FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204382760> ?p ?o ?g. }

• W3204382760 endingPage "496" @default.
• W3204382760 startingPage "488" @default.
• W3204382760 abstract "Introduction. Influence of incidental nanoparticles of industrial aerosols on occupational lung diseases development is not studied enough. As nanoparticles has properties to induce inflammation and fibrosis, it is hypothesized that they affect occupational chronic obstructive pulmonary disease (COPD) phenotype. The aim was to establish monocyte subsets, airway inflammation, clinical and functional features in occupational COPD due to aerosols containing nanoparticles exposure. Materials and methods. Study design was a single center prospective cohort observational. Subjects with occupational COPD (GOLD 2011-2021 criteria) exposed to aerosols containing nanoparticles (n=50) enrolled. Comparison group - COPD in tobacco smokers (n=50), control group - healthy people (n=50). Groups were matched by demographics and COPD duration. Nanoparticles at workplaces air were measured by inductively coupled plasma atomic emission spectrometry and by scanning electron microscopy. Of participants 26 were exposed to maximal concentrations of metal nanoparticles and 24 - of silica nanoparticles. Spirography, body pletysmography, lung diffusing capacity (DLco/Va), Doppler-ehocardiography, induced sputum cytology, COPD exacerbations assessment were done. Monocyte subsets were determined by flow cytometry. Linear regression model was used to explore relationships. Results. COPD due to aerosols containing metal nanoparticles was characterized by most severe airflow limitation, lung hyperinflation, pulmonary hypertension, most prominent decrease in DLco/Va, frequent and severe COPD exacerbations, eosinophilic inflammation. The largest proportion of «classical» CD14+CD16- monocytes subset, 96,4% (90,3%; 97,2%), high level of CCR5 expression were seen in this group. The features of COPD due to aerosols containing silica nanoparticles were substantial decrease in DLco/Va, the least airflow limitation, mild lung hyperinflation, rare COPD exacerbations, paucigranulocytic inflammation. The largest proportion of «non-classical» CD14DimCD16+ monocytes with high level of CCR2 expression revealed. Mass concentration of metal nanoparticles was associated with «classical» monocytes, (B=1,5), silica nanoparticles - with «non-classical» monocytes (B=1,4). On their turn, «classical» monocytes were associated with DLco (B=-1,6), functional residual volume (B=1,2), mean pulmonary artery pressure (B=-1,4), eosinophilic inflammation. «Non-classical» monocytes were associated with DLco (B=-1,5) and paucigranulocytic inflammation (B=1,2), p<0,015. Conclusions. Exposure of incidental nanoparticles was associated with circulated monocyte subsets, airway inflammation and occupaitonal CODP phenotype." @default.
• W3204382760 created "2021-10-11" @default.
• W3204382760 creator A5005433216 @default.
• W3204382760 creator A5016465813 @default.
• W3204382760 creator A5020738172 @default.
• W3204382760 creator A5028996291 @default.
• W3204382760 creator A5031524296 @default.
• W3204382760 creator A5037613510 @default.
• W3204382760 creator A5040500320 @default.
• W3204382760 creator A5049988483 @default.
• W3204382760 creator A5064083080 @default.
• W3204382760 creator A5086531229 @default.
• W3204382760 date "2021-09-30" @default.
• W3204382760 modified "2023-09-27" @default.
• W3204382760 title "Chronic obstructive pulmonary disease due to aerosols containing nanoparticles: inflammation and phenotype features" @default.
• W3204382760 cites W105566302 @default.
• W3204382760 cites W1414886268 @default.
• W3204382760 cites W2055418771 @default.
• W3204382760 cites W2271655598 @default.
• W3204382760 cites W2290789750 @default.
• W3204382760 cites W2334738894 @default.
• W3204382760 cites W2404827672 @default.
• W3204382760 cites W2482855087 @default.
• W3204382760 cites W2561638494 @default.
• W3204382760 cites W2619721137 @default.
• W3204382760 cites W2768516422 @default.
• W3204382760 cites W2801539942 @default.
• W3204382760 cites W2802740819 @default.
