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• W3204337918 abstract "This chapter is an introduction to most critical aspects of label-free (LF) surface-enhanced Raman scattering (SERS) aimed at clinical applications, from basic definitions and general strategies to specific experimental issues, focusing on most common pitfalls and other problematic traits rather than on an overview of the state-of-the-art. The chapter is targeted at researchers already acquainted with basic principles of SERS who want to apply this technique for a direct detection of analytes in biochemically complex samples such as biofluids or cells and tissue extracts. After addressing general aspects of LF-SERS, experimental issues such as sample preprocessing, excitation wavelengths, and most common artifacts are critically discussed. Sources of variability specific to LF-SERS are presented, and key aspects of preprocessing, analysis and modeling of LF-SERS data are successively addressed. Most relevant issues about spectral interpretation specific to LF-SERS are then discussed, concluding with an overview of the perspectives of this technique, and the many challenges ahead." @default.
• W3204337918 created "2021-10-11" @default.
• W3204337918 creator A5024907450 @default.
• W3204337918 date "2022-01-01" @default.
• W3204337918 modified "2023-10-16" @default.
• W3204337918 title "Label-free surface-enhanced Raman scattering for clinical applications" @default.
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• W3204337918 doi "https://doi.org/10.1016/b978-0-12-821121-2.00001-9" @default.
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