FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204385059> ?p ?o ?g. }

• W3204385059 endingPage "5819" @default.
• W3204385059 startingPage "5819" @default.
• W3204385059 abstract "In this work, we designed, developed, characterized, and investigated a new chelator and its bifunctional derivative for 89Zr labeling and PET-imaging. In a preliminary study, we synthesized two hexadentate chelators named AAZTHAS and AAZTHAG, based on the seven-membered heterocycle AMPED (6-amino-6-methylperhydro-1,4-diazepine) with the aim to increase the rigidity of the 89Zr complex by using N-methyl-N-(hydroxy)succinamide or N-methyl-N-(hydroxy)glutaramide pendant arms attached to the cyclic structure. N-methylhydroxamate groups are the donor groups chosen to efficiently coordinate 89Zr. After in vitro stability tests, we selected the chelator with longer arms, AAZTHAG, as the best complexing agent for 89Zr presenting a stability of 86.4 ± 5.5% in human serum (HS) for at least 72 h. Small animal PET/CT static scans acquired at different time points (up to 24 h) and ex vivo organ distribution studies were then carried out in healthy nude mice (n = 3) to investigate the stability and biodistribution in vivo of this new 89Zr-based complex. High stability in vivo, with low accumulation of free 89Zr in bones and kidneys, was measured. Furthermore, an activated ester functionalized version of AAZTHAG was synthesized to allow the conjugation with biomolecules such as antibodies. The bifunctional chelator was then conjugated to the human anti-HER2 monoclonal antibody Trastuzumab (Tz) as a proof of principle test of conjugation to biologically active molecules. The final 89Zr labeled compound was characterized via radio-HPLC and SDS-PAGE followed by autoradiography, and its stability in different solutions was assessed for at least 4 days." @default.
• W3204385059 created "2021-10-11" @default.
• W3204385059 creator A5000481071 @default.
• W3204385059 creator A5013274072 @default.
• W3204385059 creator A5044590055 @default.
• W3204385059 creator A5052703836 @default.
• W3204385059 creator A5059752604 @default.
• W3204385059 creator A5068315207 @default.
• W3204385059 creator A5079933914 @default.
• W3204385059 date "2021-09-25" @default.
• W3204385059 modified "2023-10-06" @default.
• W3204385059 title "A Semi Rigid Novel Hydroxamate AMPED-Based Ligand for 89Zr PET Imaging" @default.
• W3204385059 cites W1966335626 @default.
• W3204385059 cites W1971229914 @default.
• W3204385059 cites W1971355551 @default.
• W3204385059 cites W1972473444 @default.
• W3204385059 cites W1977382561 @default.
• W3204385059 cites W1979550737 @default.
• W3204385059 cites W2005091504 @default.
• W3204385059 cites W2010426662 @default.
• W3204385059 cites W2015652847 @default.
• W3204385059 cites W2039574857 @default.
• W3204385059 cites W2069422722 @default.
• W3204385059 cites W2071402361 @default.
• W3204385059 cites W2072587957 @default.
• W3204385059 cites W2123595241 @default.
• W3204385059 cites W2129922868 @default.
• W3204385059 cites W2139367713 @default.
• W3204385059 cites W2152207101 @default.
• W3204385059 cites W2156491052 @default.
• W3204385059 cites W2167590372 @default.
• W3204385059 cites W2192838961 @default.
• W3204385059 cites W2216442073 @default.
• W3204385059 cites W2261107289 @default.
• W3204385059 cites W2261465365 @default.
• W3204385059 cites W2510621441 @default.
• W3204385059 cites W2556557646 @default.
• W3204385059 cites W2563650783 @default.
• W3204385059 cites W2572351655 @default.
• W3204385059 cites W2621049738 @default.
• W3204385059 cites W2709682317 @default.
• W3204385059 cites W2799412190 @default.
• W3204385059 cites W2947934120 @default.
• W3204385059 cites W3012903956 @default.
• W3204385059 cites W3083221182 @default.
• W3204385059 cites W3121060339 @default.
• W3204385059 cites W3175201947 @default.
• W3204385059 doi "https://doi.org/10.3390/molecules26195819" @default.
• W3204385059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8512011" @default.
• W3204385059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34641362" @default.
• W3204385059 hasPublicationYear "2021" @default.
• W3204385059 type Work @default.
• W3204385059 sameAs 3204385059 @default.
• W3204385059 citedByCount "4" @default.
• W3204385059 countsByYear W32043850592022 @default.
• W3204385059 countsByYear W32043850592023 @default.
• W3204385059 crossrefType "journal-article" @default.
• W3204385059 hasAuthorship W3204385059A5000481071 @default.
• W3204385059 hasAuthorship W3204385059A5013274072 @default.
• W3204385059 hasAuthorship W3204385059A5044590055 @default.
• W3204385059 hasAuthorship W3204385059A5052703836 @default.
• W3204385059 hasAuthorship W3204385059A5059752604 @default.
• W3204385059 hasAuthorship W3204385059A5068315207 @default.
• W3204385059 hasAuthorship W3204385059A5079933914 @default.
• W3204385059 hasBestOaLocation W32043850591 @default.
• W3204385059 hasConcept C112613896 @default.
• W3204385059 hasConcept C116569031 @default.
• W3204385059 hasConcept C134306372 @default.
• W3204385059 hasConcept C150903083 @default.
• W3204385059 hasConcept C161790260 @default.
• W3204385059 hasConcept C170493617 @default.
• W3204385059 hasConcept C178790620 @default.
• W3204385059 hasConcept C185592680 @default.
• W3204385059 hasConcept C197336794 @default.
• W3204385059 hasConcept C197404232 @default.
• W3204385059 hasConcept C202751555 @default.
• W3204385059 hasConcept C207001950 @default.
• W3204385059 hasConcept C21951064 @default.
• W3204385059 hasConcept C26291073 @default.
• W3204385059 hasConcept C2777807558 @default.
• W3204385059 hasConcept C2780443040 @default.
• W3204385059 hasConcept C29331040 @default.
• W3204385059 hasConcept C33923547 @default.
• W3204385059 hasConcept C49853544 @default.
• W3204385059 hasConcept C521977710 @default.
• W3204385059 hasConcept C55493867 @default.
• W3204385059 hasConcept C71240020 @default.
• W3204385059 hasConcept C86803240 @default.
• W3204385059 hasConceptScore W3204385059C112613896 @default.
• W3204385059 hasConceptScore W3204385059C116569031 @default.
• W3204385059 hasConceptScore W3204385059C134306372 @default.
• W3204385059 hasConceptScore W3204385059C150903083 @default.
• W3204385059 hasConceptScore W3204385059C161790260 @default.
• W3204385059 hasConceptScore W3204385059C170493617 @default.
• W3204385059 hasConceptScore W3204385059C178790620 @default.
• W3204385059 hasConceptScore W3204385059C185592680 @default.
• W3204385059 hasConceptScore W3204385059C197336794 @default.
• W3204385059 hasConceptScore W3204385059C197404232 @default.

• next