FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204406922> ?p ?o ?g. }

• W3204406922 endingPage "5474" @default.
• W3204406922 startingPage "5467" @default.
• W3204406922 abstract "Background & aimsThe association between higher body mass index (BMI) and cardiometabolic diseases (CMDs, including type 2 diabetes and cardiovascular diseases) is not well understood. We aimed to examine the association of BMI and its long-term changes with cardiometabolic diseases (CMDs) and explore the role of familial background and healthy lifestyle in this association.MethodsWithin the Swedish Twin Registry, 36 622 CMD-free individuals aged ≥40 were followed for up to 16 years. BMI data was collected at baseline and 25–35 years prior to baseline. Healthy lifestyle (non-smoking, no/mild alcohol consumption, and regular physical activity) was assessed as unfavourable (none or only one of these factors) vs. favourable (two or three). Incident CMDs were identified by linkage with the Swedish National Patient Registry. Two strategies were followed: 1) Cox models in all twin individuals; 2) stratified Cox models in CMD-discordant twin pairs.ResultsAt baseline, 16 195 (44.2%) study participants had overweight/obesity (BMI ≥ 25 kg/m2) and 11 202 (30.6%) developed CMDs over follow-up. Among all participants, the hazard ratio (HR) and 95% confidence interval (CI) of developing any CMD was 1.52 (1.45–1.58) for people with overweight/obesity compared to normal BMI (20–25 kg/m2). Compared to stable normal BMI, HRs (95% CIs) of CMDs were 1.28 (1.02–1.59) and 1.33 (1.24–1.43) for only earlier life or only later life overweight/obesity, respectively, and 1.69 (1.55–1.85) for overweight/obesity both in earlier and later life. In stratified Cox analyses conducted among all CMD-discordant twin pairs, overweight/obesity was associated with greater risk of CMDs (1.37, 95% CI 1.18–1.61). In joint effect analysis, the risk of CMDs related to overweight/obesity was diminished 32% among people with a favourable lifestyle (1.51, 95% CI 1.44–1.58) compared to those with overweight/obesity and an unfavourable lifestyle (2.20, 95% CI 2.03–2.38).ConclusionsOverweight/obesity is associated with an increased risk of CMDs, and shared genetic and early-life environmental factors might not account for this association. However, a favourable lifestyle could attenuate the risk of high BMI-related CMDs. The association between higher body mass index (BMI) and cardiometabolic diseases (CMDs, including type 2 diabetes and cardiovascular diseases) is not well understood. We aimed to examine the association of BMI and its long-term changes with cardiometabolic diseases (CMDs) and explore the role of familial background and healthy lifestyle in this association. Within the Swedish Twin Registry, 36 622 CMD-free individuals aged ≥40 were followed for up to 16 years. BMI data was collected at baseline and 25–35 years prior to baseline. Healthy lifestyle (non-smoking, no/mild alcohol consumption, and regular physical activity) was assessed as unfavourable (none or only one of these factors) vs. favourable (two or three). Incident CMDs were identified by linkage with the Swedish National Patient Registry. Two strategies were followed: 1) Cox models in all twin individuals; 2) stratified Cox models in CMD-discordant twin pairs. At baseline, 16 195 (44.2%) study participants had overweight/obesity (BMI ≥ 25 kg/m2) and 11 202 (30.6%) developed CMDs over follow-up. Among all participants, the hazard ratio (HR) and 95% confidence interval (CI) of developing any CMD was 1.52 (1.45–1.58) for people with overweight/obesity compared to normal BMI (20–25 kg/m2). Compared to stable normal BMI, HRs (95% CIs) of CMDs were 1.28 (1.02–1.59) and 1.33 (1.24–1.43) for only earlier life or only later life overweight/obesity, respectively, and 1.69 (1.55–1.85) for overweight/obesity both in earlier and later life. In stratified Cox analyses conducted among all CMD-discordant twin pairs, overweight/obesity was associated with greater risk of CMDs (1.37, 95% CI 1.18–1.61). In joint effect analysis, the risk of CMDs related to overweight/obesity was diminished 32% among people with a favourable lifestyle (1.51, 95% CI 1.44–1.58) compared to those with overweight/obesity and an unfavourable lifestyle (2.20, 95% CI 2.03–2.38). Overweight/obesity is associated with an increased risk of CMDs, and shared genetic and early-life environmental factors might not account for this association. However, a favourable lifestyle could attenuate the risk of high BMI-related CMDs." @default.
• W3204406922 created "2021-10-11" @default.
• W3204406922 creator A5024473114 @default.
• W3204406922 creator A5041863516 @default.
• W3204406922 creator A5060809049 @default.
• W3204406922 creator A5073639694 @default.
• W3204406922 creator A5076233544 @default.
• W3204406922 creator A5077791244 @default.
• W3204406922 creator A5083286397 @default.
