Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204457315> ?p ?o ?g. }
- W3204457315 abstract "Abstract The neural crest (NC) is an important multipotent embryonic cell population and its impaired specification leads to various developmental defects, often in an anteroposterior (A-P) axial level-specific manner. The mechanisms underlying the correct A-P regionalisation of human NC cells remain elusive. Recent studies have indicated that trunk NC cells, the presumed precursors of the childhood tumour neuroblastoma, are derived from neuromesodermal-potent progenitors of the postcranial body (NMPs). Here we employ human embryonic stem cell differentiation to define how NMP-derived NC cells acquire a posterior axial identity. We show that TBXT, a pro-mesodermal transcription factor, mediates early posterior NC regionalisation together with WNT signalling effectors. This occurs by TBXT-driven chromatin remodelling via its binding in key enhancers within HOX gene clusters and other posterior regulator-associated loci. In contrast, posteriorisation of NMP-derived spinal cord cells is TBXT/WNT-independent and takes place under the influence of FGF signalling. Our work reveals a previously unknown role of TBXT in influencing posterior NC fate and points to the existence of temporally discrete, cell type-dependent modes of posterior axial identity control." @default.
- W3204457315 created "2021-10-11" @default.
- W3204457315 creator A5013685532 @default.
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- W3204457315 creator A5083138771 @default.
- W3204457315 date "2021-09-24" @default.
- W3204457315 modified "2023-10-16" @default.
- W3204457315 title "Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor" @default.
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