FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204377174> ?p ?o ?g. }

• W3204377174 abstract "We employed mutual information (MI) analysis to detect motions affecting the mechanical resistance of the human-engineered protein Top7. The results are based on the MI analysis of pair contact correlations measured in steered molecular dynamics (SMD) trajectories and their statistical dependence on global unfolding. This study is the first application of the MI analysis to SMD forced unfolding, and we furnish specific SMD recommendations for the utility of parameters and options in the TimeScapes package. The MI analysis provided a global overview of the effect of perturbation on the stability of the protein. We also employed a more conventional trajectory analysis for a detailed description of the mechanical resistance of Top7. Specifically, we investigated 1) the hydropathy of the interactions of structural segments, 2) the H2O concentration near residues relevant for unfolding, and 3) the changing hydrogen bonding patterns and main chain dihedral angles. The results show that the application of MI in the study of protein mechanical resistance can be useful for the engineering of more resistant mutants when combined with conventional analysis. We propose a novel mutation design based on the hydropathy of residues that would stabilize the unfolding region by mimicking its more stable symmetry mate. The proposed design process does not involve the introduction of covalent crosslinks, so it has the potential to preserve the conformational space and unfolding pathway of the protein." @default.
• W3204377174 created "2021-10-11" @default.
• W3204377174 creator A5010993930 @default.
• W3204377174 creator A5087411884 @default.
• W3204377174 date "2021-09-30" @default.
• W3204377174 modified "2023-09-27" @default.
• W3204377174 title "Mechanism for the Unfolding of the TOP7 Protein in Steered Molecular Dynamics Simulations as Revealed by Mutual Information Analysis" @default.
• W3204377174 cites W1969644422 @default.
• W3204377174 cites W1975304761 @default.
• W3204377174 cites W1981588480 @default.
• W3204377174 cites W1983362126 @default.
• W3204377174 cites W1984909504 @default.
• W3204377174 cites W1991074394 @default.
• W3204377174 cites W1993689973 @default.
• W3204377174 cites W1996631886 @default.
• W3204377174 cites W2023706146 @default.
• W3204377174 cites W2029667189 @default.
• W3204377174 cites W2050410320 @default.
• W3204377174 cites W2058912578 @default.
• W3204377174 cites W2067571096 @default.
• W3204377174 cites W2075460992 @default.
• W3204377174 cites W2092832320 @default.
• W3204377174 cites W2132629607 @default.
• W3204377174 cites W2141634848 @default.
• W3204377174 cites W2149179585 @default.
• W3204377174 cites W2150981663 @default.
• W3204377174 cites W2169115417 @default.
• W3204377174 cites W2377781761 @default.
• W3204377174 cites W2521176647 @default.
• W3204377174 cites W2582251909 @default.
• W3204377174 cites W2607616078 @default.
• W3204377174 cites W2608176009 @default.
• W3204377174 cites W2738606079 @default.
• W3204377174 cites W2944017485 @default.
• W3204377174 cites W2946141597 @default.
• W3204377174 cites W3087281336 @default.
• W3204377174 doi "https://doi.org/10.3389/fmolb.2021.696609" @default.
• W3204377174 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8516001" @default.
• W3204377174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34660691" @default.
• W3204377174 hasPublicationYear "2021" @default.
• W3204377174 type Work @default.
• W3204377174 sameAs 3204377174 @default.
• W3204377174 citedByCount "1" @default.
• W3204377174 countsByYear W32043771742022 @default.
• W3204377174 crossrefType "journal-article" @default.
• W3204377174 hasAuthorship W3204377174A5010993930 @default.
• W3204377174 hasAuthorship W3204377174A5087411884 @default.
• W3204377174 hasBestOaLocation W32043771741 @default.
• W3204377174 hasConcept C112887158 @default.
• W3204377174 hasConcept C147597530 @default.
• W3204377174 hasConcept C147816474 @default.
• W3204377174 hasConcept C178790620 @default.
• W3204377174 hasConcept C181199279 @default.
• W3204377174 hasConcept C185592680 @default.
• W3204377174 hasConcept C186060115 @default.
• W3204377174 hasConcept C2775981520 @default.
• W3204377174 hasConcept C32909587 @default.
• W3204377174 hasConcept C41008148 @default.
• W3204377174 hasConcept C47701112 @default.
• W3204377174 hasConcept C55493867 @default.
• W3204377174 hasConcept C59593255 @default.
• W3204377174 hasConcept C70721500 @default.
• W3204377174 hasConcept C86803240 @default.
• W3204377174 hasConcept C89025888 @default.
• W3204377174 hasConceptScore W3204377174C112887158 @default.
• W3204377174 hasConceptScore W3204377174C147597530 @default.
• W3204377174 hasConceptScore W3204377174C147816474 @default.
• W3204377174 hasConceptScore W3204377174C178790620 @default.
• W3204377174 hasConceptScore W3204377174C181199279 @default.
• W3204377174 hasConceptScore W3204377174C185592680 @default.
• W3204377174 hasConceptScore W3204377174C186060115 @default.
• W3204377174 hasConceptScore W3204377174C2775981520 @default.
• W3204377174 hasConceptScore W3204377174C32909587 @default.
• W3204377174 hasConceptScore W3204377174C41008148 @default.
• W3204377174 hasConceptScore W3204377174C47701112 @default.
• W3204377174 hasConceptScore W3204377174C55493867 @default.
• W3204377174 hasConceptScore W3204377174C59593255 @default.
• W3204377174 hasConceptScore W3204377174C70721500 @default.
• W3204377174 hasConceptScore W3204377174C86803240 @default.
• W3204377174 hasConceptScore W3204377174C89025888 @default.
• W3204377174 hasFunder F4320332161 @default.
• W3204377174 hasLocation W32043771741 @default.
• W3204377174 hasLocation W32043771742 @default.
• W3204377174 hasLocation W32043771743 @default.
• W3204377174 hasLocation W32043771744 @default.
• W3204377174 hasOpenAccess W3204377174 @default.
• W3204377174 hasPrimaryLocation W32043771741 @default.
• W3204377174 hasRelatedWork W1598148918 @default.
• W3204377174 hasRelatedWork W1985710755 @default.
• W3204377174 hasRelatedWork W1994435755 @default.
• W3204377174 hasRelatedWork W2041094522 @default.
• W3204377174 hasRelatedWork W2054217602 @default.
• W3204377174 hasRelatedWork W2086144537 @default.
• W3204377174 hasRelatedWork W2119694628 @default.
• W3204377174 hasRelatedWork W2896056828 @default.
• W3204377174 hasRelatedWork W3005141366 @default.
• W3204377174 hasRelatedWork W3204377174 @default.
• W3204377174 hasVolume "8" @default.
• W3204377174 isParatext "false" @default.
• W3204377174 isRetracted "false" @default.

• next