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- W3204457942 abstract "Imaging the dynamics of proteins in living cells is a powerful means for understanding cellular functions at a deeper level. Here, we report a versatile method for spatiotemporal imaging of specific endogenous proteins in living mammalian cells. The method employs a bifunctional aptamer capable of selective protein recognition and fluorescent probe-binding, which is induced only when the aptamer specifically binds to its target protein. An aptamer for β-actin protein preferentially recognizes its monomer forms over filamentous forms, resulting in selective G-actin staining in both fixed and living cells. Through actin-drug treatment, the method permitted direct monitoring of the intracellular concentration change of endogenous G-actin. This protein-labeling method, which is highly selective and non-covalent, provides rich insights into the study of spatiotemporal protein dynamics in living cells." @default.
- W3204457942 created "2021-10-11" @default.
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- W3204457942 date "2021-09-28" @default.
- W3204457942 modified "2023-10-17" @default.
- W3204457942 title "RNA-based cooperative protein labeling that permits direct monitoring of the intracellular concentration change of an endogenous protein" @default.
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- W3204457942 doi "https://doi.org/10.1093/nar/gkab839" @default.
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