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- W3204337448 abstract "The transforming growth factor beta (TGF-β) signaling pathway plays complex role in the regulation of cell proliferation, apoptosis and differentiation in breast cancer. TGF-β activation can lead to multiple cellular responses mediating the drug resistance evolution, including the resistance to antiestrogens. Tamoxifen is the most commonly prescribed antiestrogen that functionally involved in regulation of TGF-β activity. In this review, we focus on the role of TGF-β signaling in the mechanisms of tamoxifen resistance, including its interaction with estrogen receptors alfa (ERα) pathway and breast cancer stem cells (BCSCs). We summarize the current reported data regarding TGF-β signaling components as markers of tamoxifen resistance and review current approaches to overcoming tamoxifen resistance based on studies of TGF-β signaling." @default.
- W3204337448 created "2021-10-11" @default.
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- W3204337448 creator A5088943549 @default.
- W3204337448 date "2021-12-01" @default.
- W3204337448 modified "2023-09-27" @default.
- W3204337448 title "Role of TGF-β signaling in the mechanisms of tamoxifen resistance" @default.
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- W3204337448 doi "https://doi.org/10.1016/j.cytogfr.2021.09.005" @default.
- W3204337448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34635390" @default.
- W3204337448 hasPublicationYear "2021" @default.
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