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- W3204402887 endingPage "1010" @default.
- W3204402887 startingPage "993" @default.
- W3204402887 abstract "Low-intensity ultrasound-triggered sonodynamic therapy (SDT) is a promising noninvasive therapeutic modality due to its strong tissue penetration ability. In recent years, with the development of nanotechnology, nanoparticle-based sonosensitizer-mediated SDT has been widely investigated. With the increasing demand for precise and personalized treatment, abundant novel sonosensitizers with imaging capabilities have been developed for determining the optimal therapeutic window, thus significantly enhancing treatment efficacy. In this review, we focus on the molecular imaging-guided SDT. The prevalent mechanisms of SDT are discussed, including ultrasonic cavitation, sonoluminescence, reactive oxygen species, and mechanical damage. In addition, we introduce the major molecular imaging techniques and the design principles based on nanoparticles to achieve efficient imaging. Furthermore, the imaging-guided SDT for the treatment of cancer, bacterial infections, and vascular diseases is summarized. The ultimate goal is to design more effective imaging-guided SDT modalities and provide novel ideas for clinical translation of SDT." @default.
- W3204402887 created "2021-10-11" @default.
- W3204402887 creator A5010516895 @default.
- W3204402887 creator A5032937271 @default.
- W3204402887 creator A5081170905 @default.
- W3204402887 creator A5085037467 @default.
- W3204402887 date "2021-10-01" @default.
- W3204402887 modified "2023-10-18" @default.
- W3204402887 title "Molecular Imaging-Guided Sonodynamic Therapy" @default.
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