FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204386560> ?p ?o ?g. }

• W3204386560 endingPage "627" @default.
• W3204386560 startingPage "615" @default.
• W3204386560 abstract "// Jessica I. Christian 1 , * , Agnieszka Pastula 2 , * , Andreas Herbst 3 , 4 , Jens Neumann 5 , Maximilian K. Marschall 1 , Andrea Ofner 3 , Heike Zierahn 1 , Marlon R. Schneider 1 , Eckhard Wolf 1 , Michael Quante 2 and Frank T. Kolligs 3 , 6 , 7 , 8 1 Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig Maximilian University of Munich, Munich 81377, Germany 2 Gastroenterologie II, Klinikum rechts der Isar, Technical University of Munich, Munich 81675, Germany 3 Department of Medicine II, Ludwig Maximilian University of Munich, Munich 81377, Germany 4 Institute of Laboratory Medicine, University Hospital, Ludwig Maximilian University of Munich, Munich 81377, Germany 5 Institute of Pathology, Ludwig Maximilian University of Munich, Munich 80337, Germany 6 German Cancer Consortium (DKTK), Heidelberg 69120, Germany 7 German Cancer Research Center (DKFZ), Heidelberg 69120, Germany 8 Department of Internal Medicine and Gastroenterology, HELIOS Klinikum Berlin-Buch, Berlin 13125, Germany * These authors contributed equally to this work Correspondence to: Jessica I. Christian, email: christian@genzentrum.lmu.de Keywords: DRO1; CCDC80; colorectal cancer; tumor microenvironment; tumor suppressor Received: July 09, 2021     Accepted: September 04, 2021     Published: April 11, 2022 Copyright: © 2022 Christian et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Tumors are composed of the tumor cells and the surrounding microenvironment. Both are closely interwoven and interact by a complex and multifaceted cross-talk which plays an integral part in tumor initiation, growth, and progression. Dro1/Ccdc80 has been shown to be a potent suppressor of colorectal cancer and ubiquitous inactivation of Dro1/Ccdc80 strongly promoted colorectal carcinogenesis in Apc Min/+ mice and in a chemically-induced colorectal cancer model. The aim of the present study was to investigate whether Dro1/Ccdc80 &#x2019;s tumor suppressive function is tumor-cell-autonomous. Expression of Dro1/Ccdc80 in cancer cells had no effect on both colon tumor development in Apc Min/+ mice and formation of xenograft tumors. In contrast, DRO1/CCDC80 loss in the microenvironment strongly increased tumor growth in xenograft models, inhibited cancer cell apoptosis, and promoted intestinal epithelial cell migration. Moreover, stromal Dro1/Ccdc80 inactivation facilitated formation of intestinal epithelial organoids. Expression analyses showed Dro1/Ccdc80 to be significantly down-regulated in murine gastric cancer associated fibroblasts, in Apc Min/+ colon tumor primary stromal cells and in microdissected stroma from human colorectal cancer compared to normal, non-tumor stroma. Our results demonstrate epithelial derived DRO1/CCDC80 to be dispensable for intestinal tissue homeostasis and identify Dro1/Ccdc80 as tumor suppressor in the tumor microenvironment." @default.
• W3204386560 created "2021-10-11" @default.
• W3204386560 creator A5003801134 @default.
• W3204386560 creator A5022731114 @default.
• W3204386560 creator A5025136768 @default.
• W3204386560 creator A5029759771 @default.
• W3204386560 creator A5040038040 @default.
• W3204386560 creator A5051468478 @default.
• W3204386560 creator A5053403372 @default.
• W3204386560 creator A5054704206 @default.
• W3204386560 creator A5069245929 @default.
• W3204386560 creator A5083728481 @default.
• W3204386560 creator A5085829166 @default.
• W3204386560 date "2022-04-11" @default.
• W3204386560 modified "2023-10-04" @default.
• W3204386560 title "Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis" @default.
• W3204386560 cites W123157904 @default.
• W3204386560 cites W1679677827 @default.
• W3204386560 cites W1965157206 @default.
• W3204386560 cites W1965369905 @default.
• W3204386560 cites W1969233135 @default.
• W3204386560 cites W1988839887 @default.
