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• W3204376488 endingPage "1560" @default.
• W3204376488 startingPage "1560" @default.
• W3204376488 abstract "Among the chalcogens, selenium is the key element for catalyzed H2O2 reduction. In organic synthesis, catalytic amounts of organo mono- and di-selenides are largely used in different classes of oxidations, in which H2O2 alone is poorly efficient. Biological hydroperoxide metabolism is dominated by peroxidases and thioredoxin reductases, which balance hydroperoxide challenge and contribute to redox regulation. When their selenocysteine is replaced by cysteine, the cellular antioxidant defense system is impaired. Finally, classes of organoselenides have been synthesized with the aim of mimicking the biological strategy of glutathione peroxidases, but their therapeutic application has so far been limited. Moreover, their therapeutic use may be doubted, because H2O2 is not only toxic but also serves as an important messenger. Therefore, over-optimization of H2O2 reduction may lead to unexpected disturbances of metabolic regulation. Common to all these systems is the nucleophilic attack of selenium to one oxygen of the peroxide bond promoting its disruption. In this contribution, we revisit selected examples from chemistry and biology, and, by using results from accurate quantum mechanical modelling, we provide an accurate unified picture of selenium's capacity of reducing hydroperoxides. There is clear evidence that the selenoenzymes remain superior in terms of catalytic efficiency." @default.
• W3204376488 created "2021-10-11" @default.
• W3204376488 creator A5002738664 @default.
• W3204376488 creator A5008985143 @default.
• W3204376488 date "2021-09-30" @default.
• W3204376488 modified "2023-10-18" @default.
• W3204376488 title "Selenium-Catalyzed Reduction of Hydroperoxides in Chemistry and Biology" @default.
• W3204376488 cites W1604247823 @default.
• W3204376488 cites W1798381629 @default.
• W3204376488 cites W1965694067 @default.
• W3204376488 cites W1965970801 @default.
• W3204376488 cites W1978929032 @default.
• W3204376488 cites W1980385765 @default.
• W3204376488 cites W1982855958 @default.
• W3204376488 cites W1983400539 @default.
• W3204376488 cites W1995889616 @default.
• W3204376488 cites W2001617667 @default.
• W3204376488 cites W2002350252 @default.
• W3204376488 cites W2002449018 @default.
• W3204376488 cites W2008581655 @default.
• W3204376488 cites W2011905526 @default.
• W3204376488 cites W2012922133 @default.
• W3204376488 cites W2013068412 @default.
• W3204376488 cites W2013356870 @default.
• W3204376488 cites W2017906971 @default.
• W3204376488 cites W2022794086 @default.
• W3204376488 cites W2025885285 @default.
• W3204376488 cites W2027721124 @default.
• W3204376488 cites W2036954969 @default.
• W3204376488 cites W2039079135 @default.
• W3204376488 cites W2041946801 @default.
• W3204376488 cites W2051533248 @default.
• W3204376488 cites W2054382345 @default.
• W3204376488 cites W2056840435 @default.
• W3204376488 cites W2063639336 @default.
• W3204376488 cites W2066362874 @default.
• W3204376488 cites W2067114364 @default.
• W3204376488 cites W2067962322 @default.
• W3204376488 cites W2073151846 @default.
• W3204376488 cites W2073328513 @default.
• W3204376488 cites W2079404360 @default.
• W3204376488 cites W2089258642 @default.
• W3204376488 cites W2091097441 @default.
• W3204376488 cites W2091145683 @default.
• W3204376488 cites W2099409085 @default.
• W3204376488 cites W2110994841 @default.
• W3204376488 cites W2113583384 @default.
• W3204376488 cites W2115097344 @default.
• W3204376488 cites W2117656108 @default.
• W3204376488 cites W2141253451 @default.
• W3204376488 cites W2159089908 @default.
• W3204376488 cites W2294386056 @default.
• W3204376488 cites W2313477324 @default.
• W3204376488 cites W2314921780 @default.
• W3204376488 cites W2321937694 @default.
• W3204376488 cites W2326193472 @default.
• W3204376488 cites W2331629748 @default.
• W3204376488 cites W2334964705 @default.
• W3204376488 cites W2335135183 @default.
• W3204376488 cites W2340358987 @default.
• W3204376488 cites W2342170451 @default.
• W3204376488 cites W2560308712 @default.
• W3204376488 cites W2610793629 @default.
• W3204376488 cites W2611367256 @default.
• W3204376488 cites W2612704482 @default.
• W3204376488 cites W2731436448 @default.
• W3204376488 cites W2747078308 @default.
• W3204376488 cites W2749301599 @default.
• W3204376488 cites W2766100053 @default.
• W3204376488 cites W2790496684 @default.
• W3204376488 cites W2804019108 @default.
• W3204376488 cites W2888149400 @default.
• W3204376488 cites W2913697671 @default.
• W3204376488 cites W2921125469 @default.
• W3204376488 cites W2950169704 @default.
• W3204376488 cites W3014988199 @default.
• W3204376488 cites W3015608194 @default.
• W3204376488 cites W3016385818 @default.
• W3204376488 cites W3024879904 @default.
• W3204376488 cites W3037487072 @default.
• W3204376488 cites W3044752285 @default.
• W3204376488 cites W3096910279 @default.
• W3204376488 cites W3100338984 @default.
• W3204376488 cites W3101456233 @default.
• W3204376488 cites W312187524 @default.
• W3204376488 cites W3133390181 @default.
• W3204376488 cites W3156891468 @default.
• W3204376488 cites W3160756004 @default.
• W3204376488 cites W3164774047 @default.
• W3204376488 cites W3180026098 @default.
• W3204376488 cites W4237385302 @default.
• W3204376488 cites W4240796045 @default.
• W3204376488 cites W857864705 @default.
• W3204376488 doi "https://doi.org/10.3390/antiox10101560" @default.
• W3204376488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8533274" @default.
• W3204376488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34679695" @default.
• W3204376488 hasPublicationYear "2021" @default.
• W3204376488 type Work @default.

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