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- W3204381826 abstract "BACKGROUND:Tissue homeostasis represents a delicate balance between anabolic and catabolic activities manifested by the resident cells and their cytokines. Cytokines play a crucial role in periodontal tissue homeostasis and disease pathogenesis. Interleukin- 22 is a novel cytokine that has been recently highlighted owing to its biological significance in the modulation of tissue responses during inflammation. Evidence of IL-22 in epithelial immune response and in T cell mediated diseases suggests that periodontal tissue might serve as an potential cellular source. AIM OF THE STUDY: To evaluate the gingival tissue and salivary levels of IL-22 in periodontal health and disease and also to evaluate if the tissue levels correlated with the salivary levels. MATERIALS AND METHODS: Twenty patients were included in the study. The study group was segregated into health and chronic periodontitis group. Gingival tissue and saliva were collected from both the groups and the protein levels ofIL-22 was detected using ELISA. Statistical analysis was done using Mann-Whitney U test and Spearman’s correlation analysis. RESULTS: The gingival tissue and salivary levels of IL-22 in disease showed a marginal increase that was not statistically significant (p = 0.4813). There was also a weak correlation between the gingival tissue and salivary levels at (p = - 0.36). CONCLUSION: IL-22 is a unique cytokine expressed in the periodontal tissues, known to exert biphasic effects, yet warrants further investigation for a better understanding of its role in the pathophysiology of periodontal disease." @default.
- W3204381826 created "2021-10-11" @default.
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- W3204381826 date "2016-04-01" @default.
- W3204381826 modified "2023-09-26" @default.
- W3204381826 title "Analysis of Gingival Tissue and Salivary Interleukin-22 (IL-22) Levels in Periodontal Health and Disease" @default.
- W3204381826 hasPublicationYear "2016" @default.
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