FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204346934> ?p ?o ?g. }

• W3204346934 abstract "Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles predominantly indole-3-carbinol (I3C). I3C and its major in vivo product, 3,3'-diindolylmethane (DIM), are effective cancer chemopreventive agents in pre-clinical models and show promise in clinical trials. The pharmacokinetics/pharmacodynamics of DIM have been studied in both rodents and humans and urinary DIM is a proposed biomarker of dietary intake of cruciferous vegetables. Recent clinical studies at Oregon State University show surprisingly robust metabolism of DIM in vivo with mono- and di-hydroxylation followed by conjugation with sulfate or glucuronic acid. DIM has multiple mechanisms of action, the most well-characterized is modulation of aryl hydrocarbon receptor (AHR) signaling. In rainbow trout dose-dependent cancer chemoprevention by dietary I3C is achieved when given prior to or concurrent with aflatoxin B1, polycyclic aromatic hydrocarbons, nitrosamines or direct acting carcinogens such as N-methyl-N'-nitro-nitrosoguanidine. Feeding pregnant mice I3C inhibits transplacental carcinogenesis. In humans much of the focus has been on chemoprevention of breast and prostate cancer. Alteration of cytochrome P450-dependent estrogen metabolism is hypothesized to be an important driver of DIM-dependent breast cancer prevention. The few studies done to date comparing glucobrassicin-rich crucifers such as Brussels sprouts with I3C/DIM supplements have shown the greater impact of the latter is due to dose. Daily ingestion of kg quantities of Brussels sprouts is required to produce in vivo levels of DIM achievable by supplementation. In clinical trials these supplement doses have elicited few if any adverse effects. Sulforaphane from glucoraphanin can act synergistically with glucobrassicin-derived DIM and this may lead to opportunities for combinatorial approaches (supplement and food-based) in the clinic." @default.
• W3204346934 created "2021-10-11" @default.
• W3204346934 creator A5086708085 @default.
• W3204346934 date "2021-10-01" @default.
• W3204346934 modified "2023-10-14" @default.
• W3204346934 title "Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane" @default.
• W3204346934 cites W1505049379 @default.
• W3204346934 cites W1549617475 @default.
• W3204346934 cites W1665140791 @default.
• W3204346934 cites W1838766486 @default.
• W3204346934 cites W1887681162 @default.
• W3204346934 cites W1897235138 @default.
• W3204346934 cites W1948740966 @default.
• W3204346934 cites W1951528568 @default.
• W3204346934 cites W1963796379 @default.
• W3204346934 cites W1968269032 @default.
• W3204346934 cites W1974546331 @default.
• W3204346934 cites W1975773180 @default.
• W3204346934 cites W1980439402 @default.
• W3204346934 cites W1980537841 @default.
• W3204346934 cites W1980722224 @default.
• W3204346934 cites W1986994410 @default.
• W3204346934 cites W1989075112 @default.
• W3204346934 cites W1995534947 @default.
• W3204346934 cites W2003178804 @default.
• W3204346934 cites W2004654818 @default.
• W3204346934 cites W2006128340 @default.
• W3204346934 cites W2007278586 @default.
• W3204346934 cites W2014580896 @default.
• W3204346934 cites W2017022701 @default.
• W3204346934 cites W2018159164 @default.
• W3204346934 cites W2020909568 @default.
• W3204346934 cites W2022297073 @default.
• W3204346934 cites W2023437169 @default.
• W3204346934 cites W2024530063 @default.
• W3204346934 cites W2026217498 @default.
• W3204346934 cites W2028204224 @default.
• W3204346934 cites W2030703336 @default.
• W3204346934 cites W2031400039 @default.
• W3204346934 cites W2031755130 @default.
• W3204346934 cites W2032131631 @default.
• W3204346934 cites W2035709997 @default.
• W3204346934 cites W2037204540 @default.
• W3204346934 cites W2037482981 @default.
• W3204346934 cites W2043620261 @default.
• W3204346934 cites W2045909643 @default.
• W3204346934 cites W2048608089 @default.
• W3204346934 cites W2051060840 @default.
• W3204346934 cites W2052528439 @default.
• W3204346934 cites W2055303609 @default.
• W3204346934 cites W2056708782 @default.
• W3204346934 cites W2058450395 @default.
• W3204346934 cites W2058673968 @default.
• W3204346934 cites W2063688776 @default.
• W3204346934 cites W2064996267 @default.
• W3204346934 cites W2065050615 @default.
• W3204346934 cites W2065840609 @default.
• W3204346934 cites W2068390361 @default.
• W3204346934 cites W2071458938 @default.
• W3204346934 cites W2080056602 @default.
• W3204346934 cites W2084311588 @default.
• W3204346934 cites W2085747509 @default.
• W3204346934 cites W2087102857 @default.
• W3204346934 cites W2088537133 @default.
• W3204346934 cites W2089001391 @default.
• W3204346934 cites W2091822207 @default.
• W3204346934 cites W2092544415 @default.
• W3204346934 cites W2093284719 @default.
• W3204346934 cites W2095385830 @default.
• W3204346934 cites W2097056458 @default.
• W3204346934 cites W2097264882 @default.
• W3204346934 cites W2097796945 @default.
• W3204346934 cites W2100269181 @default.
• W3204346934 cites W2103158155 @default.
• W3204346934 cites W2105353478 @default.
• W3204346934 cites W2105995625 @default.
• W3204346934 cites W2106840357 @default.
• W3204346934 cites W2108150108 @default.
• W3204346934 cites W2112074828 @default.
• W3204346934 cites W2117958397 @default.
• W3204346934 cites W2120566444 @default.
• W3204346934 cites W2132533511 @default.
• W3204346934 cites W2133764746 @default.
• W3204346934 cites W2136601392 @default.
• W3204346934 cites W2136633018 @default.
• W3204346934 cites W2137265332 @default.
• W3204346934 cites W2138684961 @default.
• W3204346934 cites W2138821763 @default.
• W3204346934 cites W2141304385 @default.
• W3204346934 cites W2141730376 @default.
• W3204346934 cites W2143002405 @default.
• W3204346934 cites W2144352887 @default.
• W3204346934 cites W2144720830 @default.
• W3204346934 cites W2150003441 @default.
• W3204346934 cites W2151683706 @default.
• W3204346934 cites W2152608655 @default.
• W3204346934 cites W2154395013 @default.
• W3204346934 cites W2155201524 @default.
• W3204346934 cites W2155649041 @default.
• W3204346934 cites W2157501227 @default.

• next