FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204403576> ?p ?o ?g. }

• W3204403576 abstract "Phellodendri Chinensis Cortex (PCC) and Atractylodis Rhizoma (AR) are frequently used as herb pair to treat eczema and gout owing to their synergistic effects. Alkaloids are the major ingredients from PCC and the effect of their combination on the in vivo processing of alkaloids remains unclear. In this study, a simple and reliable UPLC-MS/MS method for simultaneous determination of six alkaloids in rat plasma was developed. This method was applied to a comparative pharmacokinetic study between PCC and PCC-AR in rats. Effect of AR on absorption of alkaloids was investigated by a single-pass intestinal perfusion study. The effect of AR on urinary excretion of alkaloids was studied. Pharmacokinetic studies showed that the values of rea under the concentration-time curve of phellodendrine, magnoflorine and palmatine were greater in the PCC-AR group than in the PCC group. The intestinal absorptive parameters absorption rate constant and effective permeability of phellodendrine and jatrorrhizine in PCC-AR groups were higher than those in the PCC group. Urinary excretion studies revealed that the excreted amount of alkaloids in the PCC-AR group was lower than that in the PCC group. The results revealed that the combination of PCC and AR improves intestinal absorption of alkaloids and reduces their urinary excretion, which enhances their systemic exposure. This study may explain the synergetic effects of PCC and AR in clinical applications." @default.
• W3204403576 created "2021-10-11" @default.
• W3204403576 creator A5005915356 @default.
• W3204403576 creator A5008606950 @default.
• W3204403576 creator A5039545940 @default.
• W3204403576 creator A5058940326 @default.
• W3204403576 creator A5073405144 @default.
• W3204403576 creator A5083093965 @default.
• W3204403576 creator A5087155240 @default.
• W3204403576 date "2021-10-21" @default.
• W3204403576 modified "2023-09-30" @default.
• W3204403576 title "Comparative pharmacokinetics, intestinal absorption and urinary excretion of six alkaloids from herb pair Phellodendri Chinensis cortex–Atractylodis Rhizoma" @default.
• W3204403576 cites W1021490511 @default.
• W3204403576 cites W1967850881 @default.
• W3204403576 cites W1968266097 @default.
• W3204403576 cites W1996274193 @default.
• W3204403576 cites W2073875274 @default.
• W3204403576 cites W2159912770 @default.
• W3204403576 cites W2272399875 @default.
• W3204403576 cites W2732066871 @default.
• W3204403576 cites W2805600500 @default.
• W3204403576 cites W2903123396 @default.
• W3204403576 cites W2905228527 @default.
• W3204403576 cites W2912115443 @default.
• W3204403576 cites W2940861225 @default.
• W3204403576 cites W2948081969 @default.
• W3204403576 cites W2991909367 @default.
• W3204403576 cites W2998602638 @default.
• W3204403576 cites W3034154936 @default.
• W3204403576 cites W3035154577 @default.
• W3204403576 cites W3083161197 @default.
• W3204403576 cites W3090268429 @default.
• W3204403576 cites W3108200375 @default.
• W3204403576 doi "https://doi.org/10.1002/bmc.5254" @default.
• W3204403576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34605575" @default.
• W3204403576 hasPublicationYear "2021" @default.
• W3204403576 type Work @default.
• W3204403576 sameAs 3204403576 @default.
• W3204403576 citedByCount "1" @default.
• W3204403576 crossrefType "journal-article" @default.
• W3204403576 hasAuthorship W3204403576A5005915356 @default.
• W3204403576 hasAuthorship W3204403576A5008606950 @default.
• W3204403576 hasAuthorship W3204403576A5039545940 @default.
• W3204403576 hasAuthorship W3204403576A5058940326 @default.
• W3204403576 hasAuthorship W3204403576A5073405144 @default.
• W3204403576 hasAuthorship W3204403576A5083093965 @default.
• W3204403576 hasAuthorship W3204403576A5087155240 @default.
• W3204403576 hasConcept C10146269 @default.
• W3204403576 hasConcept C112705442 @default.
• W3204403576 hasConcept C121332964 @default.
• W3204403576 hasConcept C125287762 @default.
• W3204403576 hasConcept C179998833 @default.
• W3204403576 hasConcept C185592680 @default.
• W3204403576 hasConcept C24890656 @default.
• W3204403576 hasConcept C2776661111 @default.
• W3204403576 hasConcept C2777667214 @default.
• W3204403576 hasConcept C2778439678 @default.
• W3204403576 hasConcept C2778746568 @default.
• W3204403576 hasConcept C2779824472 @default.
• W3204403576 hasConcept C2780116568 @default.
• W3204403576 hasConcept C2991655182 @default.
• W3204403576 hasConcept C43617362 @default.
• W3204403576 hasConcept C55493867 @default.
• W3204403576 hasConcept C556039675 @default.
• W3204403576 hasConcept C71240020 @default.
• W3204403576 hasConcept C71924100 @default.
• W3204403576 hasConcept C98274493 @default.
• W3204403576 hasConceptScore W3204403576C10146269 @default.
• W3204403576 hasConceptScore W3204403576C112705442 @default.
• W3204403576 hasConceptScore W3204403576C121332964 @default.
• W3204403576 hasConceptScore W3204403576C125287762 @default.
• W3204403576 hasConceptScore W3204403576C179998833 @default.
• W3204403576 hasConceptScore W3204403576C185592680 @default.
• W3204403576 hasConceptScore W3204403576C24890656 @default.
• W3204403576 hasConceptScore W3204403576C2776661111 @default.
• W3204403576 hasConceptScore W3204403576C2777667214 @default.
• W3204403576 hasConceptScore W3204403576C2778439678 @default.
• W3204403576 hasConceptScore W3204403576C2778746568 @default.
• W3204403576 hasConceptScore W3204403576C2779824472 @default.
• W3204403576 hasConceptScore W3204403576C2780116568 @default.
• W3204403576 hasConceptScore W3204403576C2991655182 @default.
• W3204403576 hasConceptScore W3204403576C43617362 @default.
• W3204403576 hasConceptScore W3204403576C55493867 @default.
• W3204403576 hasConceptScore W3204403576C556039675 @default.
• W3204403576 hasConceptScore W3204403576C71240020 @default.
• W3204403576 hasConceptScore W3204403576C71924100 @default.
• W3204403576 hasConceptScore W3204403576C98274493 @default.
• W3204403576 hasIssue "1" @default.
• W3204403576 hasLocation W32044035761 @default.
• W3204403576 hasLocation W32044035762 @default.
• W3204403576 hasOpenAccess W3204403576 @default.
• W3204403576 hasPrimaryLocation W32044035761 @default.
• W3204403576 hasRelatedWork W1488538445 @default.
• W3204403576 hasRelatedWork W2000193148 @default.
• W3204403576 hasRelatedWork W2049758855 @default.
• W3204403576 hasRelatedWork W2057577442 @default.
• W3204403576 hasRelatedWork W2162582941 @default.
• W3204403576 hasRelatedWork W2380199653 @default.
• W3204403576 hasRelatedWork W2388177509 @default.
• W3204403576 hasRelatedWork W2415188277 @default.

• next