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- W3204352735 endingPage "43" @default.
- W3204352735 startingPage "43" @default.
- W3204352735 abstract "The protective function and transparency provided by the corneal epithelium are dependent on and maintained by the regenerative capacity of limbal epithelial stem cells (LESCs). These LESCs are supported by the limbal niche, a specialized microenvironment consisting of cellular and non-cellular components. Disruption of the limbal niche, primarily from injuries or inflammatory processes, can negatively impact the regenerative ability of LESCs. Limbal stem cell deficiency (LSCD) directly hampers the regenerative ability of the corneal epithelium and allows the conjunctival epithelium to invade the cornea, which results in severe visual impairment. Treatment involves restoring the LESC population and functionality; however, few clinically practiced therapies currently exist. This review outlines the current understanding of the limbal niche, its pathology and the emerging approaches targeted at restoring the limbal niche. Most emerging approaches are in developmental phases but show promise for treating LSCD and accelerating corneal regeneration. Specifically, we examine cell-based therapies, bio-active extracellular matrices and soluble factor therapies in considerable depth." @default.
- W3204352735 created "2021-10-11" @default.
- W3204352735 creator A5021638897 @default.
- W3204352735 creator A5034238246 @default.
- W3204352735 creator A5041087043 @default.
- W3204352735 creator A5042537628 @default.
- W3204352735 creator A5055332596 @default.
- W3204352735 creator A5059005932 @default.
- W3204352735 creator A5061203865 @default.
- W3204352735 creator A5074718723 @default.
- W3204352735 date "2021-09-22" @default.
- W3204352735 modified "2023-10-01" @default.
- W3204352735 title "The Limbal Niche and Regenerative Strategies" @default.
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