204308666 cites W2007454584 @default.
- W3204308666 cites W2008906556 @default.
- W3204308666 cites W2011821684 @default.
- W3204308666 cites W2011840777 @default.
- W3204308666 cites W2018414972 @default.
- W3204308666 cites W2020265991 @default.
- W3204308666 cites W2022779434 @default.
- W3204308666 cites W2026072651 @default.
- W3204308666 cites W2038819083 @default.
- W3204308666 cites W2043734144 @default.
- W3204308666 cites W2047134550 @default.
- W3204308666 cites W2051165350 @default.
- W3204308666 cites W2051921682 @default.
- W3204308666 cites W2052150889 @default.
- W3204308666 cites W2056932288 @default.
- W3204308666 cites W2057155665 @default.
- W3204308666 cites W2057418463 @default.
- W3204308666 cites W2065275725 @default.
- W3204308666 cites W2066057720 @default.
- W3204308666 cites W2069905289 @default.
- W3204308666 cites W2072431465 @default.
- W3204308666 cites W2073603071 @default.
- W3204308666 cites W2074359472 @default.
- W3204308666 cites W2075264042 @default.
- W3204308666 cites W2075330627 @default.
- W3204308666 cites W2076245674 @default.
- W3204308666 cites W2076941943 @default.
- W3204308666 cites W2078668520 @default.
- W3204308666 cites W2080010576 @default.
- W3204308666 cites W2080138182 @default.
- W3204308666 cites W2081425476 @default.
- W3204308666 cites W2082966150 @default.
- W3204308666 cites W2083296681 @default.
- W3204308666 cites W2085421567 @default.
- W3204308666 cites W2090790151 @default.
- W3204308666 cites W2091273694 @default.
- W3204308666 cites W2092973313 @default.
- W3204308666 cites W2093084020 @default.
- W3204308666 cites W2094064915 @default.
- W3204308666 cites W2095691079 @default.
- W3204308666 cites W2097728369 @default.
- W3204308666 cites W2101170062 @default.
- W3204308666 cites W2105637778 @default.
- W3204308666 cites W2115573340 @default.
- W3204308666 cites W2115672224 @default.
- W3204308666 cites W2116659630 @default.
- W3204308666 cites W2117990011 @default.
- W3204308666 cites W2125241840 @default.
- W3204308666 cites W2132041842 @default.
- W3204308666 cites W2133710256 @default.
- W3204308666 cites W2134258307 @default.
- W3204308666 cites W2141686795 @default.
- W3204308666 cites W2142656747 @default.
- W3204308666 cites W2142994668 @default.
- W3204308666 cites W2144868623 @default.
- W3204308666 cites W2145963591 @default.
- W3204308666 cites W2148321601 @default.
- W3204308666 cites W2150179581 @default.
- W3204308666 cites W2153791073 @default.
- W3204308666 cites W2157495240 @default.
- W3204308666 cites W2159030449 @default.
- W3204308666 cites W2165102783 @default.
- W3204308666 cites W2169981866 @default.