• W3204406922 date "2021-11-01" @default.
• W3204406922 modified "2023-10-13" @default.
• W3204406922 title "Association of body mass index and its long-term changes with cardiometabolic diseases: A nationwide twin study" @default.
• W3204406922 cites W1542476404 @default.
• W3204406922 cites W1875304177 @default.
• W3204406922 cites W1932640386 @default.
• W3204406922 cites W1968123605 @default.
• W3204406922 cites W1975499742 @default.
• W3204406922 cites W1988541503 @default.
• W3204406922 cites W1995618284 @default.
• W3204406922 cites W2013532371 @default.
• W3204406922 cites W2017507345 @default.
• W3204406922 cites W2027281604 @default.
• W3204406922 cites W2029346065 @default.
• W3204406922 cites W2039153962 @default.
• W3204406922 cites W2048009183 @default.
• W3204406922 cites W2059024872 @default.
• W3204406922 cites W2077397717 @default.
• W3204406922 cites W2080235308 @default.
• W3204406922 cites W2090073402 @default.
• W3204406922 cites W2093593500 @default.
• W3204406922 cites W2094941678 @default.
• W3204406922 cites W2096391232 @default.
• W3204406922 cites W2101701509 @default.
• W3204406922 cites W2101752541 @default.
• W3204406922 cites W2121477958 @default.
• W3204406922 cites W2127091950 @default.
• W3204406922 cites W2130064617 @default.
• W3204406922 cites W2166194564 @default.
• W3204406922 cites W2251079317 @default.
• W3204406922 cites W2260747663 @default.
• W3204406922 cites W2319176243 @default.
• W3204406922 cites W2517178125 @default.
• W3204406922 cites W2591609485 @default.
• W3204406922 cites W2616807020 @default.
• W3204406922 cites W2755116403 @default.
• W3204406922 cites W2792832138 @default.
• W3204406922 cites W2804186780 @default.
• W3204406922 cites W2854670857 @default.
• W3204406922 cites W2887976033 @default.
• W3204406922 cites W2952819244 @default.
• W3204406922 cites W2965309120 @default.
• W3204406922 cites W2981946841 @default.
• W3204406922 cites W2984149348 @default.
• W3204406922 cites W2999284773 @default.
• W3204406922 cites W3012543744 @default.
• W3204406922 cites W3018087367 @default.
• W3204406922 cites W3021814909 @default.
• W3204406922 cites W3082501133 @default.
• W3204406922 cites W4210527197 @default.
• W3204406922 doi "https://doi.org/10.1016/j.clnu.2021.09.030" @default.
• W3204406922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34656027" @default.
• W3204406922 hasPublicationYear "2021" @default.
• W3204406922 type Work @default.
• W3204406922 sameAs 3204406922 @default.
• W3204406922 citedByCount "2" @default.
• W3204406922 countsByYear W32044069222022 @default.
• W3204406922 crossrefType "journal-article" @default.
• W3204406922 hasAuthorship W3204406922A5024473114 @default.
• W3204406922 hasAuthorship W3204406922A5041863516 @default.
• W3204406922 hasAuthorship W3204406922A5060809049 @default.
• W3204406922 hasAuthorship W3204406922A5073639694 @default.
• W3204406922 hasAuthorship W3204406922A5076233544 @default.
• W3204406922 hasAuthorship W3204406922A5077791244 @default.
• W3204406922 hasAuthorship W3204406922A5083286397 @default.
• W3204406922 hasBestOaLocation W32044069221 @default.
• W3204406922 hasConcept C126322002 @default.
• W3204406922 hasConcept C134018914 @default.
• W3204406922 hasConcept C144024400 @default.
• W3204406922 hasConcept C149923435 @default.
• W3204406922 hasConcept C161890455 @default.
• W3204406922 hasConcept C169594400 @default.
• W3204406922 hasConcept C207103383 @default.
• W3204406922 hasConcept C2777180221 @default.
• W3204406922 hasConcept C2780221984 @default.
• W3204406922 hasConcept C2780586474 @default.
• W3204406922 hasConcept C44249647 @default.
• W3204406922 hasConcept C50382708 @default.
• W3204406922 hasConcept C511355011 @default.
• W3204406922 hasConcept C54355233 @default.
• W3204406922 hasConcept C555293320 @default.
• W3204406922 hasConcept C71924100 @default.
• W3204406922 hasConcept C86803240 @default.
• W3204406922 hasConceptScore W3204406922C126322002 @default.
• W3204406922 hasConceptScore W3204406922C134018914 @default.
• W3204406922 hasConceptScore W3204406922C144024400 @default.
• W3204406922 hasConceptScore W3204406922C149923435 @default.
• W3204406922 hasConceptScore W3204406922C161890455 @default.
• W3204406922 hasConceptScore W3204406922C169594400 @default.

• next