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• W3204328084 abstract "Background Heart failure is responsible for approximately 65% of deaths in patients with type 2 diabetes mellitus. However, existing therapeutics for type 2 diabetes mellitus have limited success on the prevention of diabetic cardiomyopathy. The aim of this study was to determine whether moderate elevation in D‐β‐hydroxybutyrate improves cardiac function in animals with type 2 diabetes mellitus. Methods and Results Type 2 diabetic (db/db) and their corresponding wild‐type mice were fed a control diet or a diet where carbohydrates were equicalorically replaced by D‐β‐hydroxybutyrate‐(R)‐1,3 butanediol monoester (ketone ester [KE]). After 4 weeks, echocardiography demonstrated that a KE diet improved systolic and diastolic function in db/db mice. A KE diet increased expression of mitochondrial succinyl‐CoA:3‐oxoacid‐CoA transferase and restored decreased expression of mitochondrial β‐hydroxybutyrate dehydrogenase, key enzymes in cardiac ketone metabolism. A KE diet significantly enhanced both basal and ADP‐mediated oxygen consumption in cardiac mitochondria from both wild‐type and db/db animals; however, it did not result in the increased mitochondrial respiratory control ratio. Additionally, db/db mice on a KE diet had increased resistance to oxidative and redox stress, with evidence of restoration of decreased expression of thioredoxin and glutathione peroxidase 4 and less permeability transition pore activity in mitochondria. Mitochondrial biogenesis, quality control, and elimination of dysfunctional mitochondria via mitophagy were significantly increased in cardiomyocytes from db/db mice on a KE diet. The increase in mitophagy was correlated with restoration of mitofusin 2 expression, which contributed to improved coupling between cytosolic E3 ubiquitin ligase translocation into mitochondria and microtubule‐associated protein 1 light chain 3–mediated autophagosome formation. Conclusions Moderate elevation in circulating D‐β‐hydroxybutyrate levels via KE supplementation enhances mitochondrial biogenesis, quality control, and oxygen consumption and increases resistance to oxidative/redox stress and mPTP opening, thus resulting in improvement of cardiac function in animals with type 2 diabetes mellitus." @default.
• W3204328084 created "2021-10-11" @default.
• W3204328084 creator A5004652247 @default.
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• W3204328084 creator A5060146085 @default.
• W3204328084 date "2021-10-05" @default.
• W3204328084 modified "2023-10-16" @default.
• W3204328084 title "Ketone Ester D‐β‐Hydroxybutyrate‐(R)‐1,3 Butanediol Prevents Decline in Cardiac Function in Type 2 Diabetic Mice" @default.
• W3204328084 cites W1146046970 @default.
• W3204328084 cites W1484633880 @default.
• W3204328084 cites W1486228890 @default.
• W3204328084 cites W1583905675 @default.
• W3204328084 cites W1584301804 @default.
• W3204328084 cites W1968516021 @default.
• W3204328084 cites W1968878147 @default.
• W3204328084 cites W1971299600 @default.
• W3204328084 cites W1977767269 @default.
• W3204328084 cites W1982089533 @default.
• W3204328084 cites W1983492852 @default.
• W3204328084 cites W1985962374 @default.
• W3204328084 cites W1996061153 @default.
• W3204328084 cites W1997997206 @default.
• W3204328084 cites W2002127348 @default.
• W3204328084 cites W2002269806 @default.
• W3204328084 cites W2002460545 @default.
• W3204328084 cites W2004285618 @default.
• W3204328084 cites W2007013554 @default.
• W3204328084 cites W2010511534 @default.
• W3204328084 cites W2016417634 @default.
• W3204328084 cites W2018422556 @default.
• W3204328084 cites W2023536633 @default.
• W3204328084 cites W2030153054 @default.
• W3204328084 cites W2033604750 @default.
• W3204328084 cites W2049126171 @default.
• W3204328084 cites W2050192690 @default.
• W3204328084 cites W2054042932 @default.
• W3204328084 cites W2060161793 @default.
• W3204328084 cites W2061059566 @default.
• W3204328084 cites W2066000449 @default.
• W3204328084 cites W2066487508 @default.
• W3204328084 cites W2068153705 @default.
• W3204328084 cites W2068314767 @default.
• W3204328084 cites W2070536001 @default.
• W3204328084 cites W2072535229 @default.
• W3204328084 cites W2075957528 @default.
• W3204328084 cites W2086557228 @default.
• W3204328084 cites W2101813970 @default.
• W3204328084 cites W2108326484 @default.
• W3204328084 cites W2117309102 @default.
• W3204328084 cites W2127125241 @default.
• W3204328084 cites W2128294133 @default.
• W3204328084 cites W2128606426 @default.
• W3204328084 cites W2136503478 @default.
• W3204328084 cites W2142134903 @default.
• W3204328084 cites W2146264128 @default.
• W3204328084 cites W2150959115 @default.
• W3204328084 cites W2153819921 @default.
• W3204328084 cites W2161479914 @default.
• W3204328084 cites W2164472512 @default.
• W3204328084 cites W2165832533 @default.
• W3204328084 cites W2168854431 @default.
• W3204328084 cites W2207209356 @default.
• W3204328084 cites W2253712555 @default.
• W3204328084 cites W2274126817 @default.
• W3204328084 cites W2280070220 @default.
• W3204328084 cites W2301033838 @default.
• W3204328084 cites W2316348002 @default.
• W3204328084 cites W2403029062 @default.
• W3204328084 cites W2482273978 @default.
• W3204328084 cites W2482292220 @default.
• W3204328084 cites W2512555677 @default.
• W3204328084 cites W2517910168 @default.
• W3204328084 cites W2580792129 @default.
• W3204328084 cites W2586243829 @default.
• W3204328084 cites W2604450164 @default.
• W3204328084 cites W2615179214 @default.
• W3204328084 cites W2618875162 @default.
• W3204328084 cites W2626446274 @default.
• W3204328084 cites W2743254891 @default.
• W3204328084 cites W2750998547 @default.
• W3204328084 cites W2752387796 @default.
• W3204328084 cites W2773272545 @default.
• W3204328084 cites W2775570563 @default.
• W3204328084 cites W2785914398 @default.
• W3204328084 cites W2790581874 @default.
• W3204328084 cites W2802155106 @default.
• W3204328084 cites W2803600657 @default.
• W3204328084 cites W2898518954 @default.
• W3204328084 cites W2903827094 @default.
• W3204328084 cites W2913394347 @default.
• W3204328084 cites W2914565943 @default.
• W3204328084 cites W2915285292 @default.
• W3204328084 cites W2917226475 @default.
• W3204328084 cites W2917743074 @default.
• W3204328084 cites W2935956047 @default.

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