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• W3204363596 abstract "Abstract Recent progress in quantitative susceptibility mapping (QSM) has enabled the accurate delineation of submillimeter scale subcortical brain structures in humans. The simultaneous visualization of cortical, subcortical, and white matter structure remains, however, challenging, utilizing QSM data solely. Here we present TQ-SILiCON, a fusion method that enhances the contrast of cortical and subcortical structures and provides an excellent white matter delineation by combining QSM and conventional T1-weighted (T1w) images. In this study, we first applied QSM in the macaque monkey to map iron-rich subcortical structures. Implementing the same QSM acquisition and analysis methods allowed a similar accurate delineation of subcortical structures in humans. However, the QSM contrast of white and cortical gray matter was not sufficient for an appropriate segmentation. Applying automatic brain tissue segmentation to TQ-SILiCON images of the macaque improved the classification of subcortical brain structures as compared to the single T1 contrast by maintaining a good white to cortical gray matter contrast. Furthermore, we validated our dual-contrast fusion approach in humans and similarly demonstrated improvements in automated segmentation of cortical and subcortical structures. We believe the proposed contrast will facilitate translational studies in nonhuman primates to investigate the pathophysiology of neurodegenerative diseases that affect subcortical structures such as the basal ganglia in humans. Highlights The subcortical gray matter areas of macaque monkeys are reliably mapped by QSM, much as they are in humans. Combining T1w and QSM images improves the visualization and segmentation of white matter, cortical and subcortical structures in the macaque monkey. The proposed dual contrast TQ-SILiCON provides a similar image quality also in humans. TQ-SILiCON facilitates comparative and translational neuroscience studies investigating subcortical structures." @default.
• W3204363596 created "2021-10-11" @default.
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• W3204363596 date "2021-10-06" @default.
• W3204363596 modified "2023-10-16" @default.
• W3204363596 title "Fusion of quantitative susceptibility maps and T1-weighted images improve brain tissue contrast in primates" @default.
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• W3204363596 doi "https://doi.org/10.1101/2021.10.05.462876" @default.
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