Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204334392> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3204334392 abstract "Abstract Development of antibodies against the native structure of membrane proteins with multiple transmembrane domains is challenging because it is difficult to prepare antigens with native structures. Previously, we successfully developed a monoclonal antibody against multi-pass membrane protein TMEM180 by exosome immunization in rats. This approach yielded antibod-ies that recognized cancer-specific antigens on the exosome. In this study, we performed im-munoprecipitation using magnetic beads to identify the antigen of one of the rat antibody clones, 0614, as CD73. We then converted antibody 0614 to human chimeric antibody 0614-5 and found that the humanized antibody did not inhibit CD73 enzymatic activity. Glioblastoma (GB) was the cancer type with the highest expression of CD73 in the tumor relative to healthy tissue. An antibody–drug conjugate (ADC) of 0614-5 exerted an antitumor effect on GB cell lines according to expression of CD73. The 0614-5-ADC could be used to treat cancers with high CD73 expression. In addition, our strategy could be used to determine the antigen of any antibody produced by exosome immunization." @default.
- W3204334392 created "2021-10-11" @default.
- W3204334392 creator A5011661012 @default.
- W3204334392 creator A5013562821 @default.
- W3204334392 creator A5025524623 @default.
- W3204334392 creator A5032109806 @default.
- W3204334392 creator A5051774299 @default.
- W3204334392 creator A5054712766 @default.
- W3204334392 creator A5055887693 @default.
- W3204334392 date "2021-10-01" @default.
- W3204334392 modified "2023-09-26" @default.
- W3204334392 title "Identification of CD73 as the antigen of an antigen-unknown monoclonal antibody established by exosome immunization, and its antibody-drug conjugate exerts an antitumor effect on glioblastoma cell lines" @default.
- W3204334392 cites W1705652018 @default.
- W3204334392 cites W1948098427 @default.
- W3204334392 cites W1965356819 @default.
- W3204334392 cites W1970013864 @default.
- W3204334392 cites W1981959551 @default.
- W3204334392 cites W2078594804 @default.
- W3204334392 cites W2086556660 @default.
- W3204334392 cites W2151070736 @default.
- W3204334392 cites W2153092839 @default.
- W3204334392 cites W2165167811 @default.
- W3204334392 cites W2736730167 @default.
- W3204334392 cites W2904150985 @default.
- W3204334392 cites W2944727022 @default.
- W3204334392 cites W2946657092 @default.
- W3204334392 cites W2973779191 @default.
- W3204334392 cites W3087453109 @default.
- W3204334392 cites W3105591024 @default.
- W3204334392 cites W3166260715 @default.
- W3204334392 doi "https://doi.org/10.1101/2021.09.30.462527" @default.
- W3204334392 hasPublicationYear "2021" @default.
- W3204334392 type Work @default.
- W3204334392 sameAs 3204334392 @default.
- W3204334392 citedByCount "0" @default.
- W3204334392 crossrefType "posted-content" @default.
- W3204334392 hasAuthorship W3204334392A5011661012 @default.
- W3204334392 hasAuthorship W3204334392A5013562821 @default.
- W3204334392 hasAuthorship W3204334392A5025524623 @default.
- W3204334392 hasAuthorship W3204334392A5032109806 @default.
- W3204334392 hasAuthorship W3204334392A5051774299 @default.
- W3204334392 hasAuthorship W3204334392A5054712766 @default.
- W3204334392 hasAuthorship W3204334392A5055887693 @default.
- W3204334392 hasBestOaLocation W32043343921 @default.
- W3204334392 hasConcept C104317684 @default.
- W3204334392 hasConcept C134306372 @default.
- W3204334392 hasConcept C145059251 @default.
- W3204334392 hasConcept C147483822 @default.
- W3204334392 hasConcept C153911025 @default.
- W3204334392 hasConcept C159654299 @default.
- W3204334392 hasConcept C197336794 @default.
- W3204334392 hasConcept C203014093 @default.
- W3204334392 hasConcept C20518536 @default.
- W3204334392 hasConcept C2777325958 @default.
- W3204334392 hasConcept C2778556491 @default.
- W3204334392 hasConcept C2780801004 @default.
- W3204334392 hasConcept C2781261824 @default.
- W3204334392 hasConcept C33923547 @default.
- W3204334392 hasConcept C502942594 @default.
- W3204334392 hasConcept C542903549 @default.
- W3204334392 hasConcept C55493867 @default.
- W3204334392 hasConcept C86803240 @default.
- W3204334392 hasConceptScore W3204334392C104317684 @default.
- W3204334392 hasConceptScore W3204334392C134306372 @default.
- W3204334392 hasConceptScore W3204334392C145059251 @default.
- W3204334392 hasConceptScore W3204334392C147483822 @default.
- W3204334392 hasConceptScore W3204334392C153911025 @default.
- W3204334392 hasConceptScore W3204334392C159654299 @default.
- W3204334392 hasConceptScore W3204334392C197336794 @default.
- W3204334392 hasConceptScore W3204334392C203014093 @default.
- W3204334392 hasConceptScore W3204334392C20518536 @default.
- W3204334392 hasConceptScore W3204334392C2777325958 @default.
- W3204334392 hasConceptScore W3204334392C2778556491 @default.
- W3204334392 hasConceptScore W3204334392C2780801004 @default.
- W3204334392 hasConceptScore W3204334392C2781261824 @default.
- W3204334392 hasConceptScore W3204334392C33923547 @default.
- W3204334392 hasConceptScore W3204334392C502942594 @default.
- W3204334392 hasConceptScore W3204334392C542903549 @default.
- W3204334392 hasConceptScore W3204334392C55493867 @default.
- W3204334392 hasConceptScore W3204334392C86803240 @default.
- W3204334392 hasLocation W32043343921 @default.
- W3204334392 hasOpenAccess W3204334392 @default.
- W3204334392 hasPrimaryLocation W32043343921 @default.
- W3204334392 hasRelatedWork W131348366 @default.
- W3204334392 hasRelatedWork W1591820460 @default.
- W3204334392 hasRelatedWork W1973692620 @default.
- W3204334392 hasRelatedWork W2064089409 @default.
- W3204334392 hasRelatedWork W2365490899 @default.
- W3204334392 hasRelatedWork W2368460920 @default.
- W3204334392 hasRelatedWork W2380360044 @default.
- W3204334392 hasRelatedWork W4214888005 @default.
- W3204334392 hasRelatedWork W4286632949 @default.
- W3204334392 hasRelatedWork W2495428876 @default.
- W3204334392 isParatext "false" @default.
- W3204334392 isRetracted "false" @default.
- W3204334392 magId "3204334392" @default.
- W3204334392 workType "article" @default.