FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204369339> ?p ?o ?g. }

• W3204369339 abstract "Background: Cancer-associated fibroblasts (CAFs) are the most prominent cellular components in gastric cancer (GC) stroma that contribute to GC progression, treatment resistance, and immunosuppression. This study aimed at exploring stromal CAF-related factors and developing a CAF-related classifier for predicting prognosis and therapeutic effects in GC. Methods: We downloaded mRNA expression and clinical information of 431 GC samples from Gene Expression Omnibus (GEO) and 330 GC samples from The Cancer Genome Atlas (TCGA) databases. CAF infiltrations were quantified by the estimate the proportion of immune and cancer cells (EPIC) method, and stromal scores were calculated via the Estimation of STromal and Immune cells in MAlignant Tumors using Expression data (ESTIMATE) algorithm. Stromal CAF-related genes were identified by weighted gene co-expression network analysis (WGCNA). A CAF risk signature was then developed using the univariate and least absolute shrinkage and selection operator method (LASSO) Cox regression model. We applied the Spearman test to determine the correlation among CAF risk score, CAF markers, and CAF infiltrations (estimated via EPIC, xCell, microenvironment cell populations-counter (MCP-counter), and Tumor Immune Dysfunction and Exclusion (TIDE) algorithms). The TIDE algorithm was further used to assess immunotherapy response. Gene set enrichment analysis (GSEA) was applied to clarify the molecular mechanisms. Results: The 4-gene (COL8A1, SPOCK1, AEBP1, and TIMP2) prognostic CAF model was constructed. GC patients were classified into high– and low–CAF-risk groups in accordance with their median CAF risk score, and patients in the high–CAF-risk group had significant worse prognosis. Spearman correlation analyses revealed the CAF risk score was strongly and positively correlated with stromal and CAF infiltrations, and the four model genes also exhibited positive correlations with CAF markers. Furthermore, TIDE analysis revealed high–CAF-risk patients were less likely to respond to immunotherapy. GSEA revealed that epithelial–mesenchymal transition (EMT), TGF-β signaling, hypoxia, and angiogenesis gene sets were significantly enriched in high–CAF-risk group patients. Conclusion: The present four-gene prognostic CAF signature was not only reliable for predicting prognosis but also competent to estimate clinical immunotherapy response for GC patients, which might provide significant clinical implications for guiding tailored anti-CAF therapy in combination with immunotherapy for GC patients." @default.
• W3204369339 created "2021-10-11" @default.
• W3204369339 creator A5006822602 @default.
• W3204369339 creator A5046067749 @default.
• W3204369339 creator A5059614356 @default.
• W3204369339 creator A5066221170 @default.
• W3204369339 creator A5081203128 @default.
• W3204369339 date "2021-10-08" @default.
• W3204369339 modified "2023-10-12" @default.
• W3204369339 title "Weighted Gene Co-expression Network Analysis Identifies a Cancer-Associated Fibroblast Signature for Predicting Prognosis and Therapeutic Responses in Gastric Cancer" @default.
• W3204369339 cites W1224756471 @default.
• W3204369339 cites W1736125567 @default.
• W3204369339 cites W1966116114 @default.
• W3204369339 cites W1966327575 @default.
• W3204369339 cites W1970171858 @default.
• W3204369339 cites W1979039417 @default.
• W3204369339 cites W1981197649 @default.
• W3204369339 cites W1983575915 @default.
• W3204369339 cites W2012034410 @default.
• W3204369339 cites W2012516785 @default.
• W3204369339 cites W2015616022 @default.
• W3204369339 cites W2018663224 @default.
• W3204369339 cites W2031300004 @default.
• W3204369339 cites W2032810718 @default.
• W3204369339 cites W2033278321 @default.
• W3204369339 cites W2035618305 @default.
• W3204369339 cites W2038183997 @default.
• W3204369339 cites W2042720942 @default.
• W3204369339 cites W2047267313 @default.
• W3204369339 cites W2048253455 @default.
• W3204369339 cites W2049090200 @default.
• W3204369339 cites W2063249586 @default.
• W3204369339 cites W2063804219 @default.
• W3204369339 cites W2064693449 @default.
• W3204369339 cites W2075294566 @default.
• W3204369339 cites W2076525570 @default.
• W3204369339 cites W2085121865 @default.
• W3204369339 cites W2086834665 @default.
• W3204369339 cites W2089634097 @default.
• W3204369339 cites W2095774850 @default.
• W3204369339 cites W2101586744 @default.
• W3204369339 cites W2102944868 @default.
• W3204369339 cites W2108068107 @default.
• W3204369339 cites W2110957241 @default.
• W3204369339 cites W2130430382 @default.
• W3204369339 cites W2138601221 @default.
• W3204369339 cites W2140551998 @default.
• W3204369339 cites W2148000660 @default.
• W3204369339 cites W2153895029 @default.
• W3204369339 cites W2157076315 @default.
• W3204369339 cites W2159707944 @default.
• W3204369339 cites W2163206184 @default.
• W3204369339 cites W2166607774 @default.
• W3204369339 cites W2168631000 @default.
• W3204369339 cites W2207092954 @default.
• W3204369339 cites W2214074259 @default.
• W3204369339 cites W2222357815 @default.
• W3204369339 cites W2230320310 @default.
• W3204369339 cites W2329884926 @default.
• W3204369339 cites W2347175105 @default.
• W3204369339 cites W2483785809 @default.
• W3204369339 cites W2485073741 @default.
• W3204369339 cites W2533508881 @default.
• W3204369339 cites W2587319667 @default.
• W3204369339 cites W2600132724 @default.
• W3204369339 cites W2604329262 @default.
• W3204369339 cites W2613437609 @default.
• W3204369339 cites W2734122632 @default.
• W3204369339 cites W2748134544 @default.
• W3204369339 cites W2758430588 @default.
• W3204369339 cites W2777276783 @default.
• W3204369339 cites W2779221466 @default.
• W3204369339 cites W2790543400 @default.
• W3204369339 cites W2791420379 @default.
• W3204369339 cites W2808830287 @default.
• W3204369339 cites W2809633127 @default.
• W3204369339 cites W2885532026 @default.
• W3204369339 cites W2886498337 @default.
• W3204369339 cites W2888546921 @default.
• W3204369339 cites W2895240612 @default.
• W3204369339 cites W2896872272 @default.
• W3204369339 cites W2911949455 @default.
• W3204369339 cites W2932807328 @default.
• W3204369339 cites W2944727022 @default.
• W3204369339 cites W2948787234 @default.
• W3204369339 cites W2952001873 @default.
• W3204369339 cites W2963936065 @default.
• W3204369339 cites W2966019641 @default.
• W3204369339 cites W2972028222 @default.
• W3204369339 cites W2986971615 @default.
• W3204369339 cites W3008753767 @default.
• W3204369339 cites W3009788614 @default.
• W3204369339 cites W3015939962 @default.
• W3204369339 cites W3028304854 @default.
• W3204369339 cites W3043443700 @default.
• W3204369339 cites W3044226617 @default.
• W3204369339 cites W3082482918 @default.
• W3204369339 cites W3102447658 @default.
• W3204369339 cites W3106452839 @default.
• W3204369339 cites W3118401788 @default.

• next