• W3204386560 cites W1989025666 @default.
• W3204386560 cites W1993645975 @default.
• W3204386560 cites W1995580093 @default.
• W3204386560 cites W1998536076 @default.
• W3204386560 cites W2000368190 @default.
• W3204386560 cites W2000999630 @default.
• W3204386560 cites W2001124116 @default.
• W3204386560 cites W2004556301 @default.
• W3204386560 cites W2011910303 @default.
• W3204386560 cites W2013496808 @default.
• W3204386560 cites W2014124238 @default.
• W3204386560 cites W2021536610 @default.
• W3204386560 cites W2049643654 @default.
• W3204386560 cites W2049820772 @default.
• W3204386560 cites W2049826528 @default.
• W3204386560 cites W2050958070 @default.
• W3204386560 cites W2058693971 @default.
• W3204386560 cites W2060415972 @default.
• W3204386560 cites W2062265555 @default.
• W3204386560 cites W2062404985 @default.
• W3204386560 cites W2062809449 @default.
• W3204386560 cites W2084769511 @default.
• W3204386560 cites W2086641174 @default.
• W3204386560 cites W2089956125 @default.
• W3204386560 cites W2092154329 @default.
• W3204386560 cites W2093463613 @default.
• W3204386560 cites W2117169879 @default.
• W3204386560 cites W2117692326 @default.
• W3204386560 cites W2130584498 @default.
• W3204386560 cites W2138188580 @default.
• W3204386560 cites W2146027304 @default.
• W3204386560 cites W2154285250 @default.
• W3204386560 cites W2165936853 @default.
• W3204386560 cites W2183666475 @default.
• W3204386560 cites W2333741020 @default.
• W3204386560 cites W2512899508 @default.
• W3204386560 cites W2520329243 @default.
• W3204386560 cites W2807926268 @default.
• W3204386560 cites W2884781698 @default.
• W3204386560 cites W2014592459 @default.
• W3204386560 doi "https://doi.org/10.18632/oncotarget.28084" @default.
• W3204386560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35422964" @default.
• W3204386560 hasPublicationYear "2022" @default.
• W3204386560 type Work @default.
• W3204386560 sameAs 3204386560 @default.
• W3204386560 citedByCount "7" @default.
• W3204386560 countsByYear W32043865602022 @default.
• W3204386560 countsByYear W32043865602023 @default.
• W3204386560 crossrefType "journal-article" @default.
• W3204386560 hasAuthorship W3204386560A5003801134 @default.
• W3204386560 hasAuthorship W3204386560A5022731114 @default.
• W3204386560 hasAuthorship W3204386560A5025136768 @default.
• W3204386560 hasAuthorship W3204386560A5029759771 @default.
• W3204386560 hasAuthorship W3204386560A5040038040 @default.
• W3204386560 hasAuthorship W3204386560A5051468478 @default.
• W3204386560 hasAuthorship W3204386560A5053403372 @default.
• W3204386560 hasAuthorship W3204386560A5054704206 @default.
• W3204386560 hasAuthorship W3204386560A5069245929 @default.
• W3204386560 hasAuthorship W3204386560A5083728481 @default.
• W3204386560 hasAuthorship W3204386560A5085829166 @default.
• W3204386560 hasBestOaLocation W32043865601 @default.
• W3204386560 hasConcept C154775046 @default.
• W3204386560 hasConcept C161191863 @default.
• W3204386560 hasConcept C166957645 @default.
• W3204386560 hasConcept C41008148 @default.
• W3204386560 hasConcept C71924100 @default.
• W3204386560 hasConcept C95457728 @default.
• W3204386560 hasConceptScore W3204386560C154775046 @default.
• W3204386560 hasConceptScore W3204386560C161191863 @default.
• W3204386560 hasConceptScore W3204386560C166957645 @default.
• W3204386560 hasConceptScore W3204386560C41008148 @default.
• W3204386560 hasConceptScore W3204386560C71924100 @default.
• W3204386560 hasConceptScore W3204386560C95457728 @default.
• W3204386560 hasIssue "1" @default.
• W3204386560 hasLocation W32043865601 @default.
• W3204386560 hasLocation W32043865602 @default.

• next