FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204352997> ?p ?o ?g. }

• W3204352997 endingPage "2050" @default.
• W3204352997 startingPage "2044" @default.
• W3204352997 abstract "Ocular chemical injuries (OCIs) commonly cause ocular damage and visual loss and treatment uses topical therapies to facilitate healing and limit complications. However, the impact of chemical injury on corneal barrier function and treatment penetration is unknown. Therefore, the aim of this study was to determine the effect of OCI on drug penetration and absorption. Porcine corneal explants were used to assess histological damage, electrical resistance, and the trans-corneal penetration/corneal adsorption of reference compounds (sodium fluorescein and rhodamine B) and dexamethasone. Corneal explants were injured with either 1 M sulfuric acid, or 1 M sodium hydroxide. Dexamethasone penetration was measured using high-performance liquid chromatography (HPLC) and that of fluorescein and rhodamine using fluorescence. Dexamethasone corneal adsorption was measured using enzyme-linked immunoabsorbant assay (ELISA). Both acid and alkaline injuries reduced trans-corneal electrical resistance. NaOH injury increased hydrophilic fluorescein penetration (NaOH 8.59 ± 1.50E-05 cm.min-1 vs. Hanks' Balanced Salt Solution (HBSS) 1.64 ± 1.01E-06 cm.min-1) with little impact on hydrophobic rhodamine B (1 M NaOH 6.55 ± 2.45E-04 cm.min-1 vs. HBSS 4.60 ± 0.972E-04 cm.min-1) and dexamethasone penetration (1 M NaOH 3.00 ± 0.853E-04 cm.min-1 vs. HBSS 2.69 ± 0.439E-04 cm.min-1). By contrast, H2SO4 decreased trans-corneal penetration of hydrophilic fluorescein (H2SO4 1.16 ± 14.2E-07 cm.min-1) and of hydrophobic dexamethasone (H2SO4 1.88 ± 0.646E-04 cm.min-1) and rhodamine B (H2SO4 4.60 ± 1.42E-05 cm.min-1). Acid and alkaline OCI differentially disrupted the corneal epithelial barrier function. Acid injury reduced penetration of hydrophobic dexamethasone and rhodamine B as well as hydrophilic fluorescein, which may translate clinically into reduced drug penetration after OCI, while alkaline injury increased fluorescein penetration, with minimal effect on dexamethasone and rhodamine B penetration." @default.
• W3204352997 created "2021-10-11" @default.
• W3204352997 creator A5024646408 @default.
• W3204352997 creator A5029524594 @default.
• W3204352997 creator A5032095290 @default.
• W3204352997 creator A5056904924 @default.
• W3204352997 creator A5079548676 @default.
• W3204352997 date "2021-01-01" @default.
• W3204352997 modified "2023-10-18" @default.
• W3204352997 title "Determining the effect of ocular chemical injuries on topical drug delivery" @default.
• W3204352997 cites W1991135510 @default.
• W3204352997 cites W1993475032 @default.
• W3204352997 cites W2003092321 @default.
• W3204352997 cites W2004920043 @default.
• W3204352997 cites W2009670667 @default.
• W3204352997 cites W2017843836 @default.
• W3204352997 cites W2038172856 @default.
• W3204352997 cites W2041007227 @default.
• W3204352997 cites W2061664688 @default.
• W3204352997 cites W2093259035 @default.
• W3204352997 cites W2126781206 @default.
• W3204352997 cites W2174871341 @default.
• W3204352997 cites W2219984909 @default.
• W3204352997 cites W2403835930 @default.
• W3204352997 cites W2520097406 @default.
• W3204352997 cites W2605505455 @default.
• W3204352997 cites W2754652285 @default.
• W3204352997 cites W2883146272 @default.
• W3204352997 cites W2890171471 @default.
• W3204352997 cites W3042580498 @default.
• W3204352997 cites W4248107770 @default.
• W3204352997 cites W4255398663 @default.
• W3204352997 cites W4292230163 @default.
