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- W3204367193 abstract "Although APOE ε4 carriers are at substantially higher risk of developing Alzheimer’s disease than noncarriers1, controversial evidence suggests that APOE ε4 might confer some advantages, explaining the survival of this gene (antagonistic pleiotropy)2,3. In a population-based cohort born in one week in 1946 (assessed aged 69–71 years), we assessed differential effects of APOE ε4 and β-amyloid pathology (quantified using 18F-Florbetapir-PET) on visual working memory (object–location binding). In 398 cognitively normal participants, APOE ε4 and β-amyloid had opposing effects on object identification, predicting better and poorer recall, respectively. ε4 carriers also recalled locations more precisely, with a greater advantage at higher β-amyloid burden. These results provide evidence of superior visual working memory in ε4 carriers, showing that some benefits of this genotype are demonstrable in older age, even in the preclinical stages of Alzheimer’s disease. In a sample of about 400 cognitively normal older adults, APOE ε4 genotype and β-amyloid pathology predicted better and poorer visual working memory, respectively, suggesting some benefits of ε4 in older age, even in the preclinical stages of Alzheimer’s disease." @default.
- W3204367193 created "2021-10-11" @default.
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- W3204367193 date "2021-10-07" @default.
- W3204367193 modified "2023-10-18" @default.
- W3204367193 title "Dissociable effects of APOE ε4 and β-amyloid pathology on visual working memory" @default.
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- W3204367193 doi "https://doi.org/10.1038/s43587-021-00117-4" @default.
- W3204367193 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7612005" @default.
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- W3204367193 hasPublicationYear "2021" @default.
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