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- W3204384298 abstract "Abstract Background: Downstream of kinase (DOKs), a family of adapter proteins, are frequently depicted as pivotal components of immune regulation complexes involved in the tumor progression in a wide range of cancers. Regrettably, little is known about the expression patterns and exact roles of 7 identified DOKs in pancreatic cancer (PC). Methods : In this study, we investigated the distinct expression and biological function of DOKs in PC using multiple public databases, including ONCOMINE, GEPIA, cBioPortal, and Kaplan-Meier plotter. The correlations between DOKs and cancer immune infiltrates was investigated via TIMER. In addition, we subsequently verified those in an independent cohort. Results : The expression levels of DOKs were found to be significantly upregulated in PC, interestingly higher DOK1/3/6 expressions were correlated with shorter overall survival (OS). Moreover, DOK1/2/3/5/6 had a dramatical positive correlation with the immune infiltration of PC and programmed cell death-ligand 1 (PD-L1). Conclusion : DOK1/3/6 may function as potential prognostic biomarkers and even promising immune checkpoints for PC immunotherapy." @default.
- W3204384298 created "2021-10-11" @default.
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- W3204384298 date "2021-09-28" @default.
- W3204384298 modified "2023-09-23" @default.
- W3204384298 title "DOK1/3/6 Serve as Potential Prognostic Biomarkers and Immunotherapy Targets for Pancreatic Cancer" @default.
- W3204384298 doi "https://doi.org/10.21203/rs.3.rs-907920/v1" @default.
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