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- W3204360161 abstract "Abstract Objective Hemispheric surgeries are an effective treatment option to control seizures for children with hemimegalencephaly (HME); however, not enough is known about their cognitive outcomes. This study aimed to delineate the cognitive and language outcomes after hemispherectomy for HME and identify the clinical characteristics associated with cognition and language. Methods Data came from the Global Pediatric Epilepsy Surgery Registry, a patient‐driven web‐based registry for epilepsy surgery. We focused on children's functional status, assessed through parent‐reports of cognitive and language skills. Parents also reported on their satisfaction with surgery, their child's quality of life, and various demographic, clinical, and surgery characteristics. Results Parents of 45 children (40% female) participated. Children were aged 2.6 (SD 6.5) months at seizure onset, 10.8 (SD 12.7) months at hemispherectomy, and 8.7 (SD 4.8) years at follow‐up, at which point 68% were seizure‐free. We found that at follow‐up, 43% had average or mildly impaired cognition, 26% could speak age appropriately, and 21% had satisfactory reading skills. A total of 55%, 43%, and 17% of children first babbled, spoke their first words, and started speaking in sentences at an age‐appropriate period, respectively. Children who had undergone a right hemisphere resection and those who were older at epilepsy onset were more likely to have better cognitive and language outcomes. Significance Children with HME have delayed language milestones and continue to require significant language and literacy support long‐term after cerebral hemispherectomy." @default.
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- W3204360161 date "2021-10-04" @default.
- W3204360161 modified "2023-10-04" @default.
- W3204360161 title "Functional cognitive and language outcomes after cerebral hemispherectomy for hemimegalencephaly" @default.
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- W3204360161 doi "https://doi.org/10.1111/epi.17088" @default.
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