• W3204382760 cites W2807833459 @default.
• W3204382760 cites W2891635313 @default.
• W3204382760 cites W2898172039 @default.
• W3204382760 cites W2913481174 @default.
• W3204382760 cites W2967035454 @default.
• W3204382760 cites W2981067716 @default.
• W3204382760 cites W3012190357 @default.
• W3204382760 doi "https://doi.org/10.31089/1026-9428-2021-61-8-488-496" @default.
• W3204382760 hasPublicationYear "2021" @default.
• W3204382760 type Work @default.
• W3204382760 sameAs 3204382760 @default.
• W3204382760 citedByCount "1" @default.
• W3204382760 countsByYear W32043827602022 @default.
• W3204382760 crossrefType "journal-article" @default.
• W3204382760 hasAuthorship W3204382760A5005433216 @default.
• W3204382760 hasAuthorship W3204382760A5016465813 @default.
• W3204382760 hasAuthorship W3204382760A5020738172 @default.
• W3204382760 hasAuthorship W3204382760A5028996291 @default.
• W3204382760 hasAuthorship W3204382760A5031524296 @default.
• W3204382760 hasAuthorship W3204382760A5037613510 @default.
• W3204382760 hasAuthorship W3204382760A5040500320 @default.
• W3204382760 hasAuthorship W3204382760A5049988483 @default.
• W3204382760 hasAuthorship W3204382760A5064083080 @default.
• W3204382760 hasAuthorship W3204382760A5086531229 @default.
• W3204382760 hasConcept C126322002 @default.
• W3204382760 hasConcept C142724271 @default.
• W3204382760 hasConcept C16020263 @default.
• W3204382760 hasConcept C164705383 @default.
• W3204382760 hasConcept C165637977 @default.
• W3204382760 hasConcept C203014093 @default.
• W3204382760 hasConcept C2776780178 @default.
• W3204382760 hasConcept C2776914184 @default.
• W3204382760 hasConcept C2777714996 @default.
• W3204382760 hasConcept C3018587741 @default.
• W3204382760 hasConcept C71924100 @default.
• W3204382760 hasConcept C90924648 @default.
• W3204382760 hasConceptScore W3204382760C126322002 @default.
• W3204382760 hasConceptScore W3204382760C142724271 @default.
• W3204382760 hasConceptScore W3204382760C16020263 @default.
• W3204382760 hasConceptScore W3204382760C164705383 @default.
• W3204382760 hasConceptScore W3204382760C165637977 @default.
• W3204382760 hasConceptScore W3204382760C203014093 @default.
• W3204382760 hasConceptScore W3204382760C2776780178 @default.
• W3204382760 hasConceptScore W3204382760C2776914184 @default.
• W3204382760 hasConceptScore W3204382760C2777714996 @default.
• W3204382760 hasConceptScore W3204382760C3018587741 @default.
• W3204382760 hasConceptScore W3204382760C71924100 @default.
• W3204382760 hasConceptScore W3204382760C90924648 @default.
• W3204382760 hasIssue "8" @default.
• W3204382760 hasLocation W32043827601 @default.
• W3204382760 hasOpenAccess W3204382760 @default.
• W3204382760 hasPrimaryLocation W32043827601 @default.
• W3204382760 hasRelatedWork W1993807667 @default.
• W3204382760 hasRelatedWork W2146490967 @default.
• W3204382760 hasRelatedWork W2159503270 @default.
• W3204382760 hasRelatedWork W2387546825 @default.
• W3204382760 hasRelatedWork W2392085925 @default.
• W3204382760 hasRelatedWork W2520442390 @default.
• W3204382760 hasRelatedWork W2565030597 @default.
• W3204382760 hasRelatedWork W3028629946 @default.
• W3204382760 hasRelatedWork W3097101884 @default.
• W3204382760 hasRelatedWork W3215020061 @default.
• W3204382760 hasVolume "61" @default.
• W3204382760 isParatext "false" @default.
• W3204382760 isRetracted "false" @default.
• W3204382760 magId "3204382760" @default.
• W3204382760 workType "article" @default.