FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204433384> ?p ?o ?g. }

• W3204433384 endingPage "128384" @default.
• W3204433384 startingPage "128384" @default.
• W3204433384 abstract "In previous work, we discovered a lead compound and conducted initial SAR studies on a novel series of dioxotriazines to identify the compound as one of the P2X3 receptor antagonists. This compound showed high P2X3 receptor selectivity and a strong analgesic effect. Although not selected for clinical development, the compound was evaluated from various aspects as a tool compound. In the course of the following study, the molecular structures of the dioxotriazines were modified based on pharmacokinetic/pharmacodynamic (PK/PD) analyses. As a result of these SAR studies, Sivopixant (S-600918) was identified as a clinical candidate with potent and selective antagonistic activity (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM) and a strong analgesic effect in the rat partial sciatic nerve ligation model (Seltzer model) of allodynia (ED50, 0.4 mg/kg)." @default.
• W3204433384 created "2021-10-11" @default.
• W3204433384 creator A5010009256 @default.
• W3204433384 creator A5012791544 @default.
• W3204433384 creator A5016679916 @default.
• W3204433384 creator A5017382186 @default.
• W3204433384 creator A5017617224 @default.
• W3204433384 creator A5030947865 @default.
• W3204433384 creator A5035533939 @default.
• W3204433384 creator A5052800819 @default.
• W3204433384 creator A5069450738 @default.
• W3204433384 creator A5072736228 @default.
• W3204433384 creator A5076959343 @default.
• W3204433384 creator A5077787674 @default.
• W3204433384 creator A5079183925 @default.
• W3204433384 creator A5081285964 @default.
• W3204433384 creator A5084791253 @default.
• W3204433384 creator A5085466817 @default.
• W3204433384 creator A5085783912 @default.
• W3204433384 creator A5086791686 @default.
• W3204433384 creator A5088702367 @default.
• W3204433384 date "2021-11-01" @default.
• W3204433384 modified "2023-09-23" @default.
• W3204433384 title "Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists" @default.
• W3204433384 cites W1963993303 @default.
• W3204433384 cites W2092118947 @default.
• W3204433384 cites W2172201406 @default.
• W3204433384 cites W2985550900 @default.
• W3204433384 doi "https://doi.org/10.1016/j.bmcl.2021.128384" @default.
• W3204433384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34587541" @default.
• W3204433384 hasPublicationYear "2021" @default.
• W3204433384 type Work @default.
• W3204433384 sameAs 3204433384 @default.
• W3204433384 citedByCount "11" @default.
• W3204433384 countsByYear W32044333842022 @default.
• W3204433384 countsByYear W32044333842023 @default.
• W3204433384 crossrefType "journal-article" @default.
• W3204433384 hasAuthorship W3204433384A5010009256 @default.
• W3204433384 hasAuthorship W3204433384A5012791544 @default.
• W3204433384 hasAuthorship W3204433384A5016679916 @default.
• W3204433384 hasAuthorship W3204433384A5017382186 @default.
• W3204433384 hasAuthorship W3204433384A5017617224 @default.
• W3204433384 hasAuthorship W3204433384A5030947865 @default.
• W3204433384 hasAuthorship W3204433384A5035533939 @default.
• W3204433384 hasAuthorship W3204433384A5052800819 @default.
• W3204433384 hasAuthorship W3204433384A5069450738 @default.
• W3204433384 hasAuthorship W3204433384A5072736228 @default.
• W3204433384 hasAuthorship W3204433384A5076959343 @default.
• W3204433384 hasAuthorship W3204433384A5077787674 @default.
• W3204433384 hasAuthorship W3204433384A5079183925 @default.
• W3204433384 hasAuthorship W3204433384A5081285964 @default.
• W3204433384 hasAuthorship W3204433384A5084791253 @default.
• W3204433384 hasAuthorship W3204433384A5085466817 @default.
• W3204433384 hasAuthorship W3204433384A5085783912 @default.
• W3204433384 hasAuthorship W3204433384A5086791686 @default.
• W3204433384 hasAuthorship W3204433384A5088702367 @default.
• W3204433384 hasBestOaLocation W32044333841 @default.
• W3204433384 hasConcept C111113717 @default.
• W3204433384 hasConcept C112705442 @default.
• W3204433384 hasConcept C170493617 @default.
• W3204433384 hasConcept C185592680 @default.
• W3204433384 hasConcept C202751555 @default.
• W3204433384 hasConcept C2777752112 @default.
• W3204433384 hasConcept C2777752497 @default.
• W3204433384 hasConcept C2780820201 @default.
• W3204433384 hasConcept C42533223 @default.
• W3204433384 hasConcept C55493867 @default.
• W3204433384 hasConcept C71240020 @default.
• W3204433384 hasConcept C71924100 @default.
• W3204433384 hasConcept C98274493 @default.
• W3204433384 hasConceptScore W3204433384C111113717 @default.
• W3204433384 hasConceptScore W3204433384C112705442 @default.
• W3204433384 hasConceptScore W3204433384C170493617 @default.
• W3204433384 hasConceptScore W3204433384C185592680 @default.
• W3204433384 hasConceptScore W3204433384C202751555 @default.
• W3204433384 hasConceptScore W3204433384C2777752112 @default.
• W3204433384 hasConceptScore W3204433384C2777752497 @default.
• W3204433384 hasConceptScore W3204433384C2780820201 @default.
• W3204433384 hasConceptScore W3204433384C42533223 @default.
• W3204433384 hasConceptScore W3204433384C55493867 @default.
• W3204433384 hasConceptScore W3204433384C71240020 @default.
• W3204433384 hasConceptScore W3204433384C71924100 @default.
• W3204433384 hasConceptScore W3204433384C98274493 @default.
• W3204433384 hasLocation W32044333841 @default.
• W3204433384 hasLocation W32044333842 @default.
• W3204433384 hasOpenAccess W3204433384 @default.
• W3204433384 hasPrimaryLocation W32044333841 @default.
• W3204433384 hasRelatedWork W1758514097 @default.
• W3204433384 hasRelatedWork W1997101420 @default.
• W3204433384 hasRelatedWork W2010116591 @default.
• W3204433384 hasRelatedWork W2042296207 @default.
• W3204433384 hasRelatedWork W2090099591 @default.
• W3204433384 hasRelatedWork W2227061539 @default.
• W3204433384 hasRelatedWork W2594910449 @default.
• W3204433384 hasRelatedWork W2978370557 @default.
• W3204433384 hasRelatedWork W2992709639 @default.
• W3204433384 hasRelatedWork W3163678818 @default.
• W3204433384 hasVolume "52" @default.

• next