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• W3204455872 abstract "Animal models are at the forefront of biomedical research for studies of viral transmission, vaccines, and pathogenesis, yet the need for an ideal large animal model for COVID-19 remains. We used a meta-analysis to evaluate published data relevant to this need. Our literature survey contained 22 studies with data relevant to the incidence of common COVID-19 symptoms in rhesus macaques (Macaca mulatta), cynomolgus macaques (Macaca fascicularis), African green monkeys (Chlorocebus aethiops), and ferrets (Mustela putorius furo). Rhesus macaques had leukocytosis on Day 1 after inoculation and pneumonia on Days 7 and 14 after inoculation, in frequencies that were similar enough to humans to reject the null hypothesis of a Fisher exact test. However, the differences in overall presentation of disease were too different from that of humans to successfully identify any of these 4 species as an ideal large animal of COVID-19. The greatest limitation to the current study is a lack of standardization in experimentation and reporting. To expand our understanding of the pathology of COVID-19 and evalu- ate vaccine immunogenicity, we must extend the unprecedented collaboration that has arisen in the study of COVID-19 to include standardization of animal-based research in an effort to find the optimal animal model." @default.
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• W3204455872 date "2021-10-01" @default.
• W3204455872 modified "2023-09-24" @default.
• W3204455872 title "A Meta-Analysis of Rhesus Macaques (<i>Macaca mulatta</i>), Cynomolgus Macaques (<i>Macaca fascicularis</i>), African green monkeys (<i>Chlorocebus aethiops</i>), and Ferrets (<i>Mustela putorius furo</i>) as Large Animal Models for COVID-19" @default.
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• W3204455872 doi "https://doi.org/10.30802/aalas-cm-21-000032" @default.
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