Matches in SemOpenAlex for { <https://semopenalex.org/work/W320436660> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W320436660 abstract "Abstract : The virulence of Bacillus anthracis has been attributed to a tripartite toxin composed of three proteins designated protective antigen (PA), lethal factor (LF), and edema factor (EF). The effects of the toxin components on human PMN phagocytosis and oxidative metabolism, as measured by chemiluminescence (CL), were studied in vitro. Initially, it was determined that the avirulent Sterne strain of B. anthracis (radiation killed) required opsonization with either serum complement or antibodies against Sterne cell wall in order to be phagocytized. Phagocytosis of the opsonized Sterne cells was not affected by the individual anthrax toxin components. However, a combination of PA and EF inhibited Sterne cell phagocytosis and blocked both particulate and soluble induced PMN CL. These PMN effects were reversible upon removal of the toxin components. The PA and EF combination also increased intracellular cAMP levels. These studies suggest that two of the protein components of anthrax toxin, EF and PA, increase host susceptibility to infection by suppressing PMN function and impairing host resistance." @default.
- W320436660 created "2016-06-24" @default.
- W320436660 creator A5023522929 @default.
- W320436660 creator A5024911430 @default.
- W320436660 creator A5037389073 @default.
- W320436660 creator A5065816212 @default.
- W320436660 creator A5065521461 @default.
- W320436660 date "1984-06-13" @default.
- W320436660 modified "2023-09-27" @default.
- W320436660 title "The Effects of Anthrax Toxin Components on Human Neutrophils Infection and Immunity" @default.
- W320436660 cites W116132698 @default.
- W320436660 cites W1547153486 @default.
- W320436660 cites W1756379711 @default.
- W320436660 cites W1928296978 @default.
- W320436660 cites W1974917488 @default.
- W320436660 cites W2049338606 @default.
- W320436660 cites W2115588990 @default.
- W320436660 cites W2139077407 @default.
- W320436660 cites W2145086094 @default.
- W320436660 cites W2167931286 @default.
- W320436660 cites W2312810304 @default.
- W320436660 doi "https://doi.org/10.21236/ada144757" @default.
- W320436660 hasPublicationYear "1984" @default.
- W320436660 type Work @default.
- W320436660 sameAs 320436660 @default.
- W320436660 citedByCount "0" @default.
- W320436660 crossrefType "report" @default.
- W320436660 hasAuthorship W320436660A5023522929 @default.
- W320436660 hasAuthorship W320436660A5024911430 @default.
- W320436660 hasAuthorship W320436660A5037389073 @default.
- W320436660 hasAuthorship W320436660A5065521461 @default.
- W320436660 hasAuthorship W320436660A5065816212 @default.
- W320436660 hasConcept C104317684 @default.
- W320436660 hasConcept C123894998 @default.
- W320436660 hasConcept C160448771 @default.
- W320436660 hasConcept C168507396 @default.
- W320436660 hasConcept C185592680 @default.
- W320436660 hasConcept C202751555 @default.
- W320436660 hasConcept C2777367657 @default.
- W320436660 hasConcept C2780239966 @default.
- W320436660 hasConcept C2781090273 @default.
- W320436660 hasConcept C40767141 @default.
- W320436660 hasConcept C41810244 @default.
- W320436660 hasConcept C523546767 @default.
- W320436660 hasConcept C54355233 @default.
- W320436660 hasConcept C55493867 @default.
- W320436660 hasConcept C60987743 @default.
- W320436660 hasConcept C86803240 @default.
- W320436660 hasConcept C89372155 @default.
- W320436660 hasConcept C89423630 @default.
- W320436660 hasConceptScore W320436660C104317684 @default.
- W320436660 hasConceptScore W320436660C123894998 @default.
- W320436660 hasConceptScore W320436660C160448771 @default.
- W320436660 hasConceptScore W320436660C168507396 @default.
- W320436660 hasConceptScore W320436660C185592680 @default.
- W320436660 hasConceptScore W320436660C202751555 @default.
- W320436660 hasConceptScore W320436660C2777367657 @default.
- W320436660 hasConceptScore W320436660C2780239966 @default.
- W320436660 hasConceptScore W320436660C2781090273 @default.
- W320436660 hasConceptScore W320436660C40767141 @default.
- W320436660 hasConceptScore W320436660C41810244 @default.
- W320436660 hasConceptScore W320436660C523546767 @default.
- W320436660 hasConceptScore W320436660C54355233 @default.
- W320436660 hasConceptScore W320436660C55493867 @default.
- W320436660 hasConceptScore W320436660C60987743 @default.
- W320436660 hasConceptScore W320436660C86803240 @default.
- W320436660 hasConceptScore W320436660C89372155 @default.
- W320436660 hasConceptScore W320436660C89423630 @default.
- W320436660 hasLocation W3204366601 @default.
- W320436660 hasOpenAccess W320436660 @default.
- W320436660 hasPrimaryLocation W3204366601 @default.
- W320436660 hasRelatedWork W1592344333 @default.
- W320436660 hasRelatedWork W1596640243 @default.
- W320436660 hasRelatedWork W1610022685 @default.
- W320436660 hasRelatedWork W1783815881 @default.
- W320436660 hasRelatedWork W1828020944 @default.
- W320436660 hasRelatedWork W1965562708 @default.
- W320436660 hasRelatedWork W1974917488 @default.
- W320436660 hasRelatedWork W1995728232 @default.
- W320436660 hasRelatedWork W1995910871 @default.
- W320436660 hasRelatedWork W2004673387 @default.
- W320436660 hasRelatedWork W2055184363 @default.
- W320436660 hasRelatedWork W2083670089 @default.
- W320436660 hasRelatedWork W2101355256 @default.
- W320436660 hasRelatedWork W2108346251 @default.
- W320436660 hasRelatedWork W2115153552 @default.
- W320436660 hasRelatedWork W2115711765 @default.
- W320436660 hasRelatedWork W2144193594 @default.
- W320436660 hasRelatedWork W2167872871 @default.
- W320436660 hasRelatedWork W2185019841 @default.
- W320436660 hasRelatedWork W2405714135 @default.
- W320436660 isParatext "false" @default.
- W320436660 isRetracted "false" @default.
- W320436660 magId "320436660" @default.
- W320436660 workType "report" @default.