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• W3204407760 endingPage "10803" @default.
• W3204407760 startingPage "10803" @default.
• W3204407760 abstract "Thrombin is the key enzyme of the entire hemostatic process since it is able to exert both procoagulant and anticoagulant functions; therefore, it represents an attractive target for the developments of biomolecules with therapeutic potential. Thrombin can perform its many functional activities because of its ability to recognize a wide variety of substrates, inhibitors, and cofactors. These molecules frequently are bound to positively charged regions on the surface of protein called exosites. In this review, we carried out extensive analyses of the structural determinants of thrombin partnerships by surveying literature data as well as the structural content of the Protein Data Bank (PDB). In particular, we used the information collected on functional, natural, and synthetic molecular ligands to define the anatomy of the exosites and to quantify the interface area between thrombin and exosite ligands. In this framework, we reviewed in detail the specificity of thrombin binding to aptamers, a class of compounds with intriguing pharmaceutical properties. Although these compounds anchor to protein using conservative patterns on its surface, the present analysis highlights some interesting peculiarities. Moreover, the impact of thrombin binding aptamers in the elucidation of the cross-talk between the two distant exosites is illustrated. Collectively, the data and the work here reviewed may provide insights into the design of novel thrombin inhibitors." @default.
• W3204407760 created "2021-10-11" @default.
• W3204407760 creator A5040545960 @default.
• W3204407760 creator A5047004590 @default.
• W3204407760 creator A5068959451 @default.
• W3204407760 creator A5069398146 @default.
• W3204407760 creator A5079313634 @default.
• W3204407760 date "2021-10-06" @default.
• W3204407760 modified "2023-10-16" @default.
• W3204407760 title "Exosite Binding in Thrombin: A Global Structural/Dynamic Overview of Complexes with Aptamers and Other Ligands" @default.
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