FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204327265> ?p ?o ?g. }

• W3204327265 endingPage "1649" @default.
• W3204327265 startingPage "1640" @default.
• W3204327265 abstract "Abstract Background Leucine-rich alpha-2 glycoprotein 1 (LRG1) is a circulating protein in the transforming growth factor-beta superfamily. We sought to study whether LRG1 might predict risk for all-cause and cause-specific mortality in individuals with type 2 diabetes. Methods 2012 outpatients with type 2 diabetes were followed for a median of 7.2 years and 188 death events were identified. Association of LRG1 with risk for mortality was assessed by multivariable Cox regression models. Results Participants with a higher concentration of LRG1 had an increased risk for all-cause mortality [HR (95% CI), 1.76 (1.03–3.01), 1.75 (1.03–2.98), and 4.37 (2.72–7.02) for quartiles 2, 3, and 4, respectively, compared to quartile 1]. The association remained significant after adjustment for known cardio-renal risk factors including estimated glomerular filtration rate and albuminuria [adjusted HR 2.76 (1.66–4.59), quartile 4 versus 1]. As a continuous variable, a 1-SD increment in LRG1 was associated with 1.34 (1.14–1.57)-fold adjusted risk for all-cause mortality. High plasma LRG1 was independently associated with mortality attributable to cardiovascular disease, infection, and renal diseases. Adding LRG1 into a clinical variable-based model improved discrimination (c statistics from 0.828 to 0.842, P = 0.006) and reclassification (net reclassification improvement 0.47, 95% CI 0.28–0.67) for prediction of 5-year all-cause mortality. Conclusion Plasma LRG1 predicts risk for all-cause mortality and mortality attributable to cardiovascular disease, infection, and renal disease independent of known cardio-renal risk factors. It may be a potential novel biomarker to improve risk stratification in individuals with type 2 diabetes." @default.
• W3204327265 created "2021-10-11" @default.
• W3204327265 creator A5007728467 @default.
• W3204327265 creator A5011330789 @default.
• W3204327265 creator A5024789842 @default.
• W3204327265 creator A5035282947 @default.
• W3204327265 creator A5036039345 @default.
• W3204327265 creator A5042035574 @default.
• W3204327265 creator A5059505001 @default.
• W3204327265 creator A5065381016 @default.
• W3204327265 creator A5066365214 @default.
• W3204327265 creator A5069600747 @default.
• W3204327265 creator A5075777538 @default.
• W3204327265 creator A5077424598 @default.
• W3204327265 date "2021-11-24" @default.
• W3204327265 modified "2023-10-18" @default.
• W3204327265 title "Association of Plasma Leucine-Rich Alpha-2 Glycoprotein 1 (LRG1) with All-Cause and Cause-Specific Mortality in Individuals with Type 2 Diabetes" @default.
• W3204327265 cites W1834237336 @default.
• W3204327265 cites W1844332144 @default.
• W3204327265 cites W1968234252 @default.
• W3204327265 cites W1971119095 @default.
• W3204327265 cites W1981045929 @default.
• W3204327265 cites W2028863735 @default.
• W3204327265 cites W2066552890 @default.
• W3204327265 cites W2081214164 @default.
• W3204327265 cites W2114598208 @default.
• W3204327265 cites W2118287673 @default.
• W3204327265 cites W2126919962 @default.
• W3204327265 cites W2143756124 @default.
• W3204327265 cites W2154556565 @default.
• W3204327265 cites W2160667490 @default.
• W3204327265 cites W2306356166 @default.
• W3204327265 cites W2513217124 @default.
• W3204327265 cites W2513674677 @default.
• W3204327265 cites W2521123529 @default.
• W3204327265 cites W2572211926 @default.
• W3204327265 cites W2593603324 @default.
• W3204327265 cites W2727072968 @default.
• W3204327265 cites W2782746707 @default.
• W3204327265 cites W2790150757 @default.
• W3204327265 cites W2889526011 @default.
• W3204327265 cites W2922147630 @default.
• W3204327265 cites W2945213774 @default.
• W3204327265 cites W2985940957 @default.
• W3204327265 cites W2996597015 @default.
• W3204327265 cites W2999081419 @default.
• W3204327265 cites W3006985533 @default.
• W3204327265 cites W3092901132 @default.
• W3204327265 cites W3103476613 @default.
• W3204327265 cites W3112320604 @default.
• W3204327265 cites W3133567730 @default.
• W3204327265 cites W3156597889 @default.
• W3204327265 doi "https://doi.org/10.1093/clinchem/hvab172" @default.
• W3204327265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34568896" @default.
• W3204327265 hasPublicationYear "2021" @default.
• W3204327265 type Work @default.
• W3204327265 sameAs 3204327265 @default.
• W3204327265 citedByCount "3" @default.
• W3204327265 countsByYear W32043272652022 @default.
• W3204327265 crossrefType "journal-article" @default.
• W3204327265 hasAuthorship W3204327265A5007728467 @default.
• W3204327265 hasAuthorship W3204327265A5011330789 @default.
• W3204327265 hasAuthorship W3204327265A5024789842 @default.
• W3204327265 hasAuthorship W3204327265A5035282947 @default.
• W3204327265 hasAuthorship W3204327265A5036039345 @default.
• W3204327265 hasAuthorship W3204327265A5042035574 @default.
• W3204327265 hasAuthorship W3204327265A5059505001 @default.
• W3204327265 hasAuthorship W3204327265A5065381016 @default.
• W3204327265 hasAuthorship W3204327265A5066365214 @default.
• W3204327265 hasAuthorship W3204327265A5069600747 @default.
• W3204327265 hasAuthorship W3204327265A5075777538 @default.
• W3204327265 hasAuthorship W3204327265A5077424598 @default.
• W3204327265 hasBestOaLocation W32043272651 @default.
• W3204327265 hasConcept C126322002 @default.
• W3204327265 hasConcept C134018914 @default.
• W3204327265 hasConcept C159641895 @default.
• W3204327265 hasConcept C179755657 @default.
• W3204327265 hasConcept C2776174234 @default.
• W3204327265 hasConcept C2777180221 @default.
• W3204327265 hasConcept C44249647 @default.
• W3204327265 hasConcept C50382708 @default.
• W3204327265 hasConcept C555293320 @default.
• W3204327265 hasConcept C68443243 @default.
• W3204327265 hasConcept C71924100 @default.
• W3204327265 hasConceptScore W3204327265C126322002 @default.
• W3204327265 hasConceptScore W3204327265C134018914 @default.
• W3204327265 hasConceptScore W3204327265C159641895 @default.
• W3204327265 hasConceptScore W3204327265C179755657 @default.
• W3204327265 hasConceptScore W3204327265C2776174234 @default.
• W3204327265 hasConceptScore W3204327265C2777180221 @default.
• W3204327265 hasConceptScore W3204327265C44249647 @default.
• W3204327265 hasConceptScore W3204327265C50382708 @default.
• W3204327265 hasConceptScore W3204327265C555293320 @default.
• W3204327265 hasConceptScore W3204327265C68443243 @default.
• W3204327265 hasConceptScore W3204327265C71924100 @default.
• W3204327265 hasIssue "12" @default.
• W3204327265 hasLocation W32043272651 @default.
• W3204327265 hasLocation W32043272652 @default.

• next