Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204339600> ?p ?o ?g. }
- W3204339600 endingPage "121178" @default.
- W3204339600 startingPage "121178" @default.
- W3204339600 abstract "Although synthesized nanotherapeutics (NTs) are attractive for the oral treatment of colon diseases, their clinical translations are constrained by the unsatisfactory therapeutic outcomes, potential adverse effects, and high cost of mass production. Here, we report the development of tea leaf-derived natural NTs with desirable particle sizes (140.0 nm) and negative surface charge (-14.6 mV). These natural exosome-like NTs were found to contain large amounts of lipids, some functional proteins, and many bioactive small molecules. Specifically, galactose groups on the surface of NTs could mediate their specific internalization by macrophages via galactose receptor-mediated endocytosis. Moreover, these NTs were able to reduce the production of reactive oxygen species, inhibit the expression of pro-inflammatory cytokines, and increase the amount of anti-inflammatory IL-10 secreted by macrophages. Orally administered NTs could efficiently inhibit the inflammatory bowel responses, restore disrupted colonic barriers and enhance the diversity and overall abundance of gut microbiota, thereby preventing or alleviating inflammatory bowel disease and colitis-associated colon cancer. The present study brings new insights to the facile application of a versatile and robust natural nanoplatform for the prevention and treatment of colon diseases." @default.
- W3204339600 created "2021-10-11" @default.
- W3204339600 creator A5002696511 @default.
- W3204339600 creator A5015953429 @default.
- W3204339600 creator A5016005359 @default.
- W3204339600 creator A5045846019 @default.
- W3204339600 creator A5047305591 @default.
- W3204339600 creator A5049235303 @default.
- W3204339600 creator A5062739139 @default.
- W3204339600 creator A5075744596 @default.
- W3204339600 creator A5085963164 @default.
- W3204339600 creator A5090136226 @default.
- W3204339600 date "2021-12-01" @default.
- W3204339600 modified "2023-10-11" @default.
- W3204339600 title "‘Green’ nanotherapeutics from tea leaves for orally targeted prevention and alleviation of colon diseases" @default.
- W3204339600 cites W1596011791 @default.
- W3204339600 cites W1647551795 @default.
- W3204339600 cites W1914679235 @default.
- W3204339600 cites W1940692702 @default.
- W3204339600 cites W1960278762 @default.
- W3204339600 cites W1964144818 @default.
- W3204339600 cites W1977538148 @default.
- W3204339600 cites W1985304698 @default.
- W3204339600 cites W1992161743 @default.
- W3204339600 cites W1993239608 @default.
- W3204339600 cites W1994720283 @default.
- W3204339600 cites W1997432357 @default.
- W3204339600 cites W1997848360 @default.
- W3204339600 cites W2003572076 @default.
- W3204339600 cites W2005879027 @default.
- W3204339600 cites W2017560192 @default.
- W3204339600 cites W2019819611 @default.
- W3204339600 cites W2021239718 @default.
- W3204339600 cites W2032374729 @default.
- W3204339600 cites W2034082915 @default.
- W3204339600 cites W2040206306 @default.
- W3204339600 cites W2045568806 @default.
- W3204339600 cites W2069043245 @default.
- W3204339600 cites W2069348249 @default.
- W3204339600 cites W2074282254 @default.
- W3204339600 cites W2092546466 @default.
- W3204339600 cites W2103221654 @default.
- W3204339600 cites W2105251923 @default.
- W3204339600 cites W2109180151 @default.
- W3204339600 cites W2144331651 @default.
- W3204339600 cites W2145189896 @default.
- W3204339600 cites W2147790901 @default.
- W3204339600 cites W2151681782 @default.
- W3204339600 cites W2162932896 @default.
- W3204339600 cites W2221614322 @default.
- W3204339600 cites W2230933569 @default.
- W3204339600 cites W2262969239 @default.
- W3204339600 cites W2339102023 @default.
- W3204339600 cites W2340580991 @default.
- W3204339600 cites W2412922914 @default.
- W3204339600 cites W2588997555 @default.
- W3204339600 cites W2589600024 @default.
- W3204339600 cites W2592699639 @default.
- W3204339600 cites W2597887974 @default.
- W3204339600 cites W2747756365 @default.
- W3204339600 cites W2766046358 @default.
- W3204339600 cites W2766230324 @default.
- W3204339600 cites W2768468997 @default.
- W3204339600 cites W2783843471 @default.
- W3204339600 cites W2791062016 @default.
- W3204339600 cites W2791339509 @default.
- W3204339600 cites W2797311158 @default.
- W3204339600 cites W2885159921 @default.
- W3204339600 cites W2885936333 @default.
- W3204339600 cites W2904276508 @default.
- W3204339600 cites W2909495607 @default.
- W3204339600 cites W2911743482 @default.
- W3204339600 cites W2913009425 @default.
- W3204339600 cites W2944726119 @default.
- W3204339600 cites W2945207872 @default.
- W3204339600 cites W2969684055 @default.
- W3204339600 cites W3021840232 @default.
- W3204339600 cites W3023294073 @default.
- W3204339600 cites W3083784618 @default.
- W3204339600 cites W3101876276 @default.
- W3204339600 cites W3128427738 @default.
- W3204339600 cites W3168469168 @default.
- W3204339600 doi "https://doi.org/10.1016/j.biomaterials.2021.121178" @default.
- W3204339600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34656857" @default.
- W3204339600 hasPublicationYear "2021" @default.
- W3204339600 type Work @default.
- W3204339600 sameAs 3204339600 @default.
- W3204339600 citedByCount "75" @default.
- W3204339600 countsByYear W32043396002021 @default.
- W3204339600 countsByYear W32043396002022 @default.
- W3204339600 countsByYear W32043396002023 @default.
- W3204339600 crossrefType "journal-article" @default.
- W3204339600 hasAuthorship W3204339600A5002696511 @default.
- W3204339600 hasAuthorship W3204339600A5015953429 @default.
- W3204339600 hasAuthorship W3204339600A5016005359 @default.
- W3204339600 hasAuthorship W3204339600A5045846019 @default.
- W3204339600 hasAuthorship W3204339600A5047305591 @default.
- W3204339600 hasAuthorship W3204339600A5049235303 @default.