Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204406232> ?p ?o ?g. }
- W3204406232 abstract "Abstract This hypothesis proposes that increased extracellular glutamate in Amyotrophic Lateral Sclerosis (ALS) and cerebral ischemia, currently viewed as a trigger for excitotoxicity, is actually beneficial as it stimulates the utilization of glutamate as metabolic fuel. Renewed appreciation of glutamate oxidation by ischemic neurons has raised questions regarding the role of extracellular glutamate in ischemia. Is it detrimental, as suggested by excitotoxicity in early in vitro studies, or beneficial, as suggested by its oxidation in later in vivo studies? The answer may depend on the activity of N‐methyl‐D‐aspartate (NMDA) glutamate receptors. Early in vitro procedures co‐activated NMDA receptors (NMDARs) containing 2A (GluN2A) and 2B (GluN2B) subunits, an event now believed to trigger excitotoxicity; however, during in vivo ischemia D‐serine and zinc molecules are released and these ensure only GluN2B receptors are stimulated. This not only prevents excitotoxicity but also initiates signaling cascades that allow ischemic neurons to import and oxidize glutamate." @default.
- W3204406232 created "2021-10-11" @default.
- W3204406232 creator A5063035277 @default.
- W3204406232 date "2021-09-28" @default.
- W3204406232 modified "2023-10-17" @default.
- W3204406232 title "A beneficial role for elevated extracellular glutamate in Amyotrophic Lateral Sclerosis and cerebral ischemia" @default.
- W3204406232 cites W1496902741 @default.
- W3204406232 cites W1542202136 @default.
- W3204406232 cites W1553707188 @default.
- W3204406232 cites W1569903516 @default.
- W3204406232 cites W1592375995 @default.
- W3204406232 cites W1599662080 @default.
- W3204406232 cites W181688216 @default.
- W3204406232 cites W183820607 @default.
- W3204406232 cites W1873187871 @default.
- W3204406232 cites W1890775238 @default.
- W3204406232 cites W1908480989 @default.
- W3204406232 cites W1947475203 @default.
- W3204406232 cites W1965216069 @default.
- W3204406232 cites W1966165969 @default.
- W3204406232 cites W1971639674 @default.
- W3204406232 cites W1974796205 @default.
- W3204406232 cites W1974951198 @default.
- W3204406232 cites W1977642609 @default.
- W3204406232 cites W1977860033 @default.
- W3204406232 cites W1978895733 @default.
- W3204406232 cites W1979143375 @default.
- W3204406232 cites W1979385451 @default.
- W3204406232 cites W1979476115 @default.
- W3204406232 cites W1980935526 @default.
- W3204406232 cites W1981606233 @default.
- W3204406232 cites W1987265340 @default.
- W3204406232 cites W1987658639 @default.
- W3204406232 cites W1989369955 @default.
- W3204406232 cites W1990076069 @default.
- W3204406232 cites W1990459200 @default.
- W3204406232 cites W1991614275 @default.
- W3204406232 cites W1992271952 @default.
- W3204406232 cites W1994905309 @default.
- W3204406232 cites W1995630439 @default.
- W3204406232 cites W1996589674 @default.
- W3204406232 cites W1997661903 @default.
- W3204406232 cites W1998106951 @default.
- W3204406232 cites W1998519511 @default.
- W3204406232 cites W2000132885 @default.
- W3204406232 cites W2002664835 @default.
- W3204406232 cites W2003694254 @default.
- W3204406232 cites W2007124084 @default.
- W3204406232 cites W2007957574 @default.
- W3204406232 cites W2009244271 @default.
- W3204406232 cites W2010131630 @default.
- W3204406232 cites W2013874516 @default.
- W3204406232 cites W2014893821 @default.
- W3204406232 cites W2014898107 @default.
- W3204406232 cites W2016379134 @default.
- W3204406232 cites W2020916481 @default.
- W3204406232 cites W2021383894 @default.
- W3204406232 cites W2023906095 @default.
- W3204406232 cites W2026178475 @default.
- W3204406232 cites W2027318087 @default.
- W3204406232 cites W2029922642 @default.
- W3204406232 cites W2033283555 @default.
- W3204406232 cites W2033648990 @default.
- W3204406232 cites W2033704312 @default.
- W3204406232 cites W2034843832 @default.
- W3204406232 cites W2034917579 @default.
- W3204406232 cites W2037852973 @default.
- W3204406232 cites W2038330052 @default.
- W3204406232 cites W2043043281 @default.
- W3204406232 cites W2046135870 @default.
- W3204406232 cites W2048089240 @default.
- W3204406232 cites W2048764230 @default.
- W3204406232 cites W2051387942 @default.
- W3204406232 cites W2052332287 @default.
- W3204406232 cites W2054451338 @default.
- W3204406232 cites W2055601782 @default.
- W3204406232 cites W2055678857 @default.
- W3204406232 cites W2062639408 @default.
- W3204406232 cites W2066643051 @default.
- W3204406232 cites W2070178074 @default.
- W3204406232 cites W2076692471 @default.
- W3204406232 cites W2076714596 @default.
- W3204406232 cites W2079705045 @default.
- W3204406232 cites W2080213202 @default.
- W3204406232 cites W2081413809 @default.
- W3204406232 cites W2083998453 @default.
- W3204406232 cites W2084689743 @default.
- W3204406232 cites W2089924484 @default.
- W3204406232 cites W2091287387 @default.
- W3204406232 cites W2094627951 @default.
- W3204406232 cites W2096908682 @default.
- W3204406232 cites W2097095684 @default.
- W3204406232 cites W2103409993 @default.
- W3204406232 cites W2116328062 @default.
- W3204406232 cites W2118472247 @default.
- W3204406232 cites W2119588378 @default.
- W3204406232 cites W2124432707 @default.
- W3204406232 cites W2134209166 @default.
- W3204406232 cites W2140047003 @default.
- W3204406232 cites W2142304976 @default.