Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204379864> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3204379864 endingPage "239" @default.
- W3204379864 startingPage "231" @default.
- W3204379864 abstract "Background Rocuronium's rapid onset and intermediate duration of action with intravenous administration suggests that intramuscular administration might facilitate tracheal intubation without producing prolonged paralysis. Accordingly, in infants and children, the authors measured onset at the adductor pollicis and respiratory muscles to determine the optimal dose (phase I), then gave this optimal dose to determine the optimal time for tracheal intubation (phase II). Methods The authors studied 45 unpremedicated patients aged 3 months to 5 yr. In phase I, 25 patients were anesthetized with nitrous oxide and halothane and breathed spontaneously; twitch tension and minute ventilation were measured. Rocuronium (800-2,400 micrograms/kg) was injected into the quadriceps or deltoid muscle; doses varied, using an up-down technique, the goal being to bracket the dose depressing twitch 75-90% within 5 min. In phase II, deltoid injections of the optimal dose from phase I (infants: 1,000 micrograms/kg; children: 1,800 micrograms/kg) were given to 20 patients anesthetized with 0.82-1.0% halothane. Tracheal intubation was attempted 1.5-3.0 min later; time to tracheal intubation was varied, using an up-down technique. Results In phase I, 5 of 7 patients given quadriceps injections (1,200-2,200 micrograms/kg) had slow onset of twitch and ventilatory depression. With deltoid injections (800-2,400 micrograms/kg), all patients developed complete twitch depression; median time to 50% depression of minute ventilation was 3.2 min in infants and 2.8 min in children. In phase II, intubating conditions were consistently adequate or good-excellent at 2.5 min in infants and 3.0 min in children. Initial twitch recovery was at 57 +/- 13 min (mean +/- SD) in infants and 70 +/- 23 min in children. Conclusions Deltoid injections of rocuronium, 1,000 micrograms/kg in infants and 1,800 micrograms/kg in children, rapidly permit tracheal intubation in infants and children, despite a light plane of anesthesia. Duration of action of these large doses might limit clinical utility." @default.
- W3204379864 created "2021-10-11" @default.
- W3204379864 creator A5065983424 @default.
- W3204379864 creator A5069000662 @default.
- W3204379864 creator A5069001719 @default.
- W3204379864 creator A5074961488 @default.
- W3204379864 creator A5087427828 @default.
- W3204379864 date "1996-08-01" @default.
- W3204379864 modified "2023-09-23" @default.
- W3204379864 title "Intramuscular Rocuronium in Infants and Children" @default.
- W3204379864 doi "https://doi.org/10.1097/00000542-199608000-00002" @default.
- W3204379864 hasPublicationYear "1996" @default.
- W3204379864 type Work @default.
- W3204379864 sameAs 3204379864 @default.
- W3204379864 citedByCount "33" @default.
- W3204379864 countsByYear W32043798642012 @default.
- W3204379864 countsByYear W32043798642013 @default.
- W3204379864 countsByYear W32043798642014 @default.
- W3204379864 countsByYear W32043798642015 @default.
- W3204379864 countsByYear W32043798642018 @default.
- W3204379864 countsByYear W32043798642019 @default.
- W3204379864 countsByYear W32043798642021 @default.
- W3204379864 crossrefType "journal-article" @default.
- W3204379864 hasAuthorship W3204379864A5065983424 @default.
- W3204379864 hasAuthorship W3204379864A5069000662 @default.
- W3204379864 hasAuthorship W3204379864A5069001719 @default.
- W3204379864 hasAuthorship W3204379864A5074961488 @default.
- W3204379864 hasAuthorship W3204379864A5087427828 @default.
- W3204379864 hasBestOaLocation W32043798641 @default.
- W3204379864 hasConcept C127413603 @default.
- W3204379864 hasConcept C141071460 @default.
- W3204379864 hasConcept C200457457 @default.
- W3204379864 hasConcept C2776932660 @default.
- W3204379864 hasConcept C2776988050 @default.
- W3204379864 hasConcept C2778029997 @default.
- W3204379864 hasConcept C2778716859 @default.
- W3204379864 hasConcept C2779618896 @default.
- W3204379864 hasConcept C42219234 @default.
- W3204379864 hasConcept C71924100 @default.
- W3204379864 hasConcept C78519656 @default.
- W3204379864 hasConceptScore W3204379864C127413603 @default.
- W3204379864 hasConceptScore W3204379864C141071460 @default.
- W3204379864 hasConceptScore W3204379864C200457457 @default.
- W3204379864 hasConceptScore W3204379864C2776932660 @default.
- W3204379864 hasConceptScore W3204379864C2776988050 @default.
- W3204379864 hasConceptScore W3204379864C2778029997 @default.
- W3204379864 hasConceptScore W3204379864C2778716859 @default.
- W3204379864 hasConceptScore W3204379864C2779618896 @default.
- W3204379864 hasConceptScore W3204379864C42219234 @default.
- W3204379864 hasConceptScore W3204379864C71924100 @default.
- W3204379864 hasConceptScore W3204379864C78519656 @default.
- W3204379864 hasIssue "2" @default.
- W3204379864 hasLocation W32043798641 @default.
- W3204379864 hasOpenAccess W3204379864 @default.
- W3204379864 hasPrimaryLocation W32043798641 @default.
- W3204379864 hasRelatedWork W1989674802 @default.
- W3204379864 hasRelatedWork W1992995642 @default.
- W3204379864 hasRelatedWork W1997790758 @default.
- W3204379864 hasRelatedWork W2065725339 @default.
- W3204379864 hasRelatedWork W2066570323 @default.
- W3204379864 hasRelatedWork W2127590950 @default.
- W3204379864 hasRelatedWork W2165429256 @default.
- W3204379864 hasRelatedWork W2329882681 @default.
- W3204379864 hasRelatedWork W2535613642 @default.
- W3204379864 hasRelatedWork W2920709214 @default.
- W3204379864 hasVolume "85" @default.
- W3204379864 isParatext "false" @default.
- W3204379864 isRetracted "false" @default.
- W3204379864 magId "3204379864" @default.
- W3204379864 workType "article" @default.