FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204309882> ?p ?o ?g. }

• W3204309882 abstract "Tuberous sclerosis complex (TSC) is an autosomal dominant cancer predisposition disorder caused by heterozygous mutations in TSC1 or TSC2 genes and characterized by mTORC1 hyperactivation. TSC-associated tumors develop after loss of heterozygosity mutations and their treatment involves the use of mTORC1 inhibitors. We aimed to evaluate cellular processes regulated by mTORC1 in TSC cells with different mutations before tumor development. Flow cytometry analyses were performed to evaluate cell viability, cell cycle and autophagy in non-tumor primary TSC cells with different heterozygous mutations and in control cells without TSC mutations, before and after treatment with rapamycin (mTORC1 inhibitor). We did not observe differences in cell viability and cell cycle between the cell groups. However, autophagy was reduced in mutated cells. After rapamycin treatment, mutated cells showed a significant increase in the autophagy process (p=0.039). We did not observe differences between cells with distinct TSC mutations. Our main finding is the alteration of autophagy in non-tumor TSC cells. Previous studies in literature found autophagy alterations in tumor TSC cells or knock-out animal models. We showed that autophagy could be an important mechanism that leads to TSC tumor formation in the haploinsufficiency state. This result could guide future studies in this field." @default.
• W3204309882 created "2021-10-11" @default.
• W3204309882 creator A5003435839 @default.
• W3204309882 creator A5030085949 @default.
• W3204309882 creator A5034378478 @default.
• W3204309882 creator A5034971594 @default.
• W3204309882 creator A5044929823 @default.
• W3204309882 creator A5060027275 @default.
• W3204309882 creator A5062770007 @default.
• W3204309882 creator A5085356021 @default.
• W3204309882 creator A5091641049 @default.
• W3204309882 date "2021-01-01" @default.
• W3204309882 modified "2023-10-16" @default.
• W3204309882 title "Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state" @default.
• W3204309882 cites W1978972459 @default.
• W3204309882 cites W1981912182 @default.
• W3204309882 cites W1994823455 @default.
• W3204309882 cites W2002636911 @default.
• W3204309882 cites W2003523238 @default.
• W3204309882 cites W2005235901 @default.
• W3204309882 cites W2008294451 @default.
• W3204309882 cites W2009971408 @default.
• W3204309882 cites W2014058353 @default.
• W3204309882 cites W2016888102 @default.
• W3204309882 cites W2024400885 @default.
• W3204309882 cites W2025617594 @default.
• W3204309882 cites W2039607936 @default.
• W3204309882 cites W2077858999 @default.
• W3204309882 cites W2077926379 @default.
• W3204309882 cites W2081057817 @default.
• W3204309882 cites W2082131764 @default.
• W3204309882 cites W2089193884 @default.
• W3204309882 cites W2102354517 @default.
• W3204309882 cites W2105284688 @default.
• W3204309882 cites W2115886998 @default.
• W3204309882 cites W2116542833 @default.
• W3204309882 cites W2117849574 @default.
• W3204309882 cites W2124946605 @default.
• W3204309882 cites W2126127189 @default.
• W3204309882 cites W2127219942 @default.
• W3204309882 cites W2138544728 @default.
• W3204309882 cites W2139802897 @default.
• W3204309882 cites W2144323242 @default.
• W3204309882 cites W2156144699 @default.
• W3204309882 cites W2157197322 @default.
• W3204309882 cites W2285098929 @default.
• W3204309882 cites W2295029841 @default.
• W3204309882 cites W2324750755 @default.
• W3204309882 cites W2383259826 @default.
• W3204309882 cites W2470189540 @default.
• W3204309882 cites W2620450752 @default.
• W3204309882 cites W2763611766 @default.
• W3204309882 cites W2768024482 @default.
• W3204309882 cites W2770093701 @default.
• W3204309882 cites W2912059266 @default.
• W3204309882 cites W3009543498 @default.
• W3204309882 cites W3022134163 @default.
• W3204309882 doi "https://doi.org/10.1590/1678-4685-gmb-2020-0475" @default.
• W3204309882 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8515215" @default.
• W3204309882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34609442" @default.
• W3204309882 hasPublicationYear "2021" @default.
• W3204309882 type Work @default.
• W3204309882 sameAs 3204309882 @default.
• W3204309882 citedByCount "0" @default.
• W3204309882 crossrefType "journal-article" @default.
• W3204309882 hasAuthorship W3204309882A5003435839 @default.
• W3204309882 hasAuthorship W3204309882A5030085949 @default.
• W3204309882 hasAuthorship W3204309882A5034378478 @default.
• W3204309882 hasAuthorship W3204309882A5034971594 @default.
• W3204309882 hasAuthorship W3204309882A5044929823 @default.
• W3204309882 hasAuthorship W3204309882A5060027275 @default.
• W3204309882 hasAuthorship W3204309882A5062770007 @default.
• W3204309882 hasAuthorship W3204309882A5085356021 @default.
• W3204309882 hasAuthorship W3204309882A5091641049 @default.
• W3204309882 hasBestOaLocation W32043098821 @default.
• W3204309882 hasConcept C104317684 @default.
• W3204309882 hasConcept C127716648 @default.
• W3204309882 hasConcept C142724271 @default.
• W3204309882 hasConcept C143589142 @default.
• W3204309882 hasConcept C1491633281 @default.
• W3204309882 hasConcept C153911025 @default.
• W3204309882 hasConcept C180754005 @default.
• W3204309882 hasConcept C190283241 @default.
• W3204309882 hasConcept C203522944 @default.
• W3204309882 hasConcept C2776773979 @default.
• W3204309882 hasConcept C2778980267 @default.
• W3204309882 hasConcept C2779422105 @default.
• W3204309882 hasConcept C29537977 @default.
• W3204309882 hasConcept C501734568 @default.
• W3204309882 hasConcept C502942594 @default.
• W3204309882 hasConcept C53227056 @default.
• W3204309882 hasConcept C54355233 @default.
• W3204309882 hasConcept C553184892 @default.
• W3204309882 hasConcept C62478195 @default.
• W3204309882 hasConcept C68838962 @default.
• W3204309882 hasConcept C71924100 @default.
• W3204309882 hasConcept C86554907 @default.
• W3204309882 hasConcept C86803240 @default.
• W3204309882 hasConcept C95444343 @default.
• W3204309882 hasConcept C98490376 @default.

• next