• W3204352997 cites W2740966538 @default.
• W3204352997 doi "https://doi.org/10.1080/10717544.2021.1979124" @default.
• W3204352997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8491719" @default.
• W3204352997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34595979" @default.
• W3204352997 hasPublicationYear "2021" @default.
• W3204352997 type Work @default.
• W3204352997 sameAs 3204352997 @default.
• W3204352997 citedByCount "1" @default.
• W3204352997 countsByYear W32043529972022 @default.
• W3204352997 crossrefType "journal-article" @default.
• W3204352997 hasAuthorship W3204352997A5024646408 @default.
• W3204352997 hasAuthorship W3204352997A5029524594 @default.
• W3204352997 hasAuthorship W3204352997A5032095290 @default.
• W3204352997 hasAuthorship W3204352997A5056904924 @default.
• W3204352997 hasAuthorship W3204352997A5079548676 @default.
• W3204352997 hasBestOaLocation W32043529971 @default.
• W3204352997 hasConcept C118487528 @default.
• W3204352997 hasConcept C121332964 @default.
• W3204352997 hasConcept C127413603 @default.
• W3204352997 hasConcept C134018914 @default.
• W3204352997 hasConcept C161790260 @default.
• W3204352997 hasConcept C178790620 @default.
• W3204352997 hasConcept C185592680 @default.
• W3204352997 hasConcept C2776002898 @default.
• W3204352997 hasConcept C2776882836 @default.
• W3204352997 hasConcept C2778015030 @default.
• W3204352997 hasConcept C2778562268 @default.
• W3204352997 hasConcept C2778996431 @default.
• W3204352997 hasConcept C2780401358 @default.
• W3204352997 hasConcept C42475967 @default.
• W3204352997 hasConcept C43617362 @default.
• W3204352997 hasConcept C55493867 @default.
• W3204352997 hasConcept C62520636 @default.
• W3204352997 hasConcept C65165184 @default.
• W3204352997 hasConcept C71924100 @default.
• W3204352997 hasConcept C80107235 @default.
• W3204352997 hasConcept C91881484 @default.
• W3204352997 hasConceptScore W3204352997C118487528 @default.
• W3204352997 hasConceptScore W3204352997C121332964 @default.
• W3204352997 hasConceptScore W3204352997C127413603 @default.
• W3204352997 hasConceptScore W3204352997C134018914 @default.
• W3204352997 hasConceptScore W3204352997C161790260 @default.
• W3204352997 hasConceptScore W3204352997C178790620 @default.
• W3204352997 hasConceptScore W3204352997C185592680 @default.
• W3204352997 hasConceptScore W3204352997C2776002898 @default.
• W3204352997 hasConceptScore W3204352997C2776882836 @default.
• W3204352997 hasConceptScore W3204352997C2778015030 @default.
• W3204352997 hasConceptScore W3204352997C2778562268 @default.
• W3204352997 hasConceptScore W3204352997C2778996431 @default.
• W3204352997 hasConceptScore W3204352997C2780401358 @default.
• W3204352997 hasConceptScore W3204352997C42475967 @default.
• W3204352997 hasConceptScore W3204352997C43617362 @default.
• W3204352997 hasConceptScore W3204352997C55493867 @default.
• W3204352997 hasConceptScore W3204352997C62520636 @default.
• W3204352997 hasConceptScore W3204352997C65165184 @default.
• W3204352997 hasConceptScore W3204352997C71924100 @default.
• W3204352997 hasConceptScore W3204352997C80107235 @default.
• W3204352997 hasConceptScore W3204352997C91881484 @default.
• W3204352997 hasIssue "1" @default.
• W3204352997 hasLocation W32043529971 @default.
• W3204352997 hasLocation W32043529972 @default.
• W3204352997 hasLocation W32043529973 @default.
• W3204352997 hasLocation W32043529974 @default.
• W3204352997 hasLocation W32043529975 @default.
• W3204352997 hasOpenAccess W3204352997 @default.

• next