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• W3204390325 abstract "A temporal artery biopsy (TAB) is the reference standard for the diagnosis of giant cell arteritis (GCA). The necessity of performing a bilateral biopsy has continued to be debated. The primary objective of our study was to assess the rate of discordance between the pathology results in patients who had undergone bilateral temporal artery biopsy for suspected GCA. We performed a retrospective review of patients who had undergone bilateral temporal artery biopsy for the diagnosis of GCA between 2011 and 2020. The primary endpoint was the rate of discordance between specimens from patients with pathology-positive GCA. The secondary endpoints included assessments of the sensitivity of preoperative temporal artery duplex ultrasound, and the effects of specimen length and specialty of the referring provider on the diagnostic yield of the biopsy. During the study period, 310 patients had undergone bilateral temporal artery biopsy for the diagnosis of GCA. These patients were primarily women (73.9%), elderly (mean age, 70.8 years), and white (95.8%). The patients' preoperative symptoms were typically bilateral (59%) and included headache (81%), vision changes (45.2%), and temporal tenderness (32.6%). Most patients (85.2%) were receiving preoperative steroid therapy at the surgical biopsy with a mean preoperative steroid therapy duration of 15.1 days. Overall, 91 patients (29.4%) had a positive pathologic diagnosis after bilateral temporal artery biopsy. Of these patients, 11 had a positive pathology result in only a single specimen, for a discordance rate of 12.1% (Table). Preoperative temporal artery duplex ultrasound demonstrated low sensitivity (27.3%) for identifying patients with pathologically positive disease. No significant differences were between patients with pathology-positive and -negative findings in terms of the mean surgical specimen length (1.67 vs 1.64 cm; P = .67) or specialty of the referring provider (P = .73). At our institution, we found a low level of discordance between the pathology results for patients who had undergone bilateral temporal artery biopsy for the diagnosis of GCA. Preoperative temporal artery duplex ultrasound provided little value in identifying patients with biopsy-proven GCA.TableComparison of pathology results of temporal artery specimens after bilateral temporal artery biopsy for suspected GCAaPathologic resultLeftRightPositiveNegativePositive8011Negative0219GCA, Giant cell arteritis.aThe overall discordance rate was 12.1%. Open table in a new tab" @default.
• W3204390325 created "2021-10-11" @default.
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• W3204390325 date "2021-10-01" @default.
• W3204390325 modified "2023-09-27" @default.
• W3204390325 title "The Utility of the Bilateral Temporal Artery Biopsy for Diagnosis of Giant Cell Arteritis" @default.
• W3204390325 doi "https://doi.org/10.1016/j.jvs.2021.07.067" @default.
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