Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204403898> ?p ?o ?g. }
- W3204403898 endingPage "e0258223" @default.
- W3204403898 startingPage "e0258223" @default.
- W3204403898 abstract "Background Dialysis patients have an increased risk of mortality. Recently treatment with haemodiafiltration (HDF) has been reported to reduce mortality, particularly cardiovascular mortality, compared to standard high-flux haemodialysis (HD). However, why HDF may offer a survival advantage remains to be determined. So, we conducted a pilot study to explore differences in middle-molecules, inflammation and markers of vascular disease in patients treated by HD and HDF. Methods Observational cross-sectional study measuring serum β2-microglobulin (β2M), Advanced Glycosylation End Products (AGEs) by skin autofluorescence (SAF), oxidative stress with ischaemia modified albumin ratio (IMAR) and peripheral vascular disease assessment using Ankle-Brachial Index (ABI), and arterial stiffness using Cardio-Ankle Vascular Index (CAVI). Results We studied 196 patients, mean age 69.1 ± 12.4 years, 172 (87.8%) treated by HD and 24 (12.2%) by HDF. Age, body mass index, co-morbidity and dialysis vintage were not different between HD and HDF groups. Middle molecules; β 2 M (31±9.9 vs 31.2±10 ug/mL) and SAF (2.99±0.72 vs 3.0±0.84 AU), ABI (1.06±0.05 vs 1.07±0.10) and CAVI (9.34±1.55 vs 9.35±1.23) were not different, but IMAR was higher in the HD patients (38.4±14.8 vs 31.3 ± 17.4, P = 0.035) Conclusions In this pilot observational study, we found patients treated by HDF had lower oxidative stress as measured by IMAR, with no differences in middle molecules. Lower oxidative stress would be expected to have diverse protective effects on the cardiovascular system Although we found no differences in ABI and CAVI, future studies are required to determine whether reduced oxidative stress translates into clinically relevant differences over time." @default.
- W3204403898 created "2021-10-11" @default.
- W3204403898 creator A5018414776 @default.
- W3204403898 creator A5024893578 @default.
- W3204403898 creator A5027077891 @default.
- W3204403898 creator A5045023146 @default.
- W3204403898 creator A5056527532 @default.
- W3204403898 creator A5080557810 @default.
- W3204403898 creator A5084766453 @default.
- W3204403898 creator A5088913338 @default.
- W3204403898 date "2021-10-06" @default.
- W3204403898 modified "2023-10-18" @default.
- W3204403898 title "Pilot study to investigate differences in middle molecules, oxidative stress and markers of peripheral vascular disease in patients treated by high flux haemodialysis and haemodiafiltration" @default.
- W3204403898 cites W1612511352 @default.
- W3204403898 cites W1963829731 @default.
- W3204403898 cites W1972145198 @default.
- W3204403898 cites W1972418851 @default.
- W3204403898 cites W1984542647 @default.
- W3204403898 cites W1994913549 @default.
- W3204403898 cites W2036985241 @default.
- W3204403898 cites W2050515508 @default.
- W3204403898 cites W2062853571 @default.
- W3204403898 cites W2066072274 @default.
- W3204403898 cites W2068900191 @default.
- W3204403898 cites W2070689957 @default.
- W3204403898 cites W2086528565 @default.
- W3204403898 cites W2088850537 @default.
- W3204403898 cites W2128138554 @default.
- W3204403898 cites W2136061989 @default.
- W3204403898 cites W2138657762 @default.
- W3204403898 cites W2150175482 @default.
- W3204403898 cites W2163425767 @default.
- W3204403898 cites W2172134869 @default.
- W3204403898 cites W2299791210 @default.
- W3204403898 cites W2566571331 @default.
- W3204403898 cites W2796410463 @default.
- W3204403898 cites W2799792923 @default.
- W3204403898 cites W2809649990 @default.
- W3204403898 cites W2852682743 @default.
- W3204403898 cites W2890404305 @default.
- W3204403898 doi "https://doi.org/10.1371/journal.pone.0258223" @default.
- W3204403898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8494338" @default.
- W3204403898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34614018" @default.
- W3204403898 hasPublicationYear "2021" @default.
- W3204403898 type Work @default.
- W3204403898 sameAs 3204403898 @default.
- W3204403898 citedByCount "3" @default.
- W3204403898 countsByYear W32044038982021 @default.
- W3204403898 countsByYear W32044038982022 @default.
- W3204403898 crossrefType "journal-article" @default.
- W3204403898 hasAuthorship W3204403898A5018414776 @default.
- W3204403898 hasAuthorship W3204403898A5024893578 @default.
- W3204403898 hasAuthorship W3204403898A5027077891 @default.
- W3204403898 hasAuthorship W3204403898A5045023146 @default.
- W3204403898 hasAuthorship W3204403898A5056527532 @default.
- W3204403898 hasAuthorship W3204403898A5080557810 @default.
- W3204403898 hasAuthorship W3204403898A5084766453 @default.
- W3204403898 hasAuthorship W3204403898A5088913338 @default.
- W3204403898 hasBestOaLocation W32044038981 @default.
- W3204403898 hasConcept C126322002 @default.
- W3204403898 hasConcept C141071460 @default.
- W3204403898 hasConcept C164705383 @default.
- W3204403898 hasConcept C2775850156 @default.
- W3204403898 hasConcept C2776151105 @default.
- W3204403898 hasConcept C2778063415 @default.
- W3204403898 hasConcept C2779978075 @default.
- W3204403898 hasConcept C2780221984 @default.
- W3204403898 hasConcept C71924100 @default.
- W3204403898 hasConcept C84393581 @default.
- W3204403898 hasConcept C90924648 @default.
- W3204403898 hasConceptScore W3204403898C126322002 @default.
- W3204403898 hasConceptScore W3204403898C141071460 @default.
- W3204403898 hasConceptScore W3204403898C164705383 @default.
- W3204403898 hasConceptScore W3204403898C2775850156 @default.
- W3204403898 hasConceptScore W3204403898C2776151105 @default.
- W3204403898 hasConceptScore W3204403898C2778063415 @default.
- W3204403898 hasConceptScore W3204403898C2779978075 @default.
- W3204403898 hasConceptScore W3204403898C2780221984 @default.
- W3204403898 hasConceptScore W3204403898C71924100 @default.
- W3204403898 hasConceptScore W3204403898C84393581 @default.
- W3204403898 hasConceptScore W3204403898C90924648 @default.
- W3204403898 hasIssue "10" @default.
- W3204403898 hasLocation W32044038981 @default.
- W3204403898 hasLocation W32044038982 @default.
- W3204403898 hasLocation W32044038983 @default.
- W3204403898 hasLocation W32044038984 @default.
- W3204403898 hasLocation W32044038985 @default.
- W3204403898 hasLocation W32044038986 @default.
- W3204403898 hasOpenAccess W3204403898 @default.
- W3204403898 hasPrimaryLocation W32044038981 @default.
- W3204403898 hasRelatedWork W113810927 @default.
- W3204403898 hasRelatedWork W1974548178 @default.
- W3204403898 hasRelatedWork W2068564424 @default.
- W3204403898 hasRelatedWork W2083952024 @default.
- W3204403898 hasRelatedWork W2085122642 @default.
- W3204403898 hasRelatedWork W2264708876 @default.
- W3204403898 hasRelatedWork W2331223368 @default.
- W3204403898 hasRelatedWork W2348301023 @default.