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- W3204384142 abstract "The treatment of textile wastewater comprising many dyes as contaminants endures an essential task for environmental remediation. In addition, combating antifungal multidrug resistance (MDR) is an intimidating task, specifically owing to the limited options of alternative drugs with multitarget drug mechanisms. Incorporating natural polymeric biomaterials for drug delivery provides desirable properties for drug molecules, effectively eradicating MDR fungal growth. The current study fabricated the bipolymeric drug delivery system using chitosan-gum arabic-coated liposome 5ID nanoparticles (CS-GA-5ID-LP-NPs). This study focused on improving the solubility and sustained release profile of 5I-1H-indole (5ID). These NPs were characterized and tested mechanically as a dye adsorbent as well as their antifungal potencies against the plant pathogen, Botrytis cinerea. CS-GA-5ID-LP-NPs showed 71.23% congo red dye removal compared to crystal violet and phenol red from water and effectively had an antifungal effect on B. cinerea at 25 μg/mL MIC concentrations. The mechanism of the inhibition of B. cinereavia CS-GA-5ID-LP-NPs was attributed to stabilized microtubule polymerization in silico and in vitro. This study opens a new avenue for designing polymeric NPs as adsorbents and antifungal agents for environmental and agriculture remediation." @default.
- W3204384142 created "2021-10-11" @default.
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- W3204384142 date "2021-10-01" @default.
- W3204384142 modified "2023-10-18" @default.
- W3204384142 title "Appraisal of Chitosan-Gum Arabic-Coated Bipolymeric Nanocarriers for Efficient Dye Removal and Eradication of the Plant Pathogen <i>Botrytis cinerea</i>" @default.
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- W3204384142 doi "https://doi.org/10.1021/acsami.1c12617" @default.
- W3204384142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34596375" @default.
- W3204384142 hasPublicationYear "2021" @